iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	1.60e-15	58.8	30	92

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikd.vqpevfrallkFlYtgklde 67
           +Dv +vv+g+ f+ah++vLaasS +F++lf+++     sk+  e+ + v p +f+++l+F+Ytg+l++
   Q: 30   CDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGN-----SKSAFELPGsVPPACFQQILSFCYTGRLTM 92
           8*****************************774.....46778***88*****************987 PP

Organism

Homo sapiens

Functional Description
(View)

Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53.

Protein Sequence
(Fasta)

MSQMLHIEIP NFGNTVLGCL NEQRLLGLYC DVSIVVKGQA FKAHRAVLAA SSLYFRDLFS 60
GNSKSAFELP GSVPPACFQQ ILSFCYTGRL TMTASEQLVV MYTAGFLQIQ HIVERGTDLM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAGTCCATG GGAGCCGGAG CGCCGGGACG CCAAGCACTT CCTGCCGCGG GCGGCGCGCC 60
GCAGCTGCCC AGGCCGGACC GGGCCGGGCG CCCGCAGGTA CCGCCAACTT GGCGCGCGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation

Interpro

IPR018379--BEN_domain
IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ

PROSITE

PS51457--BEN
PS50097--BTB

Pfam

PF10523--BEN
PF00651--BTB

SMART

SM01025--BEN
SM00225--BTB

Gene Ontology

GO:0005739--C:mitochondrion
GO:0016604--C:nuclear body
GO:0000790--C:nuclear chromatin
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0004407--F:histone deacetylase activity
GO:0042826--F:histone deacetylase binding
GO:0042803--F:protein homodimerization activity
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001076--F:transcription factor activity, RNA polymerase II transcription factor binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0034629--P:cellular protein complex localization
GO:0008285--P:negative regulation of cell proliferation
GO:1900477--P:negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0008284--P:positive regulation of cell proliferation
GO:1902231--P:positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010608--P:posttranscriptional regulation of gene expression
GO:0051260--P:protein homooligomerization
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:138151

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001902	Ailuropoda melanoleuca	90.51	0.00e+00	815.00
IUUC-Apl-004203	Anas platyrhynchos	80.44	0.00e+00	942.00
IUUC-Ame-011046	Astyanax mexicanus	55.18	5.00e-149	521.00
IUUC-Bta-012908	Bos taurus	93.77	0.00e+00	961.00
IUUC-Cja-019140	Callithrix jacchus	96.26	0.00e+00	1072.00
IUUC-Cfa-020493	Canis familiaris	93.33	7.00e-172	597.00
IUUC-Cpo-022399	Cavia porcellus	91.36	0.00e+00	1047.00
IUUC-Csa-024135	Chlorocebus sabaeus	98.64	0.00e+00	1068.00
IUUC-Dre-027761	Danio rerio	70.45	4.00e-80	292.00
IUUC-Dno-029271	Dasypus novemcinctus	79.39	0.00e+00	740.00
IUUC-Ete-032427	Echinops telfairi	86.49	0.00e+00	894.00
IUUC-Eca-033986	Equus caballus	93.88	0.00e+00	1022.00
IUUC-Eeu-035211	Erinaceus europaeus	90.49	0.00e+00	995.00
IUUC-Fca-035733	Felis catus	92.01	0.00e+00	902.00
IUUC-Fal-037348	Ficedula albicollis	82.03	0.00e+00	942.00
IUUC-Fox-037719	Fusarium oxysporum	32.84	2.00e-07	50.10
IUUC-Gmo-039529	Gadus morhua	82.44	2.00e-94	339.00
IUUC-Gga-040405	Gallus gallus	83.53	0.00e+00	969.00
IUUC-Gac-041308	Gasterosteus aculeatus	67.80	2.00e-172	598.00
IUUC-Ggo-044687	Gorilla gorilla	74.49	0.00e+00	794.00
IUUC-Itr-048872	Ictidomys tridecemlineatus	91.69	0.00e+00	997.00
IUUC-Lch-049615	Latimeria chalumnae	75.46	0.00e+00	904.00
IUUC-Loc-051881	Lepisosteus oculatus	69.11	0.00e+00	687.00
IUUC-Lma-053325	Leptosphaeria maculans	35.09	4.00e-06	45.40
IUUC-Laf-054170	Loxodonta africana	87.94	0.00e+00	948.00
IUUC-Mga-059627	Meleagris gallopavo	82.68	0.00e+00	962.00
IUUC-Mdo-063014	Monodelphis domestica	86.93	2.00e-177	615.00
IUUC-Mmu-063897	Mus musculus	92.53	0.00e+00	1057.00
IUUC-Mpu-066806	Mustela putorius furo	91.84	0.00e+00	927.00
IUUC-Nle-069114	Nomascus leucogenys	97.42	0.00e+00	970.00
IUUC-Opr-071127	Ochotona princeps	94.57	5.00e-71	261.00
IUUC-Ont-071693	Oreochromis niloticus	79.20	4.00e-105	375.00
IUUC-Oan-073510	Ornithorhynchus anatinus	85.98	0.00e+00	1001.00
IUUC-Ola-086572	Oryzias latipes	63.78	0.00e+00	630.00
IUUC-Oga-088653	Otolemur garnettii	91.33	0.00e+00	1034.00
IUUC-Oar-089811	Ovis aries	90.55	0.00e+00	796.00
IUUC-Ptr-090703	Pan troglodytes	97.44	0.00e+00	1025.00
IUUC-Pan-092388	Papio anubis	96.11	0.00e+00	1083.00
IUUC-Psi-093786	Pelodiscus sinensis	83.53	0.00e+00	977.00
IUUC-Pma-094566	Petromyzon marinus	70.37	2.00e-64	239.00
IUUC-Pfo-096554	Poecilia formosa	63.20	8.00e-177	613.00
IUUC-Pca-101090	Procavia capensis	89.23	0.00e+00	955.00
IUUC-Pva-102843	Pteropus vampyrus	90.82	0.00e+00	984.00
IUUC-Rno-105139	Rattus norvegicus	91.51	0.00e+00	1056.00
IUUC-Sha-107545	Sarcophilus harrisii	85.59	0.00e+00	984.00
IUUC-Tgu-117401	Taeniopygia guttata	82.82	0.00e+00	957.00
IUUC-Tru-118080	Takifugu rubripes	66.46	7.00e-165	573.00
IUUC-Tni-120321	Tetraodon nigroviridis	64.72	2.00e-167	582.00
IUUC-Ttr-128369	Tursiops truncatus	91.89	0.00e+00	710.00
IUUC-Xtr-131793	Xenopus tropicalis	78.35	1.00e-150	525.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence