iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089462

Ensembl Protein ID

ENSOARP00000002839.1

UniProt Accession

W5NXE2; W5NXE2_SHEEP

Genbank Protein ID

ENSOARP00000002839

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AMGL01058624

Gene Name

USP49

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000002672.1	ENSOART00000002894.1	ENSOARP00000002839.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.60e-96	323.6	215	599

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp....................................kepkgellksl 53
           tGl+NlgNtCYmNS+LQ+Ls+++++re+ l+  + + ++++                                     ++++ +l+++l
   Q: 215  TGLRNLGNTCYMNSILQVLSHLRKFREAPLSGRPASSSATELssprsdgaeacereglclnggtslsrrleliqnkepSSKHISLCHEL 303
           7******************************4444444333345566777777777778888888888888887777789999****** PP
   S: 54   qklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknksli 142
           ++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ ll+++++el         e+e+++++ l   +++k +k+  +++
   Q: 304  HTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQEL---------ESEGTTRRILIPFSQRKLTKQVLKVV 383
           ******************************************************.........6688888999999************* PP
   S: 143  sdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke..........slqdcLesftkeeelegenkyycekckkkqe..... 216
           +++F+gql sq++c +c+ +s++ epf+dlsl++p++ ++ ++           l+++L++ft++e leg+  y c++c++k++     
   Q: 384  NTIFHGQLLSQVTCVSCNYKSNTIEPFWDLSLEFPERYHCIEKgfvplnqtecLLTEMLAKFTETEALEGRI-YACDQCNSKRRksnpk 471
           **************************************998879*************************965.*******9999999** PP
   S: 217  ......aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke..kkkYeLiavvvHsG.slssGHYv 296
                 a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c+++  ++ +  +  Y+L+avv+H+G +++sGHY+
   Q: 472  plvlseARKQLMIYRLPQVLRLHLKRFRWSGR-NHREKIGVHVVFDQVLTMEPYCCRDMLSSLDkeTFAYDLSAVVMHHGkGFGSGHYT 559
           *****************************997.8889********************876654433999******************** PP
   S: 297  ayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkrr 338
           ay++n++g+ W++++Dsk ++++ eev++   ++aY+lfY++r
   Q: 560  AYCYNTEGGfWVHCNDSKLNVCSVEEVCK---TQAYILFYTQR 599
           *****9999********************...********985 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MDRCKHVGRL RLAQDHSILN PQKWYCRECA TTESVWACLK CSHVACGRYI EDHALKHFEE 60
TRHPLAMEVR DLYVFCYLCK DYVLNDNPEG DLKLLRSSLL AVRGQTQDPP LRRGRTLRAM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATAGAT GCAAACATGT AGGGCGGTTG CGGCTCGCCC AGGACCACTC CATCCTGAAC 60
CCGCAGAAGT GGTACTGCCG GGAGTGCGCC ACCACCGAGT CGGTGTGGGC TTGTCTCAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0035616--P:histone H2B conserved C-terminal lysine deubiquitination
GO:0000398--P:mRNA splicing, via spliceosome
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002395	Ailuropoda melanoleuca	87.60	0.00e+00	1119.00
IUUC-Aca-005278	Anolis carolinensis	70.67	0.00e+00	951.00
IUUC-Bta-012911	Bos taurus	94.52	0.00e+00	824.00
IUUC-Cja-019171	Callithrix jacchus	90.16	0.00e+00	803.00
IUUC-Cfa-020408	Canis familiaris	91.53	0.00e+00	816.00
IUUC-Cpo-022233	Cavia porcellus	87.85	0.00e+00	773.00
IUUC-Cho-025051	Choloepus hoffmanni	90.36	7.00e-179	620.00
IUUC-Dno-029856	Dasypus novemcinctus	89.50	0.00e+00	802.00
IUUC-Fca-035919	Felis catus	96.15	0.00e+00	780.00
IUUC-Gmo-039249	Gadus morhua	77.67	6.00e-146	511.00
IUUC-Gga-040383	Gallus gallus	81.14	0.00e+00	726.00
IUUC-Ggo-044979	Gorilla gorilla	90.16	0.00e+00	806.00
IUUC-Hsa-046743	Homo sapiens	89.93	0.00e+00	803.00
IUUC-Itr-048251	Ictidomys tridecemlineatus	91.10	0.00e+00	818.00
IUUC-Loc-051961	Lepisosteus oculatus	74.46	0.00e+00	630.00
IUUC-Laf-053819	Loxodonta africana	89.51	0.00e+00	793.00
IUUC-Mcc-055048	Macaca mulatta	90.39	0.00e+00	808.00
IUUC-Meu-055971	Macropus eugenii	62.44	6.00e-128	451.00
IUUC-Mga-059720	Meleagris gallopavo	81.09	0.00e+00	725.00
IUUC-Mpu-066318	Mustela putorius furo	91.10	0.00e+00	817.00
IUUC-Mlu-067090	Myotis lucifugus	88.13	0.00e+00	792.00
IUUC-Nle-069486	Nomascus leucogenys	90.39	0.00e+00	808.00
IUUC-Oan-073245	Ornithorhynchus anatinus	89.43	0.00e+00	627.00
IUUC-Ola-086413	Oryzias latipes	57.70	0.00e+00	671.00
IUUC-Oga-088862	Otolemur garnettii	88.79	0.00e+00	793.00
IUUC-Psi-093353	Pelodiscus sinensis	71.67	0.00e+00	966.00
IUUC-Pca-100449	Procavia capensis	87.53	0.00e+00	785.00
IUUC-Pva-102868	Pteropus vampyrus	90.87	0.00e+00	815.00
IUUC-Sar-113561	Sorex araneus	94.61	3.00e-94	338.00
IUUC-Ssc-115735	Sus scrofa	92.69	0.00e+00	830.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence