• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063486
Ensembl Protein ID ENSMUSP00000091429.5
UniProt Accession E9Q555; F7A6H4; Q8BVK6; RN213_MOUSE
Genbank Protein ID BAC37048.1
Protein Name E3 ubiquitin-protein ligase RNF213; Mysterin; RING finger protein 213; RING-type E3 ubiquitin transferase RNF213
Genbank Nucleotide ID AL645911
Gene Name Rnf213; Mystr
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000070327.14 ENSMUST00000131035.9 ENSMUSP00000115063.3
ENSMUSG00000070327.14 ENSMUST00000093902.11 ENSMUSP00000091429.5
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RAID2
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 66.19 0.00e+00 6821.00 IUUC-Hsa-046140
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase involved in angiogenesis. Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression. Also has ATPase activity.
 E3 ubiquitin-protein ligase involved in angiogenesis. Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression. Also has ATPase activity.
Protein Sequence
(Fasta)
MECPQCGHVS SEKAPKFCSE CGQKLPSAAT VQGDLKNDNT LVVSSTPEGK TEQGAVLREE 60
EVLLSSTDPG KELEKPEESD SNASWTTQMS KKEKRRRKRQ GTISSSEAPS SGLWSLDMPP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063486|E3,RING|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGAGTGTC CACAGTGCGG GCATGTCTCC TCAGAGAAGG CACCCAAGTT CTGTAGCGAG 60
TGCGGACAGA AATTGCCTTC TGCAGCTACT GTGCAAGGTG AGGCTAGGTT GGGGAGGGGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063486|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0037--Angiogenesis
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003593--AAA+_ATPase
IPR027417--P-loop_NTPase
IPR031248--RNF213
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
SMART

SM00382--AAA
SM00184--RING
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0005730--C:nucleolus
GO:0016887--F:ATPase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0001525--P:angiogenesis
GO:2000051--P:negative regulation of non-canonical Wnt signaling pathway
GO:0051865--P:protein autoubiquitination
GO:0051260--P:protein homooligomerization
GO:0016567--P:protein ubiquitination
GO:0002040--P:sprouting angiogenesis
GO:0006511--P:ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Apl-004090 Anas platyrhynchos 55.10 0.00e+00 4621.00
IUUC-Ame-010883 Astyanax mexicanus 48.20 0.00e+00 3892.00
IUUC-Cja-019209 Callithrix jacchus 73.14 0.00e+00 4883.00
IUUC-Cfa-020058 Canis familiaris 65.37 0.00e+00 5913.00
IUUC-Cpo-022285 Cavia porcellus 71.40 0.00e+00 3987.00
IUUC-Cre-022927 Chlamydomonas reinhardtii 40.82 3.00e-03 38.10
IUUC-Csa-023613 Chlorocebus sabaeus 68.18 0.00e+00 6917.00
IUUC-Cho-024453 Choloepus hoffmanni 73.77 0.00e+00 2667.00
IUUC-Cin-025584 Ciona intestinalis 32.24 0.00e+00 1444.00
IUUC-Csv-026161 Ciona savignyi 23.96 6.00e-23 102.00
IUUC-Dre-027864 Danio rerio 45.38 0.00e+00 4249.00
IUUC-Dno-029563 Dasypus novemcinctus 61.92 0.00e+00 5968.00
IUUC-Dor-030748 Dipodomys ordii 72.87 0.00e+00 2335.00
IUUC-Eca-034252 Equus caballus 68.89 0.00e+00 6621.00
IUUC-Eeu-035087 Erinaceus europaeus 71.71 0.00e+00 1956.00
IUUC-Fca-036042 Felis catus 69.54 0.00e+00 1602.00
IUUC-Fal-037402 Ficedula albicollis 52.65 0.00e+00 4863.00
IUUC-Gmo-039713 Gadus morhua 48.97 0.00e+00 3782.00
IUUC-Gga-040437 Gallus gallus 55.30 0.00e+00 3559.00
IUUC-Gac-042182 Gasterosteus aculeatus 40.04 0.00e+00 2555.00
IUUC-Ggo-045212 Gorilla gorilla 72.83 0.00e+00 4881.00
IUUC-Hsa-046140 Homo sapiens 66.14 0.00e+00 6793.00
IUUC-Itr-047894 Ictidomys tridecemlineatus 74.39 0.00e+00 4923.00
IUUC-Lch-050262 Latimeria chalumnae 49.61 0.00e+00 4496.00
IUUC-Loc-052115 Lepisosteus oculatus 47.47 0.00e+00 4509.00
IUUC-Laf-054258 Loxodonta africana 47.74 0.00e+00 1274.00
IUUC-Mcc-055793 Macaca mulatta 65.68 0.00e+00 6751.00
IUUC-Meu-055905 Macropus eugenii 57.86 0.00e+00 1164.00
IUUC-Mdo-062190 Monodelphis domestica 60.08 0.00e+00 5865.00
IUUC-Mpu-065783 Mustela putorius furo 62.15 0.00e+00 6281.00
IUUC-Mlu-067959 Myotis lucifugus 67.42 0.00e+00 4423.00
IUUC-Nle-069617 Nomascus leucogenys 72.39 0.00e+00 5269.00
IUUC-Opr-071117 Ochotona princeps 70.92 0.00e+00 2250.00
IUUC-Ont-072667 Oreochromis niloticus 47.65 0.00e+00 4316.00
IUUC-Ocu-074421 Oryctolagus cuniculus 66.53 0.00e+00 1638.00
IUUC-Ola-086411 Oryzias latipes 48.98 0.00e+00 3970.00
IUUC-Oga-088090 Otolemur garnettii 71.24 0.00e+00 4761.00
IUUC-Oar-089763 Ovis aries 64.76 0.00e+00 6685.00
IUUC-Pan-091737 Papio anubis 66.77 0.00e+00 6895.00
IUUC-Psi-093008 Pelodiscus sinensis 57.30 0.00e+00 4967.00
IUUC-Pma-094477 Petromyzon marinus 38.72 0.00e+00 2086.00
IUUC-Pfo-096327 Poecilia formosa 53.24 0.00e+00 3615.00
IUUC-Pab-098316 Pongo abelii 70.07 0.00e+00 3997.00
IUUC-Pca-101059 Procavia capensis 75.14 0.00e+00 2151.00
IUUC-Pva-102703 Pteropus vampyrus 66.93 0.00e+00 3497.00
IUUC-Rno-105537 Rattus norvegicus 84.10 0.00e+00 8764.00
IUUC-Sha-106990 Sarcophilus harrisii 66.93 0.00e+00 4465.00
IUUC-Tgu-116501 Taeniopygia guttata 56.64 0.00e+00 795.00
IUUC-Tru-118139 Takifugu rubripes 33.65 0.00e+00 1066.00
IUUC-Tsy-118810 Tarsius syrichta 72.69 0.00e+00 2250.00
IUUC-Tni-119963 Tetraodon nigroviridis 48.97 0.00e+00 3960.00
IUUC-Tbe-127986 Tupaia belangeri 69.56 0.00e+00 1104.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved