iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Itr-048887

Ensembl Protein ID

ENSSTOP00000000828.2

UniProt Accession

I3LXL5; I3LXL5_ICTTR

Genbank Protein ID

ENSSTOP00000000828

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTP01104452

Gene Name

NCK2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000000925.2	ENSSTOT00000000924.2	ENSSTOP00000000828.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.00e-43	145.6	197	256

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +++vq+ly++++++++eL++ kG++++viek e+d +W+k+ k+++g+ Gl+P+n+v+ l+
   Q: 197  LHVVQTLYPFSSVTEEELNFDKGETMEVIEKPENDPEWWKC-KNARGQVGLVPKNYVVVLN 256
           689**************************************.7**************9987 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

MTEEVIVIAK WDYTAQQDQE LDIKKNERLW LLDDSKTWWR VRNAANRTGY VPSNYVERKN 60
SLKKGSLVKN LKDTLGLGKT RRKPSARDAS PTPSTDAEYP SNGSGADRIY DLNIPAFVKF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTTCCATAT CCTGGAGAAA ACTGGTGGCA GAGCTGTAAT AAGAGCTGTC ATGGCCTGAT 60
TTTTCAAGTT GGTCAAAGGA TGATTTTTCA AGTCGGGTGG TCCTCTAATG AGTTTCTCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR017304--NCK
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF14604--SH3_9

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0012506--C:vesicle membrane
GO:0007015--P:actin filament organization
GO:0016477--P:cell migration
GO:0048013--P:ephrin receptor signaling pathway
GO:0030032--P:lamellipodium assembly
GO:1903912--P:negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0033137--P:negative regulation of peptidyl-serine phosphorylation
GO:1903898--P:negative regulation of PERK-mediated unfolded protein response
GO:1990441--P:negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0030838--P:positive regulation of actin filament polymerization
GO:1902237--P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0036493--P:positive regulation of translation in response to endoplasmic reticulum stress

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001404	Ailuropoda melanoleuca	95.79	0.00e+00	721.00
IUUC-Apl-003456	Anas platyrhynchos	91.05	0.00e+00	698.00
IUUC-Aca-005105	Anolis carolinensis	90.53	0.00e+00	696.00
IUUC-Ame-010966	Astyanax mexicanus	78.33	2.00e-173	601.00
IUUC-Bta-012424	Bos taurus	87.63	0.00e+00	626.00
IUUC-Cja-019898	Callithrix jacchus	96.58	0.00e+00	726.00
IUUC-Cfa-020830	Canis familiaris	95.26	0.00e+00	717.00
IUUC-Cpo-021487	Cavia porcellus	88.16	0.00e+00	645.00
IUUC-Csa-023693	Chlorocebus sabaeus	96.58	0.00e+00	725.00
IUUC-Cin-025348	Ciona intestinalis	37.06	9.00e-66	243.00
IUUC-Dre-028334	Danio rerio	80.68	1.00e-174	605.00
IUUC-Dno-028973	Dasypus novemcinctus	92.89	0.00e+00	707.00
IUUC-Dor-031003	Dipodomys ordii	95.26	0.00e+00	702.00
IUUC-Ete-032792	Echinops telfairi	84.11	0.00e+00	632.00
IUUC-Eca-033656	Equus caballus	95.79	0.00e+00	722.00
IUUC-Fca-036347	Felis catus	95.79	0.00e+00	721.00
IUUC-Fal-037095	Ficedula albicollis	90.79	0.00e+00	699.00
IUUC-Gmo-039410	Gadus morhua	70.92	2.00e-157	548.00
IUUC-Gga-040155	Gallus gallus	91.05	0.00e+00	699.00
IUUC-Gac-041787	Gasterosteus aculeatus	72.84	3.00e-163	567.00
IUUC-Ggo-044805	Gorilla gorilla	96.84	0.00e+00	727.00
IUUC-Hsa-046585	Homo sapiens	96.84	0.00e+00	727.00
IUUC-Lch-049795	Latimeria chalumnae	86.84	0.00e+00	666.00
IUUC-Loc-051985	Lepisosteus oculatus	86.58	0.00e+00	644.00
IUUC-Laf-054228	Loxodonta africana	93.16	0.00e+00	707.00
IUUC-Mcc-055402	Macaca mulatta	96.58	0.00e+00	725.00
IUUC-Mga-059374	Meleagris gallopavo	91.05	0.00e+00	699.00
IUUC-Mmr-061453	Microcebus murinus	96.58	0.00e+00	726.00
IUUC-Mdo-063080	Monodelphis domestica	90.26	0.00e+00	695.00
IUUC-Mmu-063529	Mus musculus	95.53	0.00e+00	717.00
IUUC-Mpu-066815	Mustela putorius furo	95.79	0.00e+00	721.00
IUUC-Mlu-067132	Myotis lucifugus	91.80	2.00e-155	540.00
IUUC-Nle-069371	Nomascus leucogenys	96.84	0.00e+00	727.00
IUUC-Opr-070948	Ochotona princeps	96.55	0.00e+00	700.00
IUUC-Ont-071410	Oreochromis niloticus	74.56	3.00e-158	550.00
IUUC-Oan-073304	Ornithorhynchus anatinus	89.54	4.00e-157	546.00
IUUC-Ocu-074783	Oryctolagus cuniculus	97.37	0.00e+00	724.00
IUUC-Ola-086808	Oryzias latipes	73.01	5.00e-157	546.00
IUUC-Oga-088391	Otolemur garnettii	97.11	0.00e+00	722.00
IUUC-Oar-090025	Ovis aries	81.58	1.00e-167	582.00
IUUC-Ptr-090975	Pan troglodytes	96.84	0.00e+00	727.00
IUUC-Pan-092287	Papio anubis	96.58	0.00e+00	725.00
IUUC-Psi-093413	Pelodiscus sinensis	91.32	0.00e+00	700.00
IUUC-Pfo-097129	Poecilia formosa	75.70	2.00e-163	568.00
IUUC-Pab-098756	Pongo abelii	96.84	0.00e+00	727.00
IUUC-Pca-100235	Procavia capensis	80.00	3.00e-178	617.00
IUUC-Pva-102294	Pteropus vampyrus	92.37	0.00e+00	686.00
IUUC-Rno-105090	Rattus norvegicus	95.53	0.00e+00	717.00
IUUC-Sha-107521	Sarcophilus harrisii	90.79	0.00e+00	698.00
IUUC-Sar-113697	Sorex araneus	89.06	0.00e+00	662.00
IUUC-Ssc-115958	Sus scrofa	86.71	1.00e-159	555.00
IUUC-Tgu-116559	Taeniopygia guttata	89.21	0.00e+00	675.00
IUUC-Tru-117677	Takifugu rubripes	75.44	4.00e-163	566.00
IUUC-Tni-120434	Tetraodon nigroviridis	75.51	2.00e-162	565.00
IUUC-Tbe-127931	Tupaia belangeri	94.30	3.00e-174	603.00
IUUC-Ttr-128993	Tursiops truncatus	87.37	0.00e+00	642.00
IUUC-Xtr-132543	Xenopus tropicalis	83.46	0.00e+00	650.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence