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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046905
UUCD1 version UUC-HoS-00247
Ensembl Protein ID ENSP00000428698.2
UniProt Accession Q8TC41; H7C5V4; Q5TCA4; Q9BX48; RN217_HUMAN
Genbank Protein ID CAC36346.1; CAI22999.1; AAH26087.1
Protein Name Probable E3 ubiquitin-protein ligase RNF217; IBR domain-containing protein 1; RING finger protein 217
Genbank Nucleotide ID AL136128; AL136128; AL355296
Gene Name RNF217; C6orf172; IBRDC1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000146373.16 ENST00000521654.6 ENSP00000428698.2
ENSG00000146373.16 ENST00000519565.5 ENSP00000429012.1
ENSG00000146373.16 ENST00000359704.2 ENSP00000352734.2
ENSG00000146373.16 ENST00000432158.6 ENSP00000404282.2
ENSG00000146373.16 ENST00000560949.5 ENSP00000452812.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
MenthaInWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 20682791
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
 E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Protein Sequence
(Fasta)
MGEEQSTVSG GGGPQESQTL ASGTAGHPEP PRPQGDSARA PPLRAASAEP SGGGCGSDWG 60
CADTSAPEPA RSLGPPGWSK SRAPAQPAGL ALTGPLNPQT LPLQLELEEE EEEAGDRKEG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046905|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGGCGAGG AGCAGAGCAC GGTGAGCGGC GGCGGCGGGC CCCAGGAGTC GCAGACCCTG 60
GCCAGTGGCA CTGCGGGCCA CCCTGAGCCC CCGAGGCCTC AGGGGGACAG CGCCCGGGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046905|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001370--BIR_rpt
IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
Pfam

PF01485--IBR
SMART

SM00647--IBR
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016021--C:integral component of membrane
GO:0000151--C:ubiquitin ligase complex
GO:0046872--F:metal ion binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG hsa:154214
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000190 Aegilops tauschii 26.64 6.00e-19 88.20
IUUC-Aml-001424 Ailuropoda melanoleuca 97.61 6.00e-125 439.00
IUUC-Atr-002709 Amborella trichopoda 29.33 7.00e-18 86.30
IUUC-Apl-004119 Anas platyrhynchos 90.76 3.00e-127 447.00
IUUC-Aca-004331 Anolis carolinensis 79.64 9.00e-115 406.00
IUUC-Aly-006445 Arabidopsis lyrata 26.73 5.00e-16 79.30
IUUC-Ame-011391 Astyanax mexicanus 55.84 2.00e-121 429.00
IUUC-Bta-013031 Bos taurus 98.00 2.00e-138 484.00
IUUC-Bci-013593 Botrytis cinerea 26.56 1.00e-17 84.70
IUUC-Bol-016072 Brassica oleracea 26.14 5.00e-15 76.30
IUUC-Bra-018037 Brassica rapa 26.98 1.00e-14 75.10
IUUC-Cja-019367 Callithrix jacchus 99.02 0.00e+00 642.00
IUUC-Cfa-020360 Canis familiaris 96.55 3.00e-143 501.00
IUUC-Cpo-022283 Cavia porcellus 97.60 3.00e-123 434.00
IUUC-Csa-023174 Chlorocebus sabaeus 99.67 0.00e+00 643.00
IUUC-Dre-028219 Danio rerio 54.01 3.00e-113 402.00
IUUC-Dno-029150 Dasypus novemcinctus 99.18 1.00e-147 515.00
IUUC-Eca-034129 Equus caballus 98.59 1.00e-159 555.00
IUUC-Fca-036093 Felis catus 97.60 9.00e-138 482.00
IUUC-Fal-037155 Ficedula albicollis 80.65 1.00e-147 516.00
IUUC-Gmo-039328 Gadus morhua 64.49 7.00e-102 363.00
IUUC-Gga-041198 Gallus gallus 73.23 7.00e-148 516.00
IUUC-Gac-041506 Gasterosteus aculeatus 66.91 1.00e-104 372.00
IUUC-Itr-048769 Ictidomys tridecemlineatus 98.24 2.00e-90 323.00
IUUC-Lch-049864 Latimeria chalumnae 92.90 2.00e-82 297.00
IUUC-Loc-052491 Lepisosteus oculatus 67.19 1.00e-123 436.00
IUUC-Laf-054434 Loxodonta africana 96.31 3.00e-133 467.00
IUUC-Mcc-054775 Macaca mulatta 98.71 0.00e+00 959.00
IUUC-Mtr-058155 Medicago truncatula 26.47 1.00e-17 84.30
IUUC-Mga-059829 Meleagris gallopavo 89.92 3.00e-124 437.00
IUUC-Mmr-061731 Microcebus murinus 90.59 0.00e+00 827.00
IUUC-Mdo-062999 Monodelphis domestica 66.85 3.00e-167 581.00
IUUC-Mmu-063659 Mus musculus 76.29 0.00e+00 669.00
IUUC-Mpu-066110 Mustela putorius furo 97.51 2.00e-156 544.00
IUUC-Mlu-067706 Myotis lucifugus 98.39 2.00e-138 484.00
IUUC-Nle-069289 Nomascus leucogenys 99.35 0.00e+00 642.00
IUUC-Opr-070800 Ochotona princeps 99.52 4.00e-126 443.00
IUUC-Ont-072164 Oreochromis niloticus 71.38 1.00e-110 392.00
IUUC-Oan-073332 Ornithorhynchus anatinus 94.15 6.00e-87 312.00
IUUC-Ocu-074266 Oryctolagus cuniculus 98.59 2.00e-159 555.00
IUUC-Ogu-078368 Oryza glumaepatula 24.88 3.00e-13 70.10
IUUC-Opu-083215 Oryza punctata 26.47 3.00e-19 89.70
IUUC-Ola-087213 Oryzias latipes 67.62 4.00e-107 380.00
IUUC-Oga-088033 Otolemur garnettii 98.70 8.00e-173 599.00
IUUC-Oar-089295 Ovis aries 92.64 0.00e+00 705.00
IUUC-Pan-091768 Papio anubis 99.67 0.00e+00 643.00
IUUC-Psi-093567 Pelodiscus sinensis 75.92 5.00e-152 530.00
IUUC-Ppa-095998 Physcomitrella patens 31.13 3.00e-19 90.10
IUUC-Pfo-096655 Poecilia formosa 52.00 7.00e-117 414.00
IUUC-Pop-099816 Populus trichocarpa 29.41 1.00e-18 87.40
IUUC-Ppe-101728 Prunus persica 27.23 4.00e-17 82.80
IUUC-Pyt-104493 Pyrenophora triticirepentis 30.57 8.00e-18 84.70
IUUC-Rno-105176 Rattus norvegicus 91.50 0.00e+00 643.00
IUUC-Sly-111393 Solanum lycopersicum 29.38 4.00e-19 89.70
IUUC-Stu-112779 Solanum tuberosum 30.69 4.00e-20 92.00
IUUC-Sar-113564 Sorex araneus 99.04 6.00e-126 442.00
IUUC-Sbi-114532 Sorghum bicolor 27.23 2.00e-17 83.20
IUUC-Ssc-115296 Sus scrofa 98.39 2.00e-138 484.00
IUUC-Tgu-117362 Taeniopygia guttata 90.64 1.00e-113 402.00
IUUC-Tru-118499 Takifugu rubripes 67.51 4.00e-106 377.00
IUUC-Tni-119677 Tetraodon nigroviridis 67.03 3.00e-103 367.00
IUUC-Tca-121059 Theobroma cacao 27.91 9.00e-18 84.00
IUUC-Tur-126368 Triticum urartu 27.51 9.00e-18 84.30
IUUC-Vvi-130951 Vitis vinifera 25.85 2.00e-15 76.30
IUUC-Xtr-132796 Xenopus tropicalis 76.19 2.00e-133 469.00
Created Date 25-Jun-2017

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