• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063270
Ensembl Protein ID ENSMUSP00000034467.5
UniProt Accession G3X912; B2RY42; SPRTN_MOUSE
Genbank Protein ID EDL11789.1; AAI58089.1
Protein Name SprT-like domain-containing protein Spartan; Protein with SprT-like domain at the N terminus
Genbank Nucleotide ID AC139158; BC158088
Gene Name Sprtn; Gm505
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000031986.6 ENSMUST00000034467.6 ENSMUSP00000034467.5
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/ZnF/UBZ 5.30e-06 27.7 462 485
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/ZnF/UBZ
   S: 1    llvCPvCqkmvdqtdfeeHlDeCl 24
           l+ CPvCq  v +++++eHlD+Cl
   Q: 462  LVNCPVCQGVVVESQINEHLDRCL 485
           589********************8 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to sites of DNA damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (By similarity).
 Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to sites of DNA damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (By similarity).
Protein Sequence
(Fasta)
MDEDLVVALR LQEEWDVQMA RRAAAAREPV SLVDASWELV DPTPDLQALF LQFNDRFFWG 60
QLEAVEVKWS VRMTLCAGIC TYEGRGGMCS IRLSEPLLKL RPRKDLVETL LHEMIHAYLF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063270|UBD,UBZ|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGGAAGTCAG AGGAGGGTCC GGCACGGACC AGACTTGACG TGTGTCGCCG GACCTCAGCG 60
GCTGTCAGGA GACAACCGGC TGCCTAAAGC CGTCCCCAGC CCGAGCCCAG CGTTCCTAAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063270|UBD,UBZ|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR006640--SprT-like_domain
IPR006642--Znf_Rad18_put
PROSITE

PS00142--ZINC_PROTEASE
Pfam

PF10263--SprT-like
SMART

SM00731--SprT
SM00734--ZnF_Rad18
Gene Ontology

GO:0005694--C:chromosome
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0070530--F:K63-linked polyubiquitin binding
GO:0046872--F:metal ion binding
GO:0031593--F:polyubiquitin binding
GO:0043130--F:ubiquitin binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0031398--P:positive regulation of protein ubiquitination
GO:0009411--P:response to UV
GO:0019985--P:translesion synthesis
KEGG mmu:244666
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001028 Aegilops tauschii 34.33 3.00e-16 79.70
IUUC-Aml-001352 Ailuropoda melanoleuca 69.48 0.00e+00 667.00
IUUC-Atr-002445 Amborella trichopoda 44.44 2.00e-42 166.00
IUUC-Apl-003724 Anas platyrhynchos 41.85 3.00e-67 248.00
IUUC-Aca-005382 Anolis carolinensis 51.81 2.00e-133 468.00
IUUC-Ame-011053 Astyanax mexicanus 48.38 7.00e-103 367.00
IUUC-Bta-012578 Bos taurus 69.08 0.00e+00 655.00
IUUC-Bci-013808 Botrytis cinerea 50.00 1.90e-02 33.50
IUUC-Cel-018317 Caenorhabditis elegans 64.22 4.00e-82 298.00
IUUC-Cja-019824 Callithrix jacchus 70.73 0.00e+00 655.00
IUUC-Cfa-020307 Canis familiaris 72.29 0.00e+00 694.00
IUUC-Cpo-022142 Cavia porcellus 68.29 5.00e-173 600.00
IUUC-Cre-022820 Chlamydomonas reinhardtii 39.07 5.00e-31 128.00
IUUC-Csa-024002 Chlorocebus sabaeus 70.28 0.00e+00 651.00
IUUC-Cho-024371 Choloepus hoffmanni 61.08 3.00e-107 381.00
IUUC-Cin-025503 Ciona intestinalis 60.50 2.00e-89 322.00
IUUC-Csv-025903 Ciona savignyi 72.49 1.00e-89 322.00
IUUC-Cgl-026737 Colletotrichum gloeosporioides 28.21 3.00e-05 43.50
IUUC-Dre-027871 Danio rerio 50.12 1.00e-112 400.00
IUUC-Dno-029800 Dasypus novemcinctus 64.74 4.00e-177 614.00
IUUC-Dor-030856 Dipodomys ordii 57.11 6.00e-125 440.00
IUUC-Dme-031958 Drosophila melanogaster 55.35 2.00e-68 253.00
IUUC-Ete-032321 Echinops telfairi 81.67 1.00e-121 429.00
IUUC-Eca-033610 Equus caballus 69.88 0.00e+00 685.00
IUUC-Eeu-034608 Erinaceus europaeus 58.35 2.00e-153 535.00
IUUC-Fca-035456 Felis catus 69.04 0.00e+00 660.00
IUUC-Fal-036725 Ficedula albicollis 45.16 6.00e-95 341.00
IUUC-Fso-038353 Fusarium solani 34.38 7.00e-05 42.00
IUUC-Gmo-039428 Gadus morhua 61.09 9.00e-92 330.00
IUUC-Ggr-039914 Gaeumannomyces graminis 28.03 2.00e-04 40.40
IUUC-Gga-041138 Gallus gallus 50.43 5.00e-124 437.00
IUUC-Gac-041946 Gasterosteus aculeatus 59.76 9.00e-91 327.00
IUUC-Ggo-044909 Gorilla gorilla 69.56 0.00e+00 649.00
IUUC-Hsa-046804 Homo sapiens 69.76 0.00e+00 648.00
IUUC-Hvu-047629 Hordeum vulgare 29.65 4.00e-17 82.80
IUUC-Itr-048136 Ictidomys tridecemlineatus 70.36 1.00e-173 602.00
IUUC-Lch-050399 Latimeria chalumnae 44.35 2.00e-107 383.00
IUUC-Lpe-050694 Leersia perrieri 33.62 7.00e-19 89.00
IUUC-Loc-052526 Lepisosteus oculatus 55.75 2.00e-105 376.00
IUUC-Lma-053205 Leptosphaeria maculans 43.17 8.00e-49 187.00
IUUC-Laf-054101 Loxodonta africana 70.32 0.00e+00 712.00
IUUC-Mcc-055889 Macaca mulatta 70.48 0.00e+00 653.00
IUUC-Meu-056236 Macropus eugenii 64.00 5.00e-24 105.00
IUUC-Mor-057257 Magnaporthe oryzae 28.48 7.00e-08 51.60
IUUC-Mpo-057531 Magnaporthe poae 28.03 3.00e-04 40.00
IUUC-Mga-059774 Meleagris gallopavo 47.87 2.00e-105 375.00
IUUC-Mmr-061635 Microcebus murinus 67.20 0.00e+00 640.00
IUUC-Mdo-062699 Monodelphis domestica 64.50 1.00e-119 422.00
IUUC-Mac-065121 Musa acuminata 31.47 6.00e-20 91.70
IUUC-Mpu-065833 Mustela putorius furo 70.08 0.00e+00 684.00
IUUC-Mlu-067479 Myotis lucifugus 59.53 5.00e-127 447.00
IUUC-Ncr-068774 Neurospora crassa 30.89 1.00e-05 44.70
IUUC-Nle-069224 Nomascus leucogenys 69.35 0.00e+00 663.00
IUUC-Opr-070699 Ochotona princeps 58.23 6.00e-150 523.00
IUUC-Ont-072423 Oreochromis niloticus 56.39 7.00e-107 381.00
IUUC-Oan-073554 Ornithorhynchus anatinus 66.67 2.00e-34 136.00
IUUC-Ocu-074946 Oryctolagus cuniculus 86.99 7.00e-131 459.00
IUUC-Oba-075090 Oryza barthii 33.97 1.00e-19 91.70
IUUC-Obr-076066 Oryza brachyantha 33.18 3.00e-18 87.40
IUUC-Ogl-077154 Oryza glaberrima 33.97 1.00e-19 91.70
IUUC-Ogu-077955 Oryza glumaepatula 33.97 9.00e-20 92.00
IUUC-Oin-079055 Oryza indica 33.97 1.00e-19 91.30
IUUC-Olo-080733 Oryza longistaminata 41.44 3.00e-15 77.00
IUUC-Ome-081338 Oryza meridionalis 33.97 1.00e-19 91.70
IUUC-Oni-082257 Oryza nivara 33.97 1.00e-19 91.30
IUUC-Opu-083290 Oryza punctata 33.49 5.00e-19 89.70
IUUC-Oru-084633 Oryza rufipogon 33.97 5.00e-19 89.70
IUUC-Osa-086222 Oryza sativa 33.97 1.00e-19 91.70
IUUC-Ola-087333 Oryzias latipes 47.05 9.00e-113 400.00
IUUC-Olu-087722 Ostreococcus lucimarinus 33.77 9.00e-05 43.50
IUUC-Oga-088956 Otolemur garnettii 71.11 0.00e+00 676.00
IUUC-Oar-090014 Ovis aries 69.28 0.00e+00 650.00
IUUC-Ptr-091565 Pan troglodytes 69.76 0.00e+00 648.00
IUUC-Pan-092756 Papio anubis 70.68 0.00e+00 659.00
IUUC-Psi-093051 Pelodiscus sinensis 49.64 4.00e-104 371.00
IUUC-Pma-094409 Petromyzon marinus 71.64 9.00e-58 215.00
IUUC-Pno-094926 Phaeosphaeria nodorum 44.55 1.00e-46 179.00
IUUC-Pfo-096555 Poecilia formosa 53.85 2.00e-102 366.00
IUUC-Pab-098754 Pongo abelii 64.96 2.00e-129 455.00
IUUC-Pca-100166 Procavia capensis 65.21 0.00e+00 652.00
IUUC-Pva-102910 Pteropus vampyrus 61.32 4.00e-165 574.00
IUUC-Pte-104222 Pyrenophora teres 45.15 2.00e-47 182.00
IUUC-Pyt-104688 Pyrenophora triticirepentis 46.77 3.00e-46 179.00
IUUC-Rno-105616 Rattus norvegicus 82.53 0.00e+00 746.00
IUUC-Sha-106669 Sarcophilus harrisii 66.23 6.00e-126 444.00
IUUC-Smo-108867 Selaginella moellendorffii 47.83 3.00e-44 171.00
IUUC-Sit-110221 Setaria italica 26.61 3.00e-16 79.70
IUUC-Sar-113141 Sorex araneus 60.86 4.00e-160 557.00
IUUC-Sbi-114252 Sorghum bicolor 27.64 4.00e-16 79.30
IUUC-Ssc-115883 Sus scrofa 69.29 0.00e+00 665.00
IUUC-Tgu-116997 Taeniopygia guttata 45.71 1.00e-109 390.00
IUUC-Tru-117785 Takifugu rubripes 45.01 9.00e-103 367.00
IUUC-Tsy-119449 Tarsius syrichta 61.68 1.00e-133 469.00
IUUC-Tni-120379 Tetraodon nigroviridis 46.81 4.00e-114 405.00
IUUC-Tre-121886 Trichoderma reesei 41.94 1.00e-04 41.20
IUUC-Tvi-122337 Trichoderma virens 50.00 4.00e-03 36.20
IUUC-Tae-124356 Triticum aestivum 31.88 1.00e-18 88.60
IUUC-Tur-126257 Triticum urartu 29.65 2.00e-19 90.50
IUUC-Tbe-128156 Tupaia belangeri 64.55 1.00e-169 589.00
IUUC-Ttr-128748 Tursiops truncatus 68.30 5.00e-152 530.00
IUUC-Vda-129771 Verticillium dahliae 30.60 3.00e-05 43.50
IUUC-Vpa-130454 Vicugna pacos 61.40 5.00e-75 275.00
IUUC-Xtr-132163 Xenopus tropicalis 44.96 6.00e-111 394.00
IUUC-Xma-134184 Xiphophorus maculatus 51.90 2.00e-106 379.00
IUUC-Zma-134864 Zea mays 28.28 4.00e-17 82.80
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved