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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063886
UUCD1 version UUC-MuM-00535
Ensembl Protein ID ENSMUSP00000101194.3
UniProt Accession Q6TDP3; KLH17_MOUSE
Genbank Protein ID AAR03711.1
Protein Name Kelch-like protein 17; Actinfilin
Genbank Nucleotide ID AY423764
Gene Name Klhl17
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000078484.3 ENSMUST00000105569.3 ENSMUSP00000101194.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
dbPAFdbPTMPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 4.10e-21 76.2 90 154
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 1.50e-13 49.7 189 219
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkld 66
           +D++l+v+ +e++ahk+vLa++S++F+a+f++e++es+ +  v+++d++p+++ +l++F Yt ++ 
   Q: 90   CDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESR-QTHVTLHDIDPQALDQLVQFAYTAEIV 154
           8*************************************.***********************9986 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           ++Nclgi+ fAd+++c+dL +aa++++l+hF
   Q: 189  PSNCLGIRGFADTHSCSDLLKAAHRYVLQHF 219
           89***************************** PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity).
 Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity).
Protein Sequence
(Fasta)
MQPRGERPAG RTQSPEHSSP GPGPEAPPPP QPPAPEAERA RPRQARPAAP MEGAMQLLSR 60
EGHSVAHNSK RHYHDAFVAM SRMRQRGLLC DIVLHVAAKE IRAHKVVLAS CSPYFHAMFT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063886|E3,BTB_3-box|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGTCTGCGG CGACGGGCGA GCGCCCGAGT GGAGCGAGCG GCCGGGCGGG CACCCGCGTC 60
CCAATCCGTC CATCAGGGTC GCGGCTTTGG CGGCTGGAGT TATGCAGCCC CGTGGCGAGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063886|E3,BTB_3-box|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0009--Actin-binding
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-0472--Membrane
KW-0628--Postsynaptic cell membrane
KW-1185--Reference proteome
KW-0677--Repeat
KW-0770--Synapse
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR011043--Gal_Oxase/kelch_b-propeller
IPR015916--Gal_Oxidase_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0030054--C:cell junction
GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0032839--C:dendrite cytoplasm
GO:0005615--C:extracellular space
GO:0043025--C:neuronal cell body
GO:0014069--C:postsynaptic density
GO:0045211--C:postsynaptic membrane
GO:0051015--F:actin filament binding
GO:0032947--F:protein complex scaffold
GO:0030036--P:actin cytoskeleton organization
GO:0007420--P:brain development
GO:0016567--P:protein ubiquitination
KEGG mmu:231003
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002095 Ailuropoda melanoleuca 98.96 0.00e+00 1132.00
IUUC-Apl-003315 Anas platyrhynchos 79.80 0.00e+00 937.00
IUUC-Aca-005317 Anolis carolinensis 90.48 0.00e+00 1076.00
IUUC-Ame-010707 Astyanax mexicanus 90.26 0.00e+00 1058.00
IUUC-Bta-012531 Bos taurus 96.97 0.00e+00 1146.00
IUUC-Bra-017070 Brassica rapa 30.85 3.00e-17 83.20
IUUC-Cfa-021138 Canis familiaris 96.34 0.00e+00 1150.00
IUUC-Cpo-021432 Cavia porcellus 96.65 0.00e+00 1196.00
IUUC-Csa-023772 Chlorocebus sabaeus 98.26 0.00e+00 1145.00
IUUC-Dre-028401 Danio rerio 90.26 0.00e+00 1059.00
IUUC-Dno-029729 Dasypus novemcinctus 96.52 0.00e+00 1100.00
IUUC-Dor-030659 Dipodomys ordii 98.78 0.00e+00 1128.00
IUUC-Dme-031996 Drosophila melanogaster 56.17 0.00e+00 649.00
IUUC-Ete-033128 Echinops telfairi 92.89 0.00e+00 858.00
IUUC-Eca-033856 Equus caballus 97.57 0.00e+00 1105.00
IUUC-Eeu-034646 Erinaceus europaeus 92.98 0.00e+00 1036.00
IUUC-Fca-036183 Felis catus 98.61 0.00e+00 1125.00
IUUC-Fal-037046 Ficedula albicollis 80.67 0.00e+00 860.00
IUUC-Gmo-039526 Gadus morhua 83.42 0.00e+00 962.00
IUUC-Gga-040510 Gallus gallus 91.51 0.00e+00 1073.00
IUUC-Gac-042529 Gasterosteus aculeatus 87.44 0.00e+00 1046.00
IUUC-Ggo-044992 Gorilla gorilla 95.53 0.00e+00 1190.00
IUUC-Hsa-046621 Homo sapiens 95.53 0.00e+00 1190.00
IUUC-Itr-048791 Ictidomys tridecemlineatus 96.33 0.00e+00 1159.00
IUUC-Lch-049449 Latimeria chalumnae 90.61 0.00e+00 1065.00
IUUC-Loc-052690 Lepisosteus oculatus 85.64 0.00e+00 1050.00
IUUC-Laf-053925 Loxodonta africana 96.86 0.00e+00 702.00
IUUC-Mcc-054780 Macaca mulatta 88.85 0.00e+00 1068.00
IUUC-Meu-056812 Macropus eugenii 85.52 0.00e+00 830.00
IUUC-Mpo-057526 Magnaporthe poae 27.50 3.00e-07 48.50
IUUC-Mga-059704 Meleagris gallopavo 91.02 0.00e+00 1073.00
IUUC-Mmr-061724 Microcebus murinus 96.91 0.00e+00 1131.00
IUUC-Mpu-066774 Mustela putorius furo 98.61 0.00e+00 1129.00
IUUC-Nle-070159 Nomascus leucogenys 95.22 0.00e+00 1187.00
IUUC-Opr-070367 Ochotona princeps 90.54 0.00e+00 821.00
IUUC-Ont-071757 Oreochromis niloticus 89.57 0.00e+00 1052.00
IUUC-Ocu-074674 Oryctolagus cuniculus 90.88 0.00e+00 1020.00
IUUC-Opu-083716 Oryza punctata 32.90 8.00e-33 135.00
IUUC-Ola-086760 Oryzias latipes 87.61 0.00e+00 1050.00
IUUC-Oga-088570 Otolemur garnettii 94.43 0.00e+00 1140.00
IUUC-Oar-090344 Ovis aries 86.36 0.00e+00 994.00
IUUC-Ptr-090946 Pan troglodytes 95.37 0.00e+00 1188.00
IUUC-Pan-092661 Papio anubis 98.26 0.00e+00 1145.00
IUUC-Psi-094009 Pelodiscus sinensis 88.57 0.00e+00 1044.00
IUUC-Pfo-097164 Poecilia formosa 84.20 0.00e+00 1040.00
IUUC-Pab-097554 Pongo abelii 78.62 0.00e+00 751.00
IUUC-Pca-100460 Procavia capensis 87.83 0.00e+00 1018.00
IUUC-Pva-102180 Pteropus vampyrus 95.53 0.00e+00 1145.00
IUUC-Rno-105907 Rattus norvegicus 100.00 0.00e+00 1170.00
IUUC-Smo-109299 Selaginella moellendorffii 27.47 2.00e-16 80.90
IUUC-Sar-113112 Sorex araneus 83.87 0.00e+00 630.00
IUUC-Ssc-115448 Sus scrofa 91.03 0.00e+00 834.00
IUUC-Tgu-117293 Taeniopygia guttata 91.39 0.00e+00 1074.00
IUUC-Tru-117814 Takifugu rubripes 87.69 0.00e+00 1030.00
IUUC-Tni-120531 Tetraodon nigroviridis 89.57 0.00e+00 1051.00
IUUC-Tca-120913 Theobroma cacao 35.65 4.00e-37 149.00
IUUC-Tae-124075 Triticum aestivum 34.22 2.00e-39 157.00
IUUC-Tbe-127460 Tupaia belangeri 98.91 0.00e+00 1079.00
IUUC-Xtr-132356 Xenopus tropicalis 91.48 0.00e+00 1070.00
Created Date 25-Jun-2017

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