iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	5.90e-15	55.4	22	79

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlvieke...eqdegWlkgvkelegkrGlfPenFvekl 62
            + +dyea+ d+eLtl++Gd v+v++++   + degW+ g+   +g+ G+fP+n+v+ +
   Q: 22   TAVFDYEAVGDEELTLRRGDRVQVLSQDcavSGDEGWWTGQ-LPSGRVGVFPSNYVAPA 79
           589**********************77622257*******7.99************875 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MEEEEGAAAR EWGATPAGPV WTAVFDYEAV GDEELTLRRG DRVQVLSQDC AVSGDEGWWT 60
GQLPSGRVGV FPSNYVAPAA PAAPTDLQLP QEIPFHELQL EEIIGVGGFG KVYRALWRGE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCTCGGCCT CGGCCTCCGC CGGCGGGCCC CGCTCAACCC GGCCCTCCTT GCGCCCTGAC 60
ATCTTTGGGG ACAGGTGAAC CTATCGCCAG ATCTGCATAG CCAGATCCGA GGGAACGGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome

Interpro

IPR011009--Kinase-like_dom
IPR015785--MAP3K10
IPR016231--MLK1/MLK2/MLK4
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR008271--Ser/Thr_kinase_AS
IPR001452--SH3_domain

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF14604--SH3_9

PRINTS

PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00220--S_TKc
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0004706--F:JUN kinase kinase kinase activity
GO:0003714--F:transcription corepressor activity
GO:0007257--P:activation of JUN kinase activity
GO:0008219--P:cell death
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0018105--P:peptidyl-serine phosphorylation
GO:0018107--P:peptidyl-threonine phosphorylation
GO:0043065--P:positive regulation of apoptotic process
GO:0007224--P:smoothened signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001187	Ailuropoda melanoleuca	93.44	0.00e+00	985.00
IUUC-Atr-002478	Amborella trichopoda	33.33	4.00e-24	106.00
IUUC-Aca-004768	Anolis carolinensis	72.99	0.00e+00	817.00
IUUC-Aly-006459	Arabidopsis lyrata	33.10	5.00e-29	122.00
IUUC-Ath-006581	Arabidopsis thaliana	32.74	2.00e-28	120.00
IUUC-Bta-013545	Bos taurus	97.85	0.00e+00	828.00
IUUC-Bdi-014449	Brachypodium distachyon	32.36	2.00e-25	111.00
IUUC-Bol-016287	Brassica oleracea	32.03	5.00e-28	119.00
IUUC-Bra-016997	Brassica rapa	33.33	4.00e-28	120.00
IUUC-Cja-019696	Callithrix jacchus	86.41	0.00e+00	1234.00
IUUC-Cfa-020789	Canis familiaris	76.95	0.00e+00	1041.00
IUUC-Cpo-021993	Cavia porcellus	91.54	0.00e+00	960.00
IUUC-Csa-024243	Chlorocebus sabaeus	90.33	0.00e+00	1287.00
IUUC-Cho-024961	Choloepus hoffmanni	92.86	2.00e-108	386.00
IUUC-Dre-028573	Danio rerio	72.56	0.00e+00	780.00
IUUC-Dno-029095	Dasypus novemcinctus	87.18	0.00e+00	1184.00
IUUC-Dme-032210	Drosophila melanogaster	49.83	1.00e-141	497.00
IUUC-Fca-036250	Felis catus	96.51	0.00e+00	969.00
IUUC-Gmo-038497	Gadus morhua	72.11	0.00e+00	772.00
IUUC-Gac-042509	Gasterosteus aculeatus	64.81	0.00e+00	758.00
IUUC-Gma-043336	Glycine max	30.74	5.00e-26	113.00
IUUC-Ggo-045471	Gorilla gorilla	86.67	0.00e+00	898.00
IUUC-Hsa-046936	Homo sapiens	91.41	0.00e+00	1308.00
IUUC-Hvu-047798	Hordeum vulgare	32.27	2.00e-24	107.00
IUUC-Itr-048231	Ictidomys tridecemlineatus	97.66	0.00e+00	990.00
IUUC-Loc-052286	Lepisosteus oculatus	68.85	0.00e+00	766.00
IUUC-Mcc-055733	Macaca mulatta	88.50	0.00e+00	1278.00
IUUC-Mtr-058733	Medicago truncatula	32.22	1.00e-26	115.00
IUUC-Mdo-062516	Monodelphis domestica	75.71	0.00e+00	1033.00
IUUC-Mmu-064082	Mus musculus	97.63	0.00e+00	1511.00
IUUC-Mac-065156	Musa acuminata	31.93	6.00e-28	119.00
IUUC-Mpu-065934	Mustela putorius furo	90.71	0.00e+00	1262.00
IUUC-Mlu-068137	Myotis lucifugus	80.79	0.00e+00	1214.00
IUUC-Opr-070869	Ochotona princeps	78.06	0.00e+00	870.00
IUUC-Ont-072492	Oreochromis niloticus	72.65	0.00e+00	790.00
IUUC-Ocu-074350	Oryctolagus cuniculus	89.51	0.00e+00	1189.00
IUUC-Oba-075219	Oryza barthii	35.07	4.00e-24	106.00
IUUC-Obr-076837	Oryza brachyantha	35.07	3.00e-25	110.00
IUUC-Ogl-077159	Oryza glaberrima	34.42	4.00e-24	106.00
IUUC-Ogu-078228	Oryza glumaepatula	34.88	1.00e-24	108.00
IUUC-Oin-079079	Oryza indica	34.50	1.00e-24	108.00
IUUC-Olo-080886	Oryza longistaminata	35.07	4.00e-24	106.00
IUUC-Oni-082188	Oryza nivara	34.94	3.00e-24	107.00
IUUC-Opu-083900	Oryza punctata	35.07	2.00e-24	107.00
IUUC-Oru-084678	Oryza rufipogon	34.50	1.00e-24	108.00
IUUC-Osa-086117	Oryza sativa	34.50	1.00e-24	108.00
IUUC-Oga-088351	Otolemur garnettii	88.97	0.00e+00	1301.00
IUUC-Ptr-091607	Pan troglodytes	91.30	0.00e+00	1307.00
IUUC-Pan-092403	Papio anubis	93.35	0.00e+00	944.00
IUUC-Pab-098396	Pongo abelii	93.87	0.00e+00	981.00
IUUC-Pop-099554	Populus trichocarpa	29.59	3.00e-24	107.00
IUUC-Ppe-101208	Prunus persica	34.09	2.00e-25	111.00
IUUC-Smo-109113	Selaginella moellendorffii	32.72	7.00e-26	111.00
IUUC-Sit-110451	Setaria italica	32.01	2.00e-24	107.00
IUUC-Sly-111849	Solanum lycopersicum	35.09	9.00e-26	112.00
IUUC-Stu-112224	Solanum tuberosum	35.09	1.00e-25	111.00
IUUC-Sbi-113963	Sorghum bicolor	34.58	6.00e-25	109.00
IUUC-Ssc-115332	Sus scrofa	95.19	0.00e+00	985.00
IUUC-Tru-117692	Takifugu rubripes	63.72	0.00e+00	801.00
IUUC-Tsy-119412	Tarsius syrichta	91.91	2.00e-65	243.00
IUUC-Tni-120689	Tetraodon nigroviridis	56.50	0.00e+00	859.00
IUUC-Tca-121461	Theobroma cacao	32.31	9.00e-26	112.00
IUUC-Tae-125555	Triticum aestivum	32.73	1.00e-24	108.00
IUUC-Tur-126322	Triticum urartu	32.26	3.00e-25	110.00
IUUC-Tbe-127643	Tupaia belangeri	97.08	0.00e+00	660.00
IUUC-Ttr-128550	Tursiops truncatus	90.51	0.00e+00	1310.00
IUUC-Vvi-131372	Vitis vinifera	32.26	3.00e-23	103.00
IUUC-Xtr-132108	Xenopus tropicalis	62.92	0.00e+00	971.00
IUUC-Xma-134254	Xiphophorus maculatus	61.34	0.00e+00	815.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence