iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tni-119733

UUCD1 version

UUC-TeN-01141

Ensembl Protein ID

ENSTNIP00000015648.1

UniProt Accession

H3D559; H3D559_TETNG

Protein Name

Ubiquitinyl hydrolase 1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTNIG00000012674.1	ENSTNIT00000015855.1	ENSTNIP00000015648.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.20e-96	324.0	268	679

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenp.............................................. 42
           tGl+NlgNtCYmNS+LQ+Ls+++ +re++l+   +++++  ++                                              
   Q: 268  TGLRNLGNTCYMNSILQVLSHLHVFRECFLRlDLTQAVELLASavhgqmvgklsspssltprkglqassgsgsglsggasrsrsmeliq 356
           7******************************7344444444446778888888889999999999999999999999999999999999 PP
   S: 43   ....kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedksels 127
               ++++ +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ lld+++ el++  +++++++ +       
   Q: 357  pkepSSKHISLCHELHTLFQVMWSGKWALVSPFAMLHSVWQLIPAFRGYAQQDAQEFLCELLDKVQHELESAGKHTTSTT-GV------ 438
           999899999************************************************************55333333333.22...... PP
   S: 128  deaeekkkkknkslisdlFqgqlksqik.clecdnvssreepfldlslpvpgkeetkke........slqdcLesftkeeelegenkyy 207
            + +++  ++  s+++++F+gql sq++ cl+c+++s + epf+dlsl++p++ +++ +         l+++L++ft++e leg+  y 
   Q: 439  PQTRKRLIRQVLSVVNTIFHGQLLSQVVtCLACGHRSDTVEPFWDLSLEFPERYHSNSResaaqascHLTEMLAKFTETEALEGSI-YA 526
           24678999999*************99877**********************9998766699999*******************966.** PP
   S: 208  cekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke........... 274
           c++c+++++           a+k+l+++klP+vL lhLkRf++s + ++reki  +v f + L+++p+c+++++   +           
   Q: 527  CDHCNASRRrttakpvllteAQKQLMVHKLPQVLRLHLKRFRWSGR-NHREKIGVHVRFDQLLNMEPYCCRESSPR-Dlscsspsaasp 613
           *****888888888888888***********************997.8889*********99*********44333.246666777777 PP
   S: 275  ....kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
               +  Y+L+avv+H+G +++sGHY++y++n++g+ W++++Dsk ++++eeev++   ++aY+lfY++
   Q: 614  phhkHFLYDLSAVVMHHGkGFGSGHYTSYCYNTEGGfWVHCNDSKLNVCSEEEVCR---AQAYILFYTQ 679
           77779***************************9999********************...********98 PP

Organism

Tetraodon nigroviridis

Protein Sequence
(Fasta)

ACGMDRCKHV GRLRLASDHS ILNPQKWHCV DCNTSESIWA CLSCSHVACG RYIEEHALQH 60
FQQQRHPLAI EVNELYVFCY LCDDYVLNDN ATGDLKLLRS TLSAIQSQRY EVTTRSGRTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGTGTGGAA TGGACAGGTG CAAGCACGTG GGGCGGCTGA GGCTGGCCTC AGACCACTCC 60
ATCCTCAACC CTCAGAAATG GCACTGCGTC GACTGCAACA CATCCGAGTC CATTTGGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001220	Ailuropoda melanoleuca	62.16	0.00e+00	848.00
IUUC-Apl-003673	Anas platyrhynchos	65.81	0.00e+00	894.00
IUUC-Aca-004434	Anolis carolinensis	64.90	0.00e+00	883.00
IUUC-Ame-010986	Astyanax mexicanus	71.03	0.00e+00	928.00
IUUC-Bta-012774	Bos taurus	62.39	0.00e+00	857.00
IUUC-Cja-019619	Callithrix jacchus	61.35	0.00e+00	842.00
IUUC-Cfa-020957	Canis familiaris	60.54	0.00e+00	853.00
IUUC-Csa-023177	Chlorocebus sabaeus	61.98	0.00e+00	843.00
IUUC-Cho-024877	Choloepus hoffmanni	58.91	1.00e-151	530.00
IUUC-Csv-025814	Ciona savignyi	42.74	2.00e-142	499.00
IUUC-Dre-027878	Danio rerio	76.85	0.00e+00	647.00
IUUC-Dno-029832	Dasypus novemcinctus	60.97	0.00e+00	844.00
IUUC-Ete-032627	Echinops telfairi	60.68	0.00e+00	835.00
IUUC-Eca-033863	Equus caballus	61.25	0.00e+00	829.00
IUUC-Eeu-035225	Erinaceus europaeus	58.76	0.00e+00	778.00
IUUC-Fca-036288	Felis catus	60.83	0.00e+00	838.00
IUUC-Fal-037207	Ficedula albicollis	63.99	0.00e+00	864.00
IUUC-Gga-040457	Gallus gallus	65.67	0.00e+00	884.00
IUUC-Ggo-044926	Gorilla gorilla	62.07	0.00e+00	850.00
IUUC-Hsa-046079	Homo sapiens	61.78	0.00e+00	847.00
IUUC-Itr-048737	Ictidomys tridecemlineatus	61.44	0.00e+00	842.00
IUUC-Lch-050260	Latimeria chalumnae	63.66	0.00e+00	857.00
IUUC-Loc-051981	Lepisosteus oculatus	71.52	3.00e-180	624.00
IUUC-Laf-054491	Loxodonta africana	61.73	0.00e+00	834.00
IUUC-Mcc-055694	Macaca mulatta	62.12	0.00e+00	844.00
IUUC-Mga-059523	Meleagris gallopavo	65.12	0.00e+00	887.00
IUUC-Mmr-060885	Microcebus murinus	62.21	0.00e+00	864.00
IUUC-Mdo-063018	Monodelphis domestica	64.91	0.00e+00	878.00
IUUC-Mpu-066207	Mustela putorius furo	61.31	0.00e+00	852.00
IUUC-Mlu-066929	Myotis lucifugus	60.18	0.00e+00	808.00
IUUC-Nle-069486	Nomascus leucogenys	60.03	0.00e+00	769.00
IUUC-Opr-070375	Ochotona princeps	57.84	0.00e+00	780.00
IUUC-Ont-071637	Oreochromis niloticus	79.78	0.00e+00	1060.00
IUUC-Oan-073030	Ornithorhynchus anatinus	63.42	0.00e+00	717.00
IUUC-Ocu-074836	Oryctolagus cuniculus	60.55	0.00e+00	818.00
IUUC-Oga-088367	Otolemur garnettii	62.21	0.00e+00	847.00
IUUC-Oar-089953	Ovis aries	62.54	0.00e+00	862.00
IUUC-Ptr-090980	Pan troglodytes	61.93	0.00e+00	850.00
IUUC-Pan-092748	Papio anubis	62.21	0.00e+00	845.00
IUUC-Pma-094155	Petromyzon marinus	58.62	4.00e-82	297.00
IUUC-Pfo-096860	Poecilia formosa	75.14	0.00e+00	1005.00
IUUC-Pab-098514	Pongo abelii	62.12	0.00e+00	852.00
IUUC-Pca-100449	Procavia capensis	59.14	0.00e+00	772.00
IUUC-Pva-102984	Pteropus vampyrus	61.58	0.00e+00	848.00
IUUC-Rno-106019	Rattus norvegicus	58.06	0.00e+00	772.00
IUUC-Sha-106965	Sarcophilus harrisii	64.77	0.00e+00	881.00
IUUC-Ssc-115299	Sus scrofa	61.58	0.00e+00	841.00
IUUC-Tgu-117160	Taeniopygia guttata	65.31	0.00e+00	881.00
IUUC-Tru-118156	Takifugu rubripes	83.47	0.00e+00	1097.00
IUUC-Tbe-128084	Tupaia belangeri	59.11	0.00e+00	798.00
IUUC-Ttr-128928	Tursiops truncatus	62.10	0.00e+00	852.00
IUUC-Vpa-130706	Vicugna pacos	62.16	0.00e+00	845.00
IUUC-Xtr-132061	Xenopus tropicalis	64.98	0.00e+00	840.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence