iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-070075

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADFV01106501

Gene Name

RFFL

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000001710.2	ENSNLET00000032460.1	ENSNLEP00000024088.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	98.62	0.00e+00	748.00	IUUC-Hsa-045798

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MNKDFIMWAT CCNWFCLDGQ PEEVPPPQGA RMQAYSNPGY SSFPSPTGLE PSCKSCGAHF 60
ANTARKQTCL DCKKNFCMTC SSQLGNGPRL CLLCQRFRAT AFQREELMKM KVKDLRDYLS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTGCACGTG CGCGTGCTCT TCCTCTCTCT CAGTGTGTAT GTATGTATAT GTATGTGTGT 60
ATCTATCATA TATATTTAAA TATATATTCC CCCCTGCTGT CCACGGTGCT TTTTTTCAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001370--BIR_rpt
IPR003034--SAP_dom
IPR011011--Znf_FYVE_PHD
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0010008--C:endosome membrane
GO:0005886--C:plasma membrane
GO:0002947--C:tumor necrosis factor receptor superfamily complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:2001271--P:negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1901797--P:negative regulation of signal transduction by p53 class mediator
GO:0010804--P:negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001630	Ailuropoda melanoleuca	89.16	0.00e+00	640.00
IUUC-Apl-004124	Anas platyrhynchos	66.30	9.00e-126	442.00
IUUC-Aly-005548	Arabidopsis lyrata	47.06	1.00e-08	55.50
IUUC-Ame-011616	Astyanax mexicanus	59.67	2.00e-105	375.00
IUUC-Bta-012374	Bos taurus	84.97	0.00e+00	634.00
IUUC-Cja-019780	Callithrix jacchus	95.05	0.00e+00	686.00
IUUC-Cfa-021252	Canis familiaris	91.80	0.00e+00	650.00
IUUC-Cpo-022047	Cavia porcellus	90.16	0.00e+00	660.00
IUUC-Csa-023161	Chlorocebus sabaeus	98.07	0.00e+00	741.00
IUUC-Cho-024316	Choloepus hoffmanni	90.10	5.00e-155	540.00
IUUC-Cne-026858	Cryptococcus neoformans	25.15	6.00e-07	48.50
IUUC-Dre-028596	Danio rerio	55.22	1.00e-109	389.00
IUUC-Dno-029333	Dasypus novemcinctus	91.46	0.00e+00	662.00
IUUC-Ete-033163	Echinops telfairi	83.20	7.00e-166	576.00
IUUC-Eca-033994	Equus caballus	91.80	0.00e+00	682.00
IUUC-Eeu-035162	Erinaceus europaeus	86.00	4.00e-130	456.00
IUUC-Fca-036418	Felis catus	90.98	0.00e+00	701.00
IUUC-Fal-037427	Ficedula albicollis	65.67	9.00e-134	469.00
IUUC-Gga-041053	Gallus gallus	67.77	4.00e-132	464.00
IUUC-Ggo-045436	Gorilla gorilla	98.62	0.00e+00	748.00
IUUC-Hsa-045798	Homo sapiens	98.62	0.00e+00	748.00
IUUC-Itr-048077	Ictidomys tridecemlineatus	91.53	0.00e+00	654.00
IUUC-Lch-050639	Latimeria chalumnae	62.81	9.00e-127	446.00
IUUC-Laf-053355	Loxodonta africana	88.89	0.00e+00	632.00
IUUC-Mcc-055222	Macaca mulatta	97.52	0.00e+00	684.00
IUUC-Meu-056692	Macropus eugenii	77.41	6.00e-159	553.00
IUUC-Mga-059298	Meleagris gallopavo	66.58	8.00e-132	463.00
IUUC-Mmr-061792	Microcebus murinus	90.08	0.00e+00	642.00
IUUC-Mdo-062986	Monodelphis domestica	80.27	1.00e-169	588.00
IUUC-Mmu-063356	Mus musculus	89.07	0.00e+00	654.00
IUUC-Mpu-066273	Mustela putorius furo	91.53	0.00e+00	703.00
IUUC-Mlu-066953	Myotis lucifugus	90.71	0.00e+00	684.00
IUUC-Opr-070838	Ochotona princeps	88.98	0.00e+00	639.00
IUUC-Ont-071967	Oreochromis niloticus	51.24	2.00e-91	329.00
IUUC-Ocu-074807	Oryctolagus cuniculus	90.44	0.00e+00	686.00
IUUC-Obr-076159	Oryza brachyantha	41.07	3.00e-08	50.80
IUUC-Ola-086903	Oryzias latipes	68.21	8.00e-56	210.00
IUUC-Oga-088536	Otolemur garnettii	90.63	0.00e+00	627.00
IUUC-Oar-089838	Ovis aries	85.52	4.00e-179	620.00
IUUC-Ptr-090962	Pan troglodytes	98.35	0.00e+00	747.00
IUUC-Pan-092853	Papio anubis	97.52	0.00e+00	736.00
IUUC-Psi-093164	Pelodiscus sinensis	65.75	5.00e-128	450.00
IUUC-Pma-094104	Petromyzon marinus	45.51	3.00e-57	215.00
IUUC-Pno-094968	Phaeosphaeria nodorum	36.73	1.00e-08	56.20
IUUC-Pab-098304	Pongo abelii	98.92	0.00e+00	759.00
IUUC-Pca-100316	Procavia capensis	88.98	7.00e-178	616.00
IUUC-Ppe-101490	Prunus persica	37.80	1.00e-09	57.80
IUUC-Pva-102612	Pteropus vampyrus	77.13	2.00e-157	548.00
IUUC-Pte-104027	Pyrenophora teres	34.69	1.00e-07	52.80
IUUC-Rno-105449	Rattus norvegicus	89.81	0.00e+00	646.00
IUUC-Sha-107578	Sarcophilus harrisii	79.45	9.00e-158	549.00
IUUC-Sit-110649	Setaria italica	41.51	3.00e-08	50.80
IUUC-Sar-113638	Sorex araneus	85.67	1.00e-175	608.00
IUUC-Ssc-116401	Sus scrofa	88.86	0.00e+00	686.00
IUUC-Tru-118765	Takifugu rubripes	49.86	2.00e-83	301.00
IUUC-Tsy-118850	Tarsius syrichta	89.44	2.00e-153	534.00
IUUC-Tbe-128086	Tupaia belangeri	84.30	2.00e-180	624.00
IUUC-Ttr-128249	Tursiops truncatus	68.32	2.00e-137	481.00
IUUC-Vpa-130816	Vicugna pacos	87.21	4.00e-41	161.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence