iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000037463.14	ENSMUST00000039998.10	ENSMUSP00000038432.4
ENSMUSG00000037463.14	ENSMUST00000108281.7	ENSMUSP00000103916.1
ENSMUSG00000037463.14	ENSMUST00000127368.1	ENSMUSP00000146553.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	1.00e-05	26.8	10	64

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 91   tptpeegpdag.lldrlpeeilveilklldkee.llraarvcrrwqelasqkalw 143
            ptpe +p++   l+rlp e+l+ +l+++++++ l++++rvcr w+ l + +alw
   Q: 10   VPTPEPDPQEVlDLSRLPPELLLLVLSHVPPRTlLMHCRRVCRAWRALVDGQALW 64
           588888887651579**************8888799**********999889988 PP

Organism

Mus musculus

Functional Description
(View)

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind complex-type oligosaccharides.

Protein Sequence
(Fasta)

MGAWISRTRV PTPEPDPQEV LDLSRLPPEL LLLVLSHVPP RTLLMHCRRV CRAWRALVDG 60
QALWLLLLAR DHSAAGRALL TLARRCLPPA HEDTPCPLGQ FCALRPLGRN LISNPCGQEG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGATTTAGGG TCACTCCAAG TGTTGGATTG GTTGCTGAAC CGCTAGGACT GTGCCAGAGC 60
CCTGGCCTAA TCTGTGTCCT CAGGTGGATT CCTAAACTGT CCACCAGTCC TAAGCCGGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR007397--F-box-assoc_dom
IPR001810--F-box_dom
IPR008979--Galactose-bd-like

PROSITE

PS51114--FBA
PS50181--FBOX

Pfam

PF00646--F-box
PF04300--FBA

SMART

SM01198--FBA
SM00256--FBOX

Gene Ontology

GO:0019005--C:SCF ubiquitin ligase complex
GO:0001948--F:glycoprotein binding
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

mmu:233040

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cja-019871	Callithrix jacchus	78.84	4.00e-113	400.00
IUUC-Cfa-020053	Canis familiaris	77.97	2.00e-108	385.00
IUUC-Csa-023100	Chlorocebus sabaeus	81.43	1.00e-113	402.00
IUUC-Ggo-045230	Gorilla gorilla	80.17	5.00e-111	393.00
IUUC-Hsa-046246	Homo sapiens	80.17	5.00e-111	393.00
IUUC-Itr-048188	Ictidomys tridecemlineatus	79.51	4.00e-112	397.00
IUUC-Mcc-054973	Macaca mulatta	78.90	8.00e-108	382.00
IUUC-Mdo-062210	Monodelphis domestica	55.93	9.00e-76	276.00
IUUC-Mpu-066761	Mustela putorius furo	76.53	1.00e-96	345.00
IUUC-Ocu-074332	Oryctolagus cuniculus	78.89	4.00e-86	310.00
IUUC-Oga-088717	Otolemur garnettii	68.75	8.00e-93	333.00
IUUC-Oar-089830	Ovis aries	47.29	5.00e-59	221.00
IUUC-Pab-097750	Pongo abelii	80.08	5.00e-112	397.00
IUUC-Rno-104897	Rattus norvegicus	82.63	2.00e-80	291.00
IUUC-Sha-106875	Sarcophilus harrisii	48.75	4.00e-64	238.00
IUUC-Ssc-115329	Sus scrofa	49.81	3.00e-62	231.00
IUUC-Tbe-128058	Tupaia belangeri	75.32	2.00e-70	257.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence