iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oan-073505

Ensembl Protein ID

ENSOANP00000001906.1

UniProt Accession

F6ZYN6; F6ZYN6_ORNAN

Protein Name

Tyrosine-protein kinase

Gene Name

LCK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000001195.2	ENSOANT00000001907.1	ENSOANP00000001906.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	6.10e-17	61.6	62	119

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +++v +l++ye+++d++L ++k ++++++   eq+++W+k+++ ++g++G++P nFv++++
   Q: 62   DNLVVALHNYEPVHDGDLGFQKSEQLRIL---EQSGEWWKAQSLTTGQEGFIPFNFVARAN 119
           6899*************************...**************************987 PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

MGCNCSSDYD DDWMENIDLC DRCHYPIAPE SKAQVGGGGV CVRVCLWGGG LLHRPVPPFS 60
PDNLVVALHN YEPVHDGDLG FQKSEQLRIL EQSGEWWKAQ SLTTGQEGFI PFNFVARANS 120

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Nucleotide Sequence
(Fasta)

ATGGGCTGTA ACTGCAGCTC CGACTACGAC GATGACTGGA TGGAAAACAT TGACCTGTGC 60
GACCGTTGCC ACTACCCCAT CGCCCCGGAA AGCAAAGCGC AGGTTGGCGG GGGCGGAGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50011--PROTEIN_KINASE_DOM
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0001772--C:immunological synapse
GO:0045121--C:membrane raft
GO:0000242--C:pericentriolar material
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004722--F:protein serine/threonine phosphatase activity
GO:0005102--F:receptor binding
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0006882--P:cellular zinc ion homeostasis
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:2001244--P:positive regulation of intrinsic apoptotic signaling pathway
GO:0050870--P:positive regulation of T cell activation
GO:0042127--P:regulation of cell proliferation
GO:0042493--P:response to drug
GO:0030217--P:T cell differentiation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Csa-023270	Chlorocebus sabaeus	59.06	4.00e-166	577.00
IUUC-Pca-100547	Procavia capensis	70.61	2.00e-131	462.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence