iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000003797.3	ENSMMUT00000054134.1	ENSMMUP00000041801.1
ENSMMUG00000003797.3	ENSMMUT00000005374.3	ENSMMUP00000005062.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.10e-110	371.1	145	684

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tG+kNlgN+CYmN++LQ+Lsn+p+l++++le     +    ++++k +l+ks+qkl++e+w k++ ++v p++l + +k ++++f+gy+
   Q: 145  TGMKNLGNSCYMNAALQALSNCPPLTQFFLE-----CGGLVRTDKKPALCKSYQKLVSEVWhKKRPSYVVPTSLSHGIKLVNPMFRGYA 228
           7******************************.....999999*******************99999*********************** PP
   S: 89   qqDaqEflaflldqleeelkk.............eknkpkeeeeeedkselsde................................... 129
           qqD+qEfl++l+dql+eelk+             +++++++e++e d+s ++de                                   
   Q: 229  QQDTQEFLRCLMDQLHEELKEpvvatvalteardSDSSDTDEKREGDRSPSEDEflscdsssdrgegdgqgrgggssqaetellipdea 317
           *******************99886666665555555555555555555555555*********************************** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 318  graisekermkdrkfswgqqrtnseqvdedadvdttmaalddqpveaqppsprsaspcrtpepdndahlrsssrpcspvhhheghakls 406
           ***************************************************************************************** PP
   S: 130  ..........................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke....... 185
                                     ++++k+++++s+isd+F+g++ s ++cl+cd+vs++ e+f+dlslp+pgke+ + +       
   Q: 407  ssppraspvrmapsyvlkkaqvlsagSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLARLhsaiyqn 495
           *****************************************************************************98888******* PP
   S: 186  ..........................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLil 232
                                                     +l+dcL++f++++el+g+n+y+ce+ckk+++ +k +++ +lPe+L++
   Q: 496  vpakpgacgdsyaaqgwlafiveyirrfvvsctpswfwgpvvTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCRVLRLPEILCI 584
           ***************************************************************************************** PP
   S: 233  hLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevke 319
           hLkRf  ++e + + kin++v+fple Ldl+pf+++++++q   ++Y+L++v++H+G+++sGHY+ay++n  +g+W++fdD++Vtev+e
   Q: 585  HLKRF--RHEVMYSFKINSHVSFPLEgLDLRPFLAKECTSQ--ITTYDLLSVICHHGTAGSGHYIAYCQNvINGQWYEFDDQYVTEVHE 669
           *****..9999***************************999..9**************************78999************** PP
   S: 320  eevleetgstaYvlfYkr 337
           + v++   +++YvlfY++
   Q: 670  TVVQN---AEGYVLFYRK 684
           *****...********98 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MGDARDLCPH LDSIGEVTKE DLLLKSKGTC QSCGVTGPNL WACLQVSCPY VGCGESFADH 60
STIHAQAKKH NLTVNLTTFR LWCYACEKEV FLEQRLAAPL PGSSSKFSEQ DSLPPSHPLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCAGAACCAG GGCCGCCCCC CTCTTATTTC TGCCGGGGCC TGACCTAGCG TTGAAAGCAT 60
CCGCGTGGCG TCTCGCGTCT CGGGCGCTGA CTTTTCTTTC CTCGGGCTCT GAGCCCTGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mcc:716505

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002209	Ailuropoda melanoleuca	92.79	0.00e+00	1675.00
IUUC-Apl-003351	Anas platyrhynchos	86.18	0.00e+00	1570.00
IUUC-Aca-005077	Anolis carolinensis	76.62	0.00e+00	1113.00
IUUC-Ame-011777	Astyanax mexicanus	75.73	0.00e+00	1354.00
IUUC-Bta-013063	Bos taurus	93.77	0.00e+00	1667.00
IUUC-Cja-019868	Callithrix jacchus	96.50	0.00e+00	1773.00
IUUC-Cfa-020761	Canis familiaris	93.66	0.00e+00	1693.00
IUUC-Cpo-022267	Cavia porcellus	86.59	0.00e+00	1559.00
IUUC-Csa-024251	Chlorocebus sabaeus	99.78	0.00e+00	1828.00
IUUC-Cho-024483	Choloepus hoffmanni	95.28	5.00e-123	435.00
IUUC-Dre-028061	Danio rerio	74.11	0.00e+00	1214.00
IUUC-Dno-029423	Dasypus novemcinctus	95.08	0.00e+00	1714.00
IUUC-Dor-030877	Dipodomys ordii	91.50	0.00e+00	1094.00
IUUC-Dme-031837	Drosophila melanogaster	50.00	1.00e-137	484.00
IUUC-Ete-032802	Echinops telfairi	81.14	1.00e-134	473.00
IUUC-Eca-034283	Equus caballus	93.01	0.00e+00	1676.00
IUUC-Eeu-034620	Erinaceus europaeus	90.50	0.00e+00	1182.00
IUUC-Fca-036357	Felis catus	93.99	0.00e+00	1668.00
IUUC-Fal-037411	Ficedula albicollis	86.17	0.00e+00	1574.00
IUUC-Gga-041101	Gallus gallus	86.00	0.00e+00	1550.00
IUUC-Gac-041315	Gasterosteus aculeatus	73.42	0.00e+00	1322.00
IUUC-Ggo-045600	Gorilla gorilla	97.82	0.00e+00	1744.00
IUUC-Hsa-045825	Homo sapiens	98.47	0.00e+00	1759.00
IUUC-Itr-048549	Ictidomys tridecemlineatus	82.36	0.00e+00	1407.00
IUUC-Lch-050002	Latimeria chalumnae	75.95	0.00e+00	1334.00
IUUC-Loc-052574	Lepisosteus oculatus	77.56	0.00e+00	1417.00
IUUC-Laf-054428	Loxodonta africana	93.24	0.00e+00	1682.00
IUUC-Mga-059781	Meleagris gallopavo	85.56	0.00e+00	1552.00
IUUC-Mdo-063048	Monodelphis domestica	86.91	0.00e+00	1536.00
IUUC-Mmu-064079	Mus musculus	92.14	0.00e+00	1660.00
IUUC-Mpu-066616	Mustela putorius furo	92.37	0.00e+00	1711.00
IUUC-Mlu-067294	Myotis lucifugus	91.48	0.00e+00	1607.00
IUUC-Nle-070015	Nomascus leucogenys	98.25	0.00e+00	1722.00
IUUC-Opr-070328	Ochotona princeps	93.23	0.00e+00	1688.00
IUUC-Ont-071464	Oreochromis niloticus	74.07	0.00e+00	1313.00
IUUC-Oan-073259	Ornithorhynchus anatinus	79.42	0.00e+00	1316.00
IUUC-Ocu-074630	Oryctolagus cuniculus	90.71	0.00e+00	1612.00
IUUC-Ola-087240	Oryzias latipes	75.16	0.00e+00	1305.00
IUUC-Oga-088761	Otolemur garnettii	93.76	0.00e+00	1719.00
IUUC-Oar-089490	Ovis aries	88.40	0.00e+00	1504.00
IUUC-Ptr-091662	Pan troglodytes	98.47	0.00e+00	1757.00
IUUC-Pan-092199	Papio anubis	99.34	0.00e+00	1816.00
IUUC-Psi-093726	Pelodiscus sinensis	87.23	0.00e+00	1575.00
IUUC-Pma-094389	Petromyzon marinus	63.51	3.00e-100	357.00
IUUC-Pab-098632	Pongo abelii	98.25	0.00e+00	1749.00
IUUC-Pca-100614	Procavia capensis	86.00	0.00e+00	1307.00
IUUC-Pva-102922	Pteropus vampyrus	91.74	0.00e+00	979.00
IUUC-Rno-105215	Rattus norvegicus	91.91	0.00e+00	1660.00
IUUC-Sce-106176	Saccharomyces cerevisiae	32.23	2.00e-25	111.00
IUUC-Sha-106601	Sarcophilus harrisii	86.26	0.00e+00	1522.00
IUUC-Ssc-115533	Sus scrofa	91.78	0.00e+00	1642.00
IUUC-Tgu-117364	Taeniopygia guttata	86.45	0.00e+00	1550.00
IUUC-Tru-117770	Takifugu rubripes	72.67	0.00e+00	1295.00
IUUC-Tni-120001	Tetraodon nigroviridis	73.12	0.00e+00	1270.00
IUUC-Ttr-128732	Tursiops truncatus	94.21	0.00e+00	1679.00
IUUC-Xtr-132157	Xenopus tropicalis	76.56	0.00e+00	1362.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence