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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046700
UUCD1 version UUC-HoS-00290
Ensembl Protein ID ENSP00000272395.2
UniProt Accession Q96BQ3; Q53TJ7; TRI43_HUMAN
Genbank Protein ID AAY14782.1; AAH15353.1
Protein Name Tripartite motif-containing protein 43
Genbank Nucleotide ID AC009237; BC015353
Gene Name TRIM43
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000144015.4 ENST00000272395.2 ENSP00000272395.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbmicroRNATRANSFACTargetScan
RepTarmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Post-translational Modifications (PTMs)
BioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18248090
Classification
Family E-value Score Start End
E3 activity/RING/U-box 9.90e-06 27.2 11 74
E3 activity/RING/RING 8.60e-05 24.6 15 56
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/U-box
   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwl..asggk..tcPvtrqplteedlvPnltlrrli 65
           +e+ C I l+   dPv++++G+++ r ++  +l  ++ ++   cP +r+p  + d++ n+ l++l+
   Q: 11   KELTCVICLNYLVDPVTICCGHSFCRPCL--CLswEEAQSpaNCPACREPSPKMDFKTNILLKNLV 74
           6899************************9..553333333579********************997 PP
   

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C iCl+ + d p++  CgH f++ Cl   w     +++  ++CP Cr
   Q: 15   CVICLNYLVD-PVTICCGHSFCRPCLcLSW----EEAQSPANCPACR 56
           **********.999****************....8899999*****8 PP
   
Organism Homo sapiens
Protein Sequence
(Fasta)
MDSDFSHAFQ KELTCVICLN YLVDPVTICC GHSFCRPCLC LSWEEAQSPA NCPACREPSP 60
KMDFKTNILL KNLVTIARKA SLWQFLSSEK QICGTHRQTK KMFCDMDKSL LCLLCSNSQE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046700|E3,RING;E3,U-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACAGAGTAGC TTTGCAACTG GCTTTGGGGA CTTCCGAAAG CTACCAGCAC TGCACTGTGA 60
GACTCTCATC CCTGAGCTGA ATTCATCTGA TTCGACGGCA AGCTTTGGTG AGAACATAGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046700|E3,RING;E3,U-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00622--SPRY
PRINTS

PR01407--BUTYPHLNCDUF
SMART

SM00336--BBOX
SM00184--RING
SM00449--SPRY
Gene Ontology

GO:0005622--C:intracellular
GO:0008270--F:zinc ion binding
KEGG hsa:129868
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Bta-012834 Bos taurus 46.71 2.00e-110 392.00
IUUC-Cja-019010 Callithrix jacchus 73.75 0.00e+00 658.00
IUUC-Cfa-020435 Canis familiaris 49.78 2.00e-114 405.00
IUUC-Csa-024131 Chlorocebus sabaeus 87.39 0.00e+00 810.00
IUUC-Cho-024585 Choloepus hoffmanni 63.39 4.00e-168 584.00
IUUC-Dno-029845 Dasypus novemcinctus 62.72 2.00e-164 572.00
IUUC-Dor-030118 Dipodomys ordii 51.35 1.00e-119 422.00
IUUC-Eca-033627 Equus caballus 60.90 5.00e-155 540.00
IUUC-Fca-035378 Felis catus 52.13 3.00e-120 425.00
IUUC-Ggo-044625 Gorilla gorilla 97.97 1.00e-143 502.00
IUUC-Laf-053917 Loxodonta africana 63.70 1.00e-164 572.00
IUUC-Mcc-054788 Macaca mulatta 87.44 0.00e+00 807.00
IUUC-Mmr-061646 Microcebus murinus 59.29 2.00e-145 508.00
IUUC-Mmu-064071 Mus musculus 42.44 1.00e-92 333.00
IUUC-Mlu-067801 Myotis lucifugus 57.14 9.00e-141 493.00
IUUC-Nle-069150 Nomascus leucogenys 91.48 0.00e+00 827.00
IUUC-Opr-070996 Ochotona princeps 51.46 6.00e-124 437.00
IUUC-Ocu-074806 Oryctolagus cuniculus 59.96 1.00e-151 530.00
IUUC-Oga-088482 Otolemur garnettii 62.44 3.00e-164 571.00
IUUC-Oar-089186 Ovis aries 48.46 1.00e-109 390.00
IUUC-Ptr-090899 Pan troglodytes 97.76 0.00e+00 915.00
IUUC-Pan-092427 Papio anubis 88.12 7.00e-160 556.00
IUUC-Pab-098214 Pongo abelii 94.17 0.00e+00 882.00
IUUC-Pca-100275 Procavia capensis 58.65 2.00e-127 448.00
IUUC-Rno-105981 Rattus norvegicus 47.20 4.00e-108 385.00
IUUC-Smo-109430 Selaginella moellendorffii 43.55 1.00e-09 57.40
IUUC-Ssc-115481 Sus scrofa 51.66 3.00e-130 458.00
IUUC-Tsy-118839 Tarsius syrichta 75.56 0.00e+00 663.00
IUUC-Tbe-128068 Tupaia belangeri 54.01 1.00e-72 266.00
IUUC-Ttr-129012 Tursiops truncatus 42.81 2.00e-60 226.00
Created Date 25-Jun-2017

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