iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000001434.3	ENSXETT00000003026.3	ENSXETP00000003026.3
ENSXETG00000001434.3	ENSXETT00000018278.3	ENSXETP00000018278.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	56.63	2.00e-118	424.00	IUUC-Hsa-046376
E3 activity/RING/RING	49.61	3.00e-93	340.00	IUUC-Mmu-063207
E3 activity/RING/RING	51.57	9.00e-105	377.00	IUUC-Rno-105641

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MAEGEGCSQW RQPCNMNLTS TTNCLENSHI MASDQEKLVK PTPLLLSLLK SAGAQKETFT 60
MKEVIYHLGQ YIMAKQLYDE KQQHIVHCSN DPLGELFGVQ EFSVKEPRRL YAMISRNLVS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAACACGCAG GCATGCGAAA TGGCGCTGCG CTGCCGCTAT TGTGATATAT CCCGTAGTTA 60
ACCTTAAATT CGATGAAGTA AGATAAAACG GCTGGAAGAG ATGGCGGAGG GAGAGGGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome

Interpro

IPR028340--Mdm2
IPR015459--MDM2_E3_ligase
IPR016495--p53_neg-reg_MDM_2/4
IPR003121--SWIB_MDM2_domain
IPR001876--Znf_RanBP2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
PS50089--ZF_RING_2

Pfam

PF02201--SWIB
PF00641--zf-RanBP

Gene Ontology

GO:0005634--C:nucleus
GO:0008270--F:zinc ion binding
GO:0043066--P:negative regulation of apoptotic process
GO:0071157--P:negative regulation of cell cycle arrest
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0016567--P:protein ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002039	Ailuropoda melanoleuca	56.66	2.00e-129	455.00
IUUC-Apl-003193	Anas platyrhynchos	55.38	6.00e-132	464.00
IUUC-Aca-004305	Anolis carolinensis	56.16	1.00e-107	383.00
IUUC-Ame-010675	Astyanax mexicanus	46.33	2.00e-94	339.00
IUUC-Bta-013270	Bos taurus	55.98	3.00e-128	451.00
IUUC-Cja-019744	Callithrix jacchus	55.67	1.00e-126	446.00
IUUC-Cfa-020807	Canis familiaris	53.31	2.00e-114	405.00
IUUC-Cpo-022182	Cavia porcellus	52.87	3.00e-121	428.00
IUUC-Csa-023541	Chlorocebus sabaeus	56.37	2.00e-125	442.00
IUUC-Cin-025448	Ciona intestinalis	26.87	1.00e-18	86.30
IUUC-Csv-026151	Ciona savignyi	32.56	1.00e-12	66.60
IUUC-Dre-028419	Danio rerio	48.34	9.00e-55	207.00
IUUC-Dno-028950	Dasypus novemcinctus	54.09	3.00e-123	434.00
IUUC-Dor-031048	Dipodomys ordii	61.05	1.00e-65	243.00
IUUC-Ete-032264	Echinops telfairi	44.83	2.00e-89	323.00
IUUC-Eca-033301	Equus caballus	53.70	5.00e-124	437.00
IUUC-Eeu-035005	Erinaceus europaeus	50.10	3.00e-103	368.00
IUUC-Fca-035454	Felis catus	54.89	6.00e-124	437.00
IUUC-Fal-036720	Ficedula albicollis	53.31	6.00e-49	187.00
IUUC-Gmo-039296	Gadus morhua	44.71	8.00e-48	183.00
IUUC-Gga-040251	Gallus gallus	57.52	4.00e-132	464.00
IUUC-Gac-041528	Gasterosteus aculeatus	45.50	1.00e-40	160.00
IUUC-Ggo-044948	Gorilla gorilla	54.09	4.00e-115	408.00
IUUC-Hsa-046376	Homo sapiens	56.63	1.00e-127	449.00
IUUC-Itr-048328	Ictidomys tridecemlineatus	53.95	8.00e-121	427.00
IUUC-Lch-050037	Latimeria chalumnae	59.68	2.00e-115	409.00
IUUC-Loc-051837	Lepisosteus oculatus	51.59	4.00e-119	421.00
IUUC-Laf-053483	Loxodonta africana	52.59	1.00e-119	423.00
IUUC-Mcc-055294	Macaca mulatta	56.44	3.00e-127	448.00
IUUC-Mga-060007	Meleagris gallopavo	56.24	6.00e-126	444.00
IUUC-Mmr-060673	Microcebus murinus	55.78	2.00e-136	478.00
IUUC-Mdo-063057	Monodelphis domestica	58.27	2.00e-138	485.00
IUUC-Mmu-063207	Mus musculus	48.92	5.00e-98	351.00
IUUC-Mpu-065836	Mustela putorius furo	54.91	2.00e-129	455.00
IUUC-Mlu-068193	Myotis lucifugus	53.71	5.00e-121	427.00
IUUC-Nle-069927	Nomascus leucogenys	56.63	8.00e-128	450.00
IUUC-Opr-070590	Ochotona princeps	52.78	8.00e-118	417.00
IUUC-Ont-071984	Oreochromis niloticus	45.31	2.00e-53	202.00
IUUC-Oan-072744	Ornithorhynchus anatinus	56.02	6.00e-122	430.00
IUUC-Ocu-074071	Oryctolagus cuniculus	55.53	1.00e-123	437.00
IUUC-Ola-087329	Oryzias latipes	43.67	1.00e-53	203.00
IUUC-Oga-088135	Otolemur garnettii	50.99	3.00e-118	418.00
IUUC-Oar-089726	Ovis aries	56.72	1.00e-132	466.00
IUUC-Ptr-091399	Pan troglodytes	56.63	1.00e-127	449.00
IUUC-Pan-092720	Papio anubis	56.44	3.00e-127	448.00
IUUC-Psi-093591	Pelodiscus sinensis	51.61	2.00e-103	369.00
IUUC-Pma-094500	Petromyzon marinus	36.71	1.00e-29	122.00
IUUC-Pfo-096316	Poecilia formosa	42.68	1.00e-55	210.00
IUUC-Pab-097696	Pongo abelii	56.83	3.00e-126	444.00
IUUC-Pca-100974	Procavia capensis	54.04	3.00e-125	441.00
IUUC-Pva-102488	Pteropus vampyrus	53.16	3.00e-109	388.00
IUUC-Rno-105641	Rattus norvegicus	52.79	5.00e-110	391.00
IUUC-Sha-107314	Sarcophilus harrisii	57.80	1.00e-140	493.00
IUUC-Sar-112938	Sorex araneus	53.78	1.00e-123	436.00
IUUC-Ssc-115495	Sus scrofa	54.38	2.00e-124	439.00
IUUC-Tgu-116623	Taeniopygia guttata	55.56	1.00e-123	436.00
IUUC-Tru-117820	Takifugu rubripes	46.63	8.00e-56	211.00
IUUC-Tbe-127816	Tupaia belangeri	60.19	5.00e-73	268.00
IUUC-Ttr-129194	Tursiops truncatus	52.29	3.00e-78	285.00
IUUC-Vpa-130326	Vicugna pacos	52.09	1.00e-115	409.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence