iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tni-120189

UUCD1 version

UUC-TeN-01137

Ensembl Protein ID

ENSTNIP00000006594.1

UniProt Accession

H3CEC0; H3CEC0_TETNG

Protein Name

Ubiquitinyl hydrolase 1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTNIG00000003985.1	ENSTNIT00000006745.1	ENSTNIP00000006594.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.30e-110	370.0	158	697

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tGlkN+gNtCYmN++LQ+Lsn+p+l++++le     +    ++++k +l+ks+qkl++ lw k+++++v p++l++ +k+++++f+gy+
   Q: 158  TGLKNIGNTCYMNAALQALSNCPPLTQFFLE-----CGGMVRTDKKPALCKSYQKLVSDLWhKNSSSYVVPTTLFQGIKTINPMFRGYS 241
           7******************************.....9999999******************999999********************** PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde................................................ 129
           qqD+qEfl++l+dql+eelk+  ++++e+++  ++   ++e                                                
   Q: 242  QQDSQEFLRCLMDQLHEELKEPMTESYEHSNMVTTDGNPEEdnhsqsddfqscescdsseradsevhignmlidntneaetpipdqdgi 330
           *******************996666666655555555555566777778999999999999**************************** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 331  qtsrewqkeknmindlyrsslqsviggstgmnldkdvettnettpiigcqeatkiqgrtsdsstyiqmsnvrpqspvlmeghipklsss 419
           ***************************************************************************************** PP
   S: 130  ........................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke......... 185
                                    ++k++kk++s++sd+F+g++ s+++cl+cd+vs++ e+f+d+slp+pgke+ +k+         
   Q: 420  ppkaasgwhnlnpvhkkvvatfssPKNKHHKKYRSIVSDVFDGTIVSSVQCLTCDRVSVTLENFQDISLPIPGKEDLAKLhssthqtsl 508
           ***********************98999***********************************************99888********* PP
   S: 186  ..........................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLil 232
                                                     +l+ cL++f+ ++el+ +n+y+cekckk+++ +k +k+++lPe+L++
   Q: 509  vkagscgdayapqgwiafvmeyikrceftgcspssfmhrpclNLTPCLRAFFGRDELKRDNMYSCEKCKKLRNGVKFCKMQNLPEILCI 597
           ***************************************************************************************** PP
   S: 233  hLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevke 319
           hLkRf  ++e ++++ki+++v+fple Ldl+pf++++++ q  +++Y+L++v++H+G++ssGHY+ay++n+ ++ W++fdD++Vtev+e
   Q: 598  HLKRF--RHELMFSTKISTHVSFPLEgLDLQPFLAKDSSCQ--TTNYDLLSVICHHGTASSGHYIAYCRNDGNNlWYEFDDHRVTEVSE 682
           *****..9999*************************88887..9**************************87779************** PP
   S: 320  eevleetgstaYvlfYkr 337
           + v++   ++aYvlfYk+
   Q: 683  SCVQN---AEAYVLFYKK 697
           *****...********98 PP

Organism

Tetraodon nigroviridis

Protein Sequence
(Fasta)

MAPLSSCDCP HLDCVGEVTK EELIQKSHGQ CQDCKVGGPN LWACLENGCM YVGCGESHAD 60
HSTMHSQETR HNLTVNLTTL RVWCYACSKE VFLERKLGPH SLHVNNEMLP CPMEPGQXRV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCACCTT TGTCCAGCTG CGATTGTCCT CATTTGGATT GTGTCGGGGA GGTCACTAAG 60
GAAGAACTCA TTCAGAAATC CCACGTATGT AACCCTTTAT TCTGCATTGT GCCCTTTAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001742	Ailuropoda melanoleuca	67.53	0.00e+00	1220.00
IUUC-Apl-003987	Anas platyrhynchos	65.95	0.00e+00	1164.00
IUUC-Aca-004713	Anolis carolinensis	64.43	0.00e+00	1139.00
IUUC-Bta-013132	Bos taurus	67.14	0.00e+00	1225.00
IUUC-Cja-018811	Callithrix jacchus	67.24	0.00e+00	1218.00
IUUC-Cfa-021158	Canis familiaris	67.53	0.00e+00	1214.00
IUUC-Cpo-021910	Cavia porcellus	61.40	0.00e+00	1059.00
IUUC-Csa-023130	Chlorocebus sabaeus	67.35	0.00e+00	1216.00
IUUC-Cho-024383	Choloepus hoffmanni	48.20	2.00e-97	350.00
IUUC-Csv-025889	Ciona savignyi	39.76	2.00e-34	137.00
IUUC-Dre-028639	Danio rerio	74.73	0.00e+00	1352.00
IUUC-Dno-029416	Dasypus novemcinctus	67.24	0.00e+00	1187.00
IUUC-Eca-034248	Equus caballus	66.96	0.00e+00	1221.00
IUUC-Eeu-035357	Erinaceus europaeus	52.31	0.00e+00	820.00
IUUC-Fca-036013	Felis catus	65.21	0.00e+00	1172.00
IUUC-Fal-037509	Ficedula albicollis	65.66	0.00e+00	1179.00
IUUC-Gmo-038944	Gadus morhua	74.44	0.00e+00	1333.00
IUUC-Gga-040647	Gallus gallus	65.38	0.00e+00	1162.00
IUUC-Gac-041752	Gasterosteus aculeatus	81.86	0.00e+00	1492.00
IUUC-Hsa-045694	Homo sapiens	67.35	0.00e+00	1211.00
IUUC-Itr-049041	Ictidomys tridecemlineatus	67.56	0.00e+00	1201.00
IUUC-Lch-050400	Latimeria chalumnae	64.34	0.00e+00	1154.00
IUUC-Loc-052616	Lepisosteus oculatus	70.83	0.00e+00	1304.00
IUUC-Laf-053493	Loxodonta africana	66.38	0.00e+00	1208.00
IUUC-Mcc-055542	Macaca mulatta	67.35	0.00e+00	1217.00
IUUC-Meu-056645	Macropus eugenii	57.61	0.00e+00	993.00
IUUC-Mmr-061241	Microcebus murinus	64.86	0.00e+00	1154.00
IUUC-Mmu-063786	Mus musculus	67.14	0.00e+00	1201.00
IUUC-Mlu-067732	Myotis lucifugus	66.95	0.00e+00	1211.00
IUUC-Nle-069528	Nomascus leucogenys	67.10	0.00e+00	1217.00
IUUC-Opr-070606	Ochotona princeps	64.11	0.00e+00	1095.00
IUUC-Ont-071495	Oreochromis niloticus	82.96	0.00e+00	1496.00
IUUC-Ocu-074457	Oryctolagus cuniculus	66.34	0.00e+00	1213.00
IUUC-Ola-086739	Oryzias latipes	80.17	0.00e+00	1505.00
IUUC-Oga-088720	Otolemur garnettii	66.67	0.00e+00	1226.00
IUUC-Oar-089921	Ovis aries	67.46	0.00e+00	1227.00
IUUC-Ptr-090526	Pan troglodytes	67.24	0.00e+00	1211.00
IUUC-Pan-092396	Papio anubis	67.39	0.00e+00	1221.00
IUUC-Psi-092971	Pelodiscus sinensis	66.45	0.00e+00	1195.00
IUUC-Pfo-097415	Poecilia formosa	79.70	0.00e+00	1447.00
IUUC-Pab-098740	Pongo abelii	67.14	0.00e+00	1223.00
IUUC-Pca-100598	Procavia capensis	65.89	0.00e+00	698.00
IUUC-Pva-102820	Pteropus vampyrus	63.44	0.00e+00	991.00
IUUC-Rno-104894	Rattus norvegicus	67.06	0.00e+00	1201.00
IUUC-Sha-107244	Sarcophilus harrisii	61.79	0.00e+00	1090.00
IUUC-Sar-113665	Sorex araneus	66.02	0.00e+00	1190.00
IUUC-Ssc-115793	Sus scrofa	66.31	0.00e+00	1183.00
IUUC-Tgu-117487	Taeniopygia guttata	67.49	0.00e+00	1158.00
IUUC-Tru-117694	Takifugu rubripes	86.31	0.00e+00	1642.00
IUUC-Tsy-119598	Tarsius syrichta	59.85	0.00e+00	995.00
IUUC-Tbe-128125	Tupaia belangeri	70.35	4.00e-76	279.00
IUUC-Ttr-128269	Tursiops truncatus	65.43	0.00e+00	1145.00
IUUC-Vpa-130598	Vicugna pacos	65.48	0.00e+00	1182.00
IUUC-Xtr-132044	Xenopus tropicalis	64.66	0.00e+00	1146.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence