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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046937
UUCD1 version UUC-HoS-00292
Ensembl Protein ID ENSP00000216127.4
UniProt Accession Q96D21; O95520; Q5THY8; RHES_HUMAN
Genbank Protein ID AAG00868.1; CAG30363.1; AAH13419.1
Protein Name GTP-binding protein Rhes; Ras homolog enriched in striatum; Tumor endothelial marker 2
Genbank Nucleotide ID AF279143; CR456477; AL022334
Gene Name RASD2; TEM2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000100302.6 ENST00000216127.4 ENSP00000216127.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/Other E3 activity/Other 19498170
Organism Homo sapiens
Functional Description
(View)

Functional Description


     GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination.
 GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination.
Protein Sequence
(Fasta)
MMKTLSSGNC TLSVPAKNSY RMVVLGASRV GKSSIVSRFL NGRFEDQYTP TIEDFHRKVY 60
NIRGDMYQLD ILDTSGNHPF PAMRRLSILT GDVFILVFSL DNRESFDEVK RLQKQILEVK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046937|E3,E3 activity/Other|Homo sapiens
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Nucleotide Sequence
(Fasta)
GCGCGGGGAG AAAGAAGCCG TCCCTCCGGC GCTGGGAGAG CTGCAGAGCC GCGGGCAGAG 60
AAGGAGGCCG CGGCCGAGCC CGGCAGCCCG ATACCCCCCA TCCGAGCGAC CCCCTTTGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046937|E3,E3 activity/Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0342--GTP-binding
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0488--Methylation
KW-0547--Nucleotide-binding
KW-0636--Prenylation
KW-1185--Reference proteome
Interpro

IPR027417--P-loop_NTPase
IPR005225--Small_GTP-bd_dom
IPR001806--Small_GTPase
IPR020849--Small_GTPase_Ras
PROSITE

PS51421--RAS
Pfam

PF00071--Ras
Gene Ontology

GO:0005622--C:intracellular
GO:0005886--C:plasma membrane
GO:0031681--F:G-protein beta-subunit binding
GO:0005525--F:GTP binding
GO:0003924--F:GTPase activity
GO:0007626--P:locomotory behavior
GO:0031397--P:negative regulation of protein ubiquitination
GO:0051897--P:positive regulation of protein kinase B signaling
GO:0033235--P:positive regulation of protein sumoylation
GO:0043949--P:regulation of cAMP-mediated signaling
GO:0007264--P:small GTPase mediated signal transduction
GO:0001963--P:synaptic transmission, dopaminergic
KEGG hsa:23551
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002300 Ailuropoda melanoleuca 99.62 1.00e-159 555.00
IUUC-Apl-003857 Anas platyrhynchos 89.85 5.00e-145 506.00
IUUC-Aca-004240 Anolis carolinensis 90.23 3.00e-144 504.00
IUUC-Bta-013228 Bos taurus 98.50 2.00e-157 547.00
IUUC-Cja-018957 Callithrix jacchus 98.87 1.00e-158 551.00
IUUC-Cfa-020131 Canis familiaris 97.74 2.00e-156 544.00
IUUC-Cpo-021614 Cavia porcellus 94.36 1.00e-151 528.00
IUUC-Csa-023844 Chlorocebus sabaeus 100.00 5.00e-160 556.00
IUUC-Dno-029174 Dasypus novemcinctus 98.50 1.00e-157 548.00
IUUC-Dor-031033 Dipodomys ordii 96.62 2.00e-155 541.00
IUUC-Dme-031780 Drosophila melanogaster 48.52 1.00e-63 237.00
IUUC-Ete-032309 Echinops telfairi 97.71 3.00e-101 360.00
IUUC-Eca-034018 Equus caballus 98.87 2.00e-158 551.00
IUUC-Fca-035875 Felis catus 98.12 2.00e-157 548.00
IUUC-Fal-037653 Ficedula albicollis 89.10 2.00e-143 501.00
IUUC-Gga-040943 Gallus gallus 90.23 5.00e-145 506.00
IUUC-Ggo-044688 Gorilla gorilla 100.00 6.00e-160 556.00
IUUC-Itr-048300 Ictidomys tridecemlineatus 97.74 3.00e-156 543.00
IUUC-Lch-050232 Latimeria chalumnae 81.67 8.00e-124 436.00
IUUC-Laf-053676 Loxodonta africana 98.12 9.00e-158 549.00
IUUC-Meu-056249 Macropus eugenii 95.86 2.00e-153 534.00
IUUC-Mga-059257 Meleagris gallopavo 90.23 2.00e-145 507.00
IUUC-Mdo-061991 Monodelphis domestica 95.86 2.00e-153 534.00
IUUC-Mmu-063268 Mus musculus 95.11 4.00e-152 530.00
IUUC-Mpu-066901 Mustela putorius furo 99.25 6.00e-159 552.00
IUUC-Mlu-067258 Myotis lucifugus 98.12 4.00e-157 546.00
IUUC-Nle-068973 Nomascus leucogenys 100.00 6.00e-160 556.00
IUUC-Opr-070743 Ochotona princeps 98.12 3.00e-157 547.00
IUUC-Oan-072868 Ornithorhynchus anatinus 92.88 1.00e-148 518.00
IUUC-Ocu-074790 Oryctolagus cuniculus 97.74 6.00e-157 546.00
IUUC-Oga-088431 Otolemur garnettii 98.50 4.00e-158 550.00
IUUC-Oar-089258 Ovis aries 99.03 5.00e-121 426.00
IUUC-Ptr-090978 Pan troglodytes 100.00 5.00e-160 556.00
IUUC-Pan-092088 Papio anubis 98.32 1.00e-139 488.00
IUUC-Psi-093630 Pelodiscus sinensis 91.35 2.00e-146 511.00
IUUC-Pma-094385 Petromyzon marinus 36.41 4.00e-26 111.00
IUUC-Pab-098310 Pongo abelii 100.00 5.00e-160 556.00
IUUC-Pca-100098 Procavia capensis 95.49 1.00e-150 525.00
IUUC-Pva-102212 Pteropus vampyrus 96.62 8.00e-155 539.00
IUUC-Rno-105257 Rattus norvegicus 95.11 4.00e-152 530.00
IUUC-Sha-106504 Sarcophilus harrisii 96.24 2.00e-154 537.00
IUUC-Sar-113244 Sorex araneus 94.89 1.00e-97 348.00
IUUC-Tgu-116948 Taeniopygia guttata 88.35 1.00e-142 498.00
IUUC-Tbe-127818 Tupaia belangeri 99.62 1.00e-159 555.00
IUUC-Ttr-128286 Tursiops truncatus 98.50 2.00e-157 548.00
Created Date 25-Jun-2017

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