iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-091522

UUCD1 version

UUC-PaT-01093

Ensembl Protein ID

ENSPTRP00000051643.3

UniProt Accession

H2R8H8; H2R8H8_PANTR

Genbank Protein ID

JAA07154.1; JAA07155.1; JAA29747.1; JAA42524.1

Protein Name

Ubiquitin specific peptidase 21

Genbank Nucleotide ID

AACZ03005316; GABC01004183; GABD01003353; GABE01002215

Gene Name

USP21

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000001573.5	ENSPTRT00000058623.3	ENSPTRP00000051643.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.20e-91	306.0	212	556

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgy 87
           +Gl+NlgNtC++N+vLQcLs++++lr+++l+  ++++++     ++ +el++++++++ +lw  ++ +av+p+++ ++++k+ ++fsgy
   Q: 212  VGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRrDFRQEVPG---GGRAQELTEAFADVIGALWhPDSCEAVNPTRFRAVFQKYVPSFSGY 297
           6******************************667777776...5789***************888899********************* PP
   S: 88   eqqDaqEflaflldqleeelkk..................eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikcle 158
           +qqDaqEfl+ l+++l+ e+++                  ++     ee e ++ ++ +  +++  ++++s i+dlF gqlks +kc++
   Q: 298  SQQDAQEFLKLLMERLHLEINRrgrrappilangpvpsppRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQA 386
           ********************9999999999999988877766666677777777777777***************************** PP
   S: 159  cdnvssreepfldlslpvpgkeet.kkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksr 246
           c+ +s+++e f+dlslp+p+k     k sl+dc++ ftkeeele+en+  c++c++k++++kkl+++++P++L+lhL+Rf  s +++s 
   Q: 387  CGYRSTTFEVFCDLSLPIPKKGFAgGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRF--SASRGSI 473
           *******************887541456****************************************************..5566899 PP
   S: 247  ekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlf 334
           +k +  v+fpl+ L+l  f +++      +  Y+L+a ++HsGs++ GHY+a+++  + +W  ++Ds+V++v+e++v +   s++Yvlf
   Q: 474  KKSSVGVDFPLQrLSLGDFASDKAG----SPVYQLYALCNHSGSVHYGHYTALCRC-QTGWHVYNDSRVSPVSENQVAS---SEGYVLF 554
           9**********99*******99543....78*************************.777*******************...******* PP
   S: 335  Yk 336
           Y+
   Q: 555  YQ 556
           *8 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MPQASEHRLG RTREPPVNIQ PRVGSKLPFA PRARSKERRN PASGPNPMLR PLPPRPGPPD 60
ERLKKLELGR GRTSGPRPRG PLRADHGVPL PGSPPPTVAL PLPSRTNLAR SKSVSSGDLR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGCAGGCGC TTTGAGAGAC GGTGAAGCCG GTGGCCGGTG GCCGGGCGGG ACCAACAAAG 60
ATGGCGGCGG CCCCTGCGGC GGGAGCGATC TGGGCAACGG CTGCGGCTAA AGCTGCAGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001858	Ailuropoda melanoleuca	96.64	0.00e+00	1006.00
IUUC-Aca-004612	Anolis carolinensis	59.50	7.00e-174	603.00
IUUC-Ame-011548	Astyanax mexicanus	52.26	9.00e-104	370.00
IUUC-Bta-012626	Bos taurus	97.52	0.00e+00	989.00
IUUC-Cja-018853	Callithrix jacchus	99.12	0.00e+00	1044.00
IUUC-Cfa-021167	Canis familiaris	97.17	0.00e+00	998.00
IUUC-Cpo-021305	Cavia porcellus	95.94	0.00e+00	956.00
IUUC-Csa-023454	Chlorocebus sabaeus	100.00	0.00e+00	1054.00
IUUC-Cho-024836	Choloepus hoffmanni	95.85	5.00e-108	384.00
IUUC-Dre-028454	Danio rerio	53.67	9.00e-108	383.00
IUUC-Dno-029955	Dasypus novemcinctus	91.67	0.00e+00	642.00
IUUC-Dor-031053	Dipodomys ordii	96.81	0.00e+00	1052.00
IUUC-Ete-032416	Echinops telfairi	95.88	2.00e-144	505.00
IUUC-Eca-033817	Equus caballus	96.28	0.00e+00	1014.00
IUUC-Fca-036400	Felis catus	96.47	0.00e+00	991.00
IUUC-Gmo-038926	Gadus morhua	54.80	2.00e-104	372.00
IUUC-Gac-041331	Gasterosteus aculeatus	53.31	4.00e-107	380.00
IUUC-Ggo-045174	Gorilla gorilla	100.00	0.00e+00	1054.00
IUUC-Hsa-046443	Homo sapiens	99.82	0.00e+00	1046.00
IUUC-Itr-048329	Ictidomys tridecemlineatus	96.83	0.00e+00	1014.00
IUUC-Lch-050539	Latimeria chalumnae	62.00	4.00e-105	375.00
IUUC-Loc-051808	Lepisosteus oculatus	55.80	1.00e-115	409.00
IUUC-Laf-053730	Loxodonta africana	95.07	0.00e+00	1021.00
IUUC-Mcc-055541	Macaca mulatta	100.00	0.00e+00	1054.00
IUUC-Meu-056279	Macropus eugenii	90.28	0.00e+00	966.00
IUUC-Mmr-060913	Microcebus murinus	97.70	0.00e+00	959.00
IUUC-Mdo-061807	Monodelphis domestica	90.28	0.00e+00	894.00
IUUC-Mmu-063599	Mus musculus	95.96	0.00e+00	963.00
IUUC-Mpu-066329	Mustela putorius furo	97.52	0.00e+00	999.00
IUUC-Mlu-067359	Myotis lucifugus	93.32	0.00e+00	890.00
IUUC-Nle-068975	Nomascus leucogenys	97.70	0.00e+00	1022.00
IUUC-Opr-071096	Ochotona princeps	93.81	0.00e+00	960.00
IUUC-Ocu-074228	Oryctolagus cuniculus	97.18	0.00e+00	994.00
IUUC-Ola-086684	Oryzias latipes	50.71	5.00e-102	364.00
IUUC-Oga-088007	Otolemur garnettii	79.15	0.00e+00	768.00
IUUC-Oar-090226	Ovis aries	96.99	0.00e+00	771.00
IUUC-Pan-091954	Papio anubis	99.65	0.00e+00	1046.00
IUUC-Psi-093216	Pelodiscus sinensis	60.96	0.00e+00	674.00
IUUC-Pfo-096257	Poecilia formosa	50.42	3.00e-102	364.00
IUUC-Pab-098691	Pongo abelii	99.82	0.00e+00	1053.00
IUUC-Pca-101133	Procavia capensis	88.67	0.00e+00	952.00
IUUC-Pva-102681	Pteropus vampyrus	93.45	0.00e+00	938.00
IUUC-Rno-105132	Rattus norvegicus	96.81	0.00e+00	990.00
IUUC-Sha-107145	Sarcophilus harrisii	89.94	0.00e+00	881.00
IUUC-Ssc-115586	Sus scrofa	97.70	0.00e+00	980.00
IUUC-Tgu-117491	Taeniopygia guttata	81.89	1.00e-113	402.00
IUUC-Tni-120746	Tetraodon nigroviridis	51.64	5.00e-96	344.00
IUUC-Tbe-127465	Tupaia belangeri	98.60	1.00e-126	446.00
IUUC-Ttr-128274	Tursiops truncatus	95.04	0.00e+00	958.00
IUUC-Xtr-131989	Xenopus tropicalis	48.97	1.00e-127	449.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence