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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046113
UUCD1 version UUC-HoS-00168
Ensembl Protein ID ENSP00000269383.3
UniProt Accession Q6PJ69; Q4G0F0; Q6DKJ6; Q9BRP6; TRI65_HUMAN
Genbank Protein ID AAH06138.1; AAH21259.2; AAH73831.1; AAH98412.1
Protein Name Tripartite motif-containing protein 65
Genbank Nucleotide ID AC087289; BC021259; BC073831; BC098412
Gene Name TRIM65
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000141569.10 ENST00000591668.5 ENSP00000465034.1
ENSG00000141569.10 ENST00000592642.1 ENSP00000466353.1
ENSG00000141569.10 ENST00000269383.7 ENSP00000269383.3
ENSG00000141569.10 ENST00000543309.5 ENSP00000441480.1
ENSG00000141569.10 ENST00000540128.1 ENSP00000444607.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 19690564
Classification
Family E-value Score Start End
E3 activity/RING/U-box 7.50e-08 34.0 8 56
E3 activity/RING/RING 1.60e-05 27.0 12 51
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/U-box
   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplte 52
           e + C+I l l +dPv+lp+G+ +  ++I+ w +++gk cP +r+p+ +
   Q: 8    EKLTCAICLGLYQDPVTLPCGHNFCGACIRDWWDRCGKACPECREPFPD 56
           5789******************************************954 PP
   

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiCl  ++d p++lpCgH f+  C+  w       ++++ CP Cr
   Q: 12   CAICLGLYQD-PVTLPCGHNFCGACIRDW----WDRCGKA-CPECR 51
           **********.9**************888....5556665.****8 PP
   
Organism Homo sapiens
Protein Sequence
(Fasta)
MAAQLLEEKL TCAICLGLYQ DPVTLPCGHN FCGACIRDWW DRCGKACPEC REPFPDGAEL 60
RRNVALSGVL EVVRAGPARD PGPDPGPGPD PAARCPRHGR PLELFCRTEG RCVCSVCTVR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046113|E3,RING;E3,U-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGCGCGCGAG GCCCGCGGTC CCTTTAAGAC GCCCGGGGCC CGCCTGGCTC TCGCCGCCGC 60
CGGGCCATGG CCGCGCAGCT GCTGGAGGAG AAGCTGACCT GCGCCATCTG CCTGGGGCTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046113|E3,RING;E3,U-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00622--SPRY
PF00643--zf-B_box
PF00097--zf-C3HC4
PRINTS

PR01407--BUTYPHLNCDUF
SMART

SM00336--BBOX
SM00184--RING
SM00449--SPRY
Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0008270--F:zinc ion binding
GO:0010508--P:positive regulation of autophagy
KEGG hsa:201292
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002422 Ailuropoda melanoleuca 75.94 2.00e-150 525.00
IUUC-Atr-002992 Amborella trichopoda 36.76 8.00e-11 61.20
IUUC-Apl-003984 Anas platyrhynchos 43.36 1.00e-17 81.60
IUUC-Ame-011110 Astyanax mexicanus 30.90 3.00e-52 199.00
IUUC-Bta-012830 Bos taurus 75.15 0.00e+00 632.00
IUUC-Bol-016180 Brassica oleracea 38.24 1.00e-11 63.90
IUUC-Bra-017905 Brassica rapa 38.24 1.00e-11 63.90
IUUC-Cja-019398 Callithrix jacchus 90.80 2.00e-128 451.00
IUUC-Cfa-021033 Canis familiaris 75.24 1.00e-149 523.00
IUUC-Cpo-021359 Cavia porcellus 69.83 1.00e-170 592.00
IUUC-Csa-023706 Chlorocebus sabaeus 93.04 0.00e+00 866.00
IUUC-Dre-027965 Danio rerio 30.77 1.00e-55 210.00
IUUC-Dno-029551 Dasypus novemcinctus 57.88 5.00e-153 535.00
IUUC-Dor-030830 Dipodomys ordii 67.06 5.00e-145 507.00
IUUC-Eca-033217 Equus caballus 74.73 1.00e-131 462.00
IUUC-Fca-036403 Felis catus 75.05 0.00e+00 673.00
IUUC-Fal-037118 Ficedula albicollis 41.47 7.00e-91 328.00
IUUC-Gmo-039107 Gadus morhua 31.95 6.00e-54 205.00
IUUC-Gac-042501 Gasterosteus aculeatus 33.40 2.00e-55 209.00
IUUC-Ggo-044481 Gorilla gorilla 89.96 0.00e+00 850.00
IUUC-Itr-049000 Ictidomys tridecemlineatus 66.60 3.00e-161 561.00
IUUC-Lch-050645 Latimeria chalumnae 31.43 1.00e-27 117.00
IUUC-Loc-052279 Lepisosteus oculatus 32.16 2.00e-56 213.00
IUUC-Laf-054143 Loxodonta africana 72.23 5.00e-173 600.00
IUUC-Mcc-055216 Macaca mulatta 91.68 0.00e+00 837.00
IUUC-Meu-056384 Macropus eugenii 65.22 1.00e-72 267.00
IUUC-Mtr-058007 Medicago truncatula 42.65 2.00e-13 70.10
IUUC-Mmr-061758 Microcebus murinus 82.84 0.00e+00 669.00
IUUC-Mdo-062422 Monodelphis domestica 47.49 4.00e-71 261.00
IUUC-Mmu-063753 Mus musculus 64.29 4.00e-162 564.00
IUUC-Mpu-065880 Mustela putorius furo 72.82 2.00e-173 602.00
IUUC-Mlu-067629 Myotis lucifugus 68.94 7.00e-88 317.00
IUUC-Nle-069604 Nomascus leucogenys 93.16 1.00e-171 595.00
IUUC-Opr-070884 Ochotona princeps 65.69 3.00e-169 588.00
IUUC-Oan-073697 Ornithorhynchus anatinus 55.11 2.00e-48 184.00
IUUC-Ocu-073936 Oryctolagus cuniculus 66.92 2.00e-170 592.00
IUUC-Ogu-078203 Oryza glumaepatula 38.24 3.00e-11 62.80
IUUC-Opu-083547 Oryza punctata 38.03 3.00e-11 62.80
IUUC-Oga-087916 Otolemur garnettii 79.44 2.00e-163 568.00
IUUC-Oar-090188 Ovis aries 75.24 1.00e-167 583.00
IUUC-Ptr-091364 Pan troglodytes 98.85 0.00e+00 634.00
IUUC-Pan-092240 Papio anubis 91.30 0.00e+00 885.00
IUUC-Psi-093439 Pelodiscus sinensis 45.89 9.00e-49 186.00
IUUC-Ppa-095897 Physcomitrella patens 46.81 2.00e-09 57.00
IUUC-Pfo-097460 Poecilia formosa 32.04 3.00e-55 209.00
IUUC-Pab-098661 Pongo abelii 88.01 0.00e+00 771.00
IUUC-Pop-099737 Populus trichocarpa 39.71 7.00e-11 63.20
IUUC-Pva-102208 Pteropus vampyrus 75.34 0.00e+00 647.00
IUUC-Rno-105456 Rattus norvegicus 63.53 2.00e-154 539.00
IUUC-Sha-107040 Sarcophilus harrisii 53.36 4.00e-121 428.00
IUUC-Sly-110934 Solanum lycopersicum 43.48 4.00e-14 72.40
IUUC-Sar-113700 Sorex araneus 68.36 4.00e-66 245.00
IUUC-Ssc-115895 Sus scrofa 74.95 0.00e+00 657.00
IUUC-Tru-118244 Takifugu rubripes 29.25 2.00e-48 186.00
IUUC-Tca-121416 Theobroma cacao 41.18 2.00e-13 69.70
IUUC-Tur-126688 Triticum urartu 38.24 6.00e-11 61.60
IUUC-Tbe-127865 Tupaia belangeri 71.17 6.00e-91 327.00
IUUC-Ttr-128578 Tursiops truncatus 76.31 0.00e+00 628.00
IUUC-Vvi-131424 Vitis vinifera 41.18 2.00e-12 67.00
IUUC-Xtr-131897 Xenopus tropicalis 34.71 2.00e-73 269.00
IUUC-Xma-133452 Xiphophorus maculatus 32.16 9.00e-55 207.00
IUUC-Zma-135432 Zea mays 53.19 3.00e-11 63.20
Created Date 25-Jun-2017

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