iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062195

UUCD1 version

UUC-MoD-00931

Ensembl Protein ID

ENSMODP00000037578.1

UniProt Accession

F7A2R7; F7A2R7_MONDO

Protein Name

Uncharacterized protein

Gene Name

HERC3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000019229.3	ENSMODT00000039176.2	ENSMODP00000037578.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.60e-95	319.3	727	1050

Active Site

Position(s)	Description	Evidence
1019	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           dlkk l+v f gEe++d+gGvt+ef+ ll+kel np +g+f+y ++++  ++ +         + ++F+++G+++g+a+++  ++dl
   Q: 727  DLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFV-----EHNWFHLIGIICGLAIYNFTVVDL 808
           899******************************************9999999776554.....579********************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll++k  ledl+e+ p+  +sl++++++  +d+ee  ++l+f++  e++g ++e++L+pgG+++ V ++N++e+v+++
   Q: 809  HFPLALYKKLLNVKPGLEDLKELSPTEGRSLQQLLDYPGEDVEEV-FCLNFTICRESYGVVEEKKLIPGGDKMTVQKDNRQEFVDAY 894
           *************************************99999998.***************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y ++ +++e ++af++Gf +v+  ++l+lF+++el+ +i G++++++e+l++ t ykg+y++++p++++Fwe+++ef  e++k+f
   Q: 895  VNYVFHLSVHEWYAAFSSGFLKVCGGKVLELFQPSELRAMIVGNSNYNWEELEESTIYKGDYSPTHPTVKMFWETFHEFPLEKKKKF 981
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G+ +l+   ++i+   + ++ lP ++TC+n+L+LP+Ysskeil+ +L+ Ai++ +gF+l
   Q: 982  LLFLTGSDRIPIYGMSSLR---IIIQStTSGEEYLPVAHTCYNLLDLPKYSSKEILNIRLTQAIDHYEGFSL 1050
           *******************...7888857778**************************************97 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MLCWGYWSLG HPGGISSNLQ GIVTEPQAYG FISDRSIKEV ACGGNHSIFL LEDGEVYTCG 60
LNTKGQLGHE REGNKPEQIG ALADQHIIHV ACGESHSLAL SDQGQLFSWG AGSDGQLGHT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGGAAAC TGAGGCCCAC AGAAGTCTTG AATTACTCAC AGAAGTGAGG GGGACTTGTC 60
CAAGGTCATG CAACTAGTAA ATGGCAAAAT CAGGATTTGA AATTAGGTCC TCTGAGTTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

mdo:100015909

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001673	Ailuropoda melanoleuca	91.44	0.00e+00	1962.00
IUUC-Apl-003535	Anas platyrhynchos	89.63	0.00e+00	1913.00
IUUC-Aca-005223	Anolis carolinensis	87.63	0.00e+00	1871.00
IUUC-Ame-010816	Astyanax mexicanus	65.71	0.00e+00	1173.00
IUUC-Bta-013373	Bos taurus	91.53	0.00e+00	1964.00
IUUC-Cel-018150	Caenorhabditis elegans	34.13	1.00e-153	537.00
IUUC-Cja-019609	Callithrix jacchus	91.91	0.00e+00	1961.00
IUUC-Cfa-021071	Canis familiaris	91.25	0.00e+00	1953.00
IUUC-Cpo-021548	Cavia porcellus	90.77	0.00e+00	1942.00
IUUC-Csa-023987	Chlorocebus sabaeus	91.82	0.00e+00	1961.00
IUUC-Cho-024325	Choloepus hoffmanni	92.04	0.00e+00	1135.00
IUUC-Dre-027472	Danio rerio	66.57	0.00e+00	1403.00
IUUC-Dno-029241	Dasypus novemcinctus	90.69	0.00e+00	1937.00
IUUC-Dor-030672	Dipodomys ordii	85.11	0.00e+00	1050.00
IUUC-Dme-032103	Drosophila melanogaster	44.48	0.00e+00	854.00
IUUC-Ete-032642	Echinops telfairi	86.30	0.00e+00	1781.00
IUUC-Eca-033646	Equus caballus	91.44	0.00e+00	1954.00
IUUC-Eeu-035098	Erinaceus europaeus	78.93	0.00e+00	1286.00
IUUC-Fal-036952	Ficedula albicollis	89.82	0.00e+00	1912.00
IUUC-Gmo-039297	Gadus morhua	65.30	0.00e+00	1335.00
IUUC-Gga-040591	Gallus gallus	88.59	0.00e+00	1891.00
IUUC-Gac-041741	Gasterosteus aculeatus	65.81	0.00e+00	1394.00
IUUC-Gma-043616	Glycine max	37.46	1.00e-52	200.00
IUUC-Ggo-044769	Gorilla gorilla	91.63	0.00e+00	1953.00
IUUC-Hsa-046066	Homo sapiens	91.72	0.00e+00	1957.00
IUUC-Itr-048311	Ictidomys tridecemlineatus	91.44	0.00e+00	1950.00
IUUC-Lch-050301	Latimeria chalumnae	74.12	0.00e+00	1632.00
IUUC-Loc-052803	Lepisosteus oculatus	67.31	0.00e+00	1457.00
IUUC-Laf-053364	Loxodonta africana	91.72	0.00e+00	1961.00
IUUC-Mcc-054930	Macaca mulatta	91.72	0.00e+00	1960.00
IUUC-Meu-056274	Macropus eugenii	84.22	0.00e+00	926.00
IUUC-Mtr-058277	Medicago truncatula	37.25	4.00e-54	205.00
IUUC-Mga-059563	Meleagris gallopavo	89.25	0.00e+00	1906.00
IUUC-Mmr-060792	Microcebus murinus	90.01	0.00e+00	1909.00
IUUC-Mmu-063855	Mus musculus	89.15	0.00e+00	1920.00
IUUC-Mpu-066308	Mustela putorius furo	91.72	0.00e+00	1961.00
IUUC-Mlu-066927	Myotis lucifugus	91.15	0.00e+00	1948.00
IUUC-Nle-070090	Nomascus leucogenys	91.91	0.00e+00	1963.00
IUUC-Opr-070891	Ochotona princeps	79.92	0.00e+00	1655.00
IUUC-Ont-072201	Oreochromis niloticus	65.00	0.00e+00	1363.00
IUUC-Ocu-074770	Oryctolagus cuniculus	90.96	0.00e+00	1944.00
IUUC-Ola-086550	Oryzias latipes	65.31	0.00e+00	1391.00
IUUC-Olu-087836	Ostreococcus lucimarinus	33.93	2.00e-43	169.00
IUUC-Oga-088831	Otolemur garnettii	91.34	0.00e+00	1947.00
IUUC-Oar-090449	Ovis aries	91.44	0.00e+00	1957.00
IUUC-Pan-092135	Papio anubis	91.73	0.00e+00	1956.00
IUUC-Psi-093832	Pelodiscus sinensis	87.64	0.00e+00	1905.00
IUUC-Ppa-095354	Physcomitrella patens	33.08	5.00e-140	492.00
IUUC-Pfo-097268	Poecilia formosa	65.78	0.00e+00	1394.00
IUUC-Pab-098249	Pongo abelii	91.53	0.00e+00	1957.00
IUUC-Pca-100855	Procavia capensis	87.31	0.00e+00	1333.00
IUUC-Pva-102506	Pteropus vampyrus	83.27	0.00e+00	1713.00
IUUC-Rno-105242	Rattus norvegicus	89.34	0.00e+00	1963.00
IUUC-Sha-107186	Sarcophilus harrisii	96.91	0.00e+00	1298.00
IUUC-Sar-113612	Sorex araneus	91.56	0.00e+00	711.00
IUUC-Ssc-115473	Sus scrofa	90.49	0.00e+00	1938.00
IUUC-Tgu-116974	Taeniopygia guttata	89.92	0.00e+00	1890.00
IUUC-Tru-118077	Takifugu rubripes	64.28	0.00e+00	1326.00
IUUC-Tsy-119619	Tarsius syrichta	80.78	0.00e+00	1730.00
IUUC-Tni-120807	Tetraodon nigroviridis	64.25	0.00e+00	1348.00
IUUC-Tbe-127640	Tupaia belangeri	87.54	0.00e+00	1822.00
IUUC-Ttr-129172	Tursiops truncatus	90.77	0.00e+00	1940.00
IUUC-Vpa-130442	Vicugna pacos	76.11	0.00e+00	1572.00
IUUC-Xtr-132194	Xenopus tropicalis	72.99	0.00e+00	1452.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence