iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004492

UUCD1 version

UUC-AnC-00014

Ensembl Protein ID

ENSACAP00000014684.3

UniProt Accession

H9GLQ0; H9GLQ0_ANOCA

Protein Name

Uncharacterized protein

Gene Name

vhl

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000014956.3	ENSACAT00000014982.3	ENSACAP00000014684.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	27.88	9.00e-04	40.00	IUUC-Dme-031988
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	78.74	7.00e-56	213.00	IUUC-Hsa-046547

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MPQRPGEEEE EERRLRSLNS REPCQVIFCN RTPRVVSPVW LDFEGVPRPY PSLKPGTGRR 60
MHSYLKHLWL FRDAGTDDSL LVNQAELFVA SHNTNGQPIF ANITLPVFTL KERCLQVVRT 120

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Nucleotide Sequence
(Fasta)

CCCAAGTTTG CCCATGCCTG GTGTAGATGC ATTCTTGATT GTTCCCACTG ACCAATCCAA 60
CCATCTTGTG AGTGAATGAA AACTCCTCTT TAGCGCAGAG CTCTAACTGC GCAGGCGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR002714--VHL
IPR024048--VHL_alpha_dom
IPR024053--VHL_beta_dom
IPR022772--VHL_tumour_suppress_b/a_dom

Pfam

PF01847--VHL
PF17211--VHL_C

Gene Ontology

GO:0005929--C:cilium
GO:0031462--C:Cul2-RING ubiquitin ligase complex
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0030891--C:VCB complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0001525--P:angiogenesis
GO:0043534--P:blood vessel endothelial cell migration
GO:0061073--P:ciliary body morphogenesis
GO:0030198--P:extracellular matrix organization
GO:0048069--P:eye pigmentation
GO:0048877--P:homeostasis of number of retina cells
GO:0061072--P:iris morphogenesis
GO:0006582--P:melanin metabolic process
GO:0045602--P:negative regulation of endothelial cell differentiation
GO:0010629--P:negative regulation of gene expression
GO:1902072--P:negative regulation of hypoxia-inducible factor-1alpha signaling pathway
GO:0070244--P:negative regulation of thymocyte apoptotic process
GO:0006607--P:NLS-bearing protein import into nucleus
GO:0003310--P:pancreatic A cell differentiation
GO:0050679--P:positive regulation of epithelial cell proliferation
GO:0010498--P:proteasomal protein catabolic process
GO:0016567--P:protein ubiquitination
GO:2001233--P:regulation of apoptotic signaling pathway
GO:1903827--P:regulation of cellular protein localization
GO:0003309--P:type B pancreatic cell differentiation

KEGG

acs:100560920

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002327	Ailuropoda melanoleuca	70.80	4.00e-49	187.00
IUUC-Apl-003580	Anas platyrhynchos	79.71	5.00e-26	108.00
IUUC-Ang-009806	Aspergillus niger	52.94	8.20e-02	27.70
IUUC-Ame-011818	Astyanax mexicanus	50.34	5.00e-39	153.00
IUUC-Bta-013459	Bos taurus	79.26	3.00e-61	227.00
IUUC-Cel-018173	Caenorhabditis elegans	27.47	3.30e-02	30.80
IUUC-Cja-019826	Callithrix jacchus	78.52	1.00e-59	222.00
IUUC-Cfa-021280	Canis familiaris	77.78	2.00e-58	218.00
IUUC-Cpo-022544	Cavia porcellus	74.19	4.00e-61	226.00
IUUC-Cre-022809	Chlamydomonas reinhardtii	35.19	2.00e-05	43.10
IUUC-Csa-023644	Chlorocebus sabaeus	78.52	3.00e-60	224.00
IUUC-Cho-024479	Choloepus hoffmanni	48.28	4.00e-25	106.00
IUUC-Cin-025505	Ciona intestinalis	27.12	8.00e-06	42.70
IUUC-Cme-027232	Cyanidioschyzon merolae	31.43	2.00e-05	42.40
IUUC-Dre-028350	Danio rerio	48.99	4.00e-28	117.00
IUUC-Dno-029207	Dasypus novemcinctus	74.47	8.00e-36	142.00
IUUC-Dor-030912	Dipodomys ordii	52.59	3.00e-34	137.00
IUUC-Dme-031988	Drosophila melanogaster	27.88	7.00e-05	40.00
IUUC-Eca-034007	Equus caballus	82.50	3.00e-14	69.30
IUUC-Fca-036350	Felis catus	77.37	8.00e-58	216.00
IUUC-Fal-037192	Ficedula albicollis	70.37	5.00e-50	189.00
IUUC-Gmo-038921	Gadus morhua	57.04	3.00e-41	160.00
IUUC-Gga-041016	Gallus gallus	70.37	1.00e-50	191.00
IUUC-Gac-042560	Gasterosteus aculeatus	48.89	6.00e-33	133.00
IUUC-Ggo-045419	Gorilla gorilla	79.26	2.00e-60	224.00
IUUC-Hsa-046547	Homo sapiens	79.26	2.00e-60	224.00
IUUC-Itr-048225	Ictidomys tridecemlineatus	79.26	1.00e-60	224.00
IUUC-Lch-050463	Latimeria chalumnae	63.45	8.00e-50	189.00
IUUC-Loc-052053	Lepisosteus oculatus	58.52	1.00e-44	171.00
IUUC-Laf-053893	Loxodonta africana	77.78	3.00e-59	220.00
IUUC-Mcc-055347	Macaca mulatta	62.99	2.00e-39	155.00
IUUC-Mdo-062169	Monodelphis domestica	72.04	1.00e-34	137.00
IUUC-Mmu-064366	Mus musculus	77.78	8.00e-59	219.00
IUUC-Mpu-066593	Mustela putorius furo	78.52	1.00e-59	221.00
IUUC-Mlu-066926	Myotis lucifugus	80.00	5.00e-61	226.00
IUUC-Nle-069724	Nomascus leucogenys	79.26	2.00e-60	224.00
IUUC-Opr-070679	Ochotona princeps	75.56	3.00e-58	217.00
IUUC-Ont-071332	Oreochromis niloticus	51.11	1.00e-37	148.00
IUUC-Ola-086869	Oryzias latipes	55.56	2.00e-39	154.00
IUUC-Oga-089124	Otolemur garnettii	77.37	7.00e-59	219.00
IUUC-Oar-089799	Ovis aries	81.93	2.00e-36	143.00
IUUC-Ptr-091186	Pan troglodytes	81.93	5.00e-36	142.00
IUUC-Pan-092150	Papio anubis	77.78	2.00e-59	221.00
IUUC-Psi-094039	Pelodiscus sinensis	69.92	2.00e-50	191.00
IUUC-Pma-094129	Petromyzon marinus	44.44	1.00e-24	105.00
IUUC-Pfo-096892	Poecilia formosa	51.11	2.00e-34	137.00
IUUC-Pab-097822	Pongo abelii	79.26	2.00e-60	224.00
IUUC-Pca-101058	Procavia capensis	77.04	1.00e-55	209.00
IUUC-Pva-102932	Pteropus vampyrus	79.26	3.00e-60	224.00
IUUC-Rno-105050	Rattus norvegicus	78.52	1.00e-60	225.00
IUUC-Sha-106738	Sarcophilus harrisii	81.93	2.00e-35	139.00
IUUC-Ssc-115973	Sus scrofa	77.78	3.00e-60	224.00
IUUC-Tgu-116663	Taeniopygia guttata	77.11	1.00e-31	127.00
IUUC-Tru-118654	Takifugu rubripes	57.78	8.00e-41	159.00
IUUC-Ttr-128418	Tursiops truncatus	78.52	2.00e-60	224.00
IUUC-Vpa-130268	Vicugna pacos	72.83	8.00e-35	139.00
IUUC-Xtr-132506	Xenopus tropicalis	60.53	4.00e-51	193.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence