iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aml-002187

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Katanin p80 WD40 repeat-containing subunit B1; p80 katanin

Genbank Nucleotide ID

ACTA01160785

Gene Name

KATNB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000017110.1	ENSAMET00000018844.1	ENSAMEP00000018111.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.70e-45	149.4	145	180
UBD/Beta-Prp	1.70e-59	201.5	15	259

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           gH+  v+cl+f +d + l+s++dD+t+k+WDl+ g+
   Q: 145  GHSQAVRCLRFsPDgKWLASAADDHTVKLWDLTAGK 180
           8***********999*****************9997 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkg 92
           ++ +h ++v + v  + +++llatg++d ++ +w++ +++++ sl gh+++v +v+++  ++++v gs+ + i+vwdl++ k+++tl g
   Q: 15   EIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMG 103
           67788888999888899************************************************************************ PP
   S: 93   hedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtd 181
           h+++++sl+f+p+g++++sGs+d  i++wd++ + c+    +gh+++v+c++++pdg+ l+s+++D tv+lWdl  gk++ ++ g ht+
   Q: 104  HKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVF-RYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPG-HTG 190
           *************************************9.9********************************************9.*** PP
   S: 182  svyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdl 251
           +v+ ++f++n   l+sg+ d+t+++wdl++ ++v   +g   +v+sv f p++  l+sg +D s+r++  
   Q: 191  PVNVVEFHPNEYLLASGGSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVYGW 259
           ***********************************************************765.5666543 PP

Organism

Ailuropoda melanoleuca

Functional Description
(View)

Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.

Protein Sequence
(Fasta)

MATPVVTKTA WKLQEIVAHA SNVSSLVLGK ASGRLLATGG DDCRVNLWSI NKPNCIMSLT 60
GHTSPVESVR LNTPEELIVA GSQSGSIRVW DLEAAKILRT LMGHKANICS LDFHPYGEFV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCACCC CTGTGGTCAC CAAGACGGCC TGGAAATTAC GTGAGTGGTT TTCTTTCTTT 60
TCCTTTCTCA CCCCATTTAT CTTGTTAGCT GCTTGTTGCT GGATGGCCTG AACCCTTGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR026962--Katanin_bsu1
IPR028021--Katanin_C-terminal
IPR002469--Peptidase_S9B_N
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF13925--Katanin_con80
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030424--C:axon
GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0008352--C:katanin complex
GO:0005874--C:microtubule
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0000922--C:spindle pole
GO:0008568--F:microtubule-severing ATPase activity
GO:0051301--P:cell division
GO:0051013--P:microtubule severing
GO:0007079--P:mitotic chromosome movement towards spindle pole
GO:0007026--P:negative regulation of microtubule depolymerization
GO:0031117--P:positive regulation of microtubule depolymerization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000954	Aegilops tauschii	47.51	2.00e-83	304.00
IUUC-Atr-002899	Amborella trichopoda	53.42	1.00e-99	357.00
IUUC-Apl-003305	Anas platyrhynchos	76.27	0.00e+00	996.00
IUUC-Aca-004635	Anolis carolinensis	75.29	0.00e+00	930.00
IUUC-Aly-005711	Arabidopsis lyrata	50.83	1.00e-98	354.00
IUUC-Ath-007606	Arabidopsis thaliana	50.83	2.00e-98	353.00
IUUC-Ame-010870	Astyanax mexicanus	55.09	2.00e-97	348.00
IUUC-Bta-012527	Bos taurus	90.09	0.00e+00	1164.00
IUUC-Bdi-014652	Brachypodium distachyon	52.84	8.00e-101	361.00
IUUC-Bol-015242	Brassica oleracea	49.83	8.00e-97	348.00
IUUC-Bra-017390	Brassica rapa	50.17	3.00e-97	349.00
IUUC-Cja-019706	Callithrix jacchus	88.22	0.00e+00	1051.00
IUUC-Cfa-020139	Canis familiaris	75.38	0.00e+00	740.00
IUUC-Cpo-021710	Cavia porcellus	87.79	0.00e+00	1125.00
IUUC-Cre-022746	Chlamydomonas reinhardtii	40.13	2.00e-66	247.00
IUUC-Csa-023546	Chlorocebus sabaeus	89.22	0.00e+00	1018.00
IUUC-Cin-025156	Ciona intestinalis	39.48	3.00e-150	525.00
IUUC-Csv-025962	Ciona savignyi	48.64	4.00e-86	310.00
IUUC-Dre-028215	Danio rerio	61.17	0.00e+00	826.00
IUUC-Dno-029314	Dasypus novemcinctus	88.07	0.00e+00	1081.00
IUUC-Dor-030482	Dipodomys ordii	88.07	0.00e+00	1164.00
IUUC-Dme-032188	Drosophila melanogaster	40.78	7.00e-57	215.00
IUUC-Eca-034143	Equus caballus	88.65	0.00e+00	1151.00
IUUC-Fca-035924	Felis catus	90.37	0.00e+00	1134.00
IUUC-Fal-037387	Ficedula albicollis	73.74	0.00e+00	957.00
IUUC-Gmo-038692	Gadus morhua	62.84	5.00e-147	514.00
IUUC-Gga-040597	Gallus gallus	73.42	0.00e+00	1003.00
IUUC-Gac-042004	Gasterosteus aculeatus	64.01	1.00e-157	549.00
IUUC-Gma-044134	Glycine max	52.16	2.00e-98	353.00
IUUC-Ggo-044761	Gorilla gorilla	89.66	0.00e+00	1059.00
IUUC-Hsa-045698	Homo sapiens	89.66	0.00e+00	1085.00
IUUC-Hvu-047649	Hordeum vulgare	52.60	6.00e-101	362.00
IUUC-Itr-048697	Ictidomys tridecemlineatus	88.22	0.00e+00	1113.00
IUUC-Lch-049674	Latimeria chalumnae	70.14	0.00e+00	632.00
IUUC-Lpe-051554	Leersia perrieri	53.85	3.00e-103	369.00
IUUC-Loc-052623	Lepisosteus oculatus	65.73	0.00e+00	880.00
IUUC-Laf-054587	Loxodonta africana	89.51	0.00e+00	1140.00
IUUC-Mcc-055851	Macaca mulatta	89.51	0.00e+00	1059.00
IUUC-Meu-056704	Macropus eugenii	84.79	0.00e+00	1145.00
IUUC-Mtr-058053	Medicago truncatula	51.83	1.00e-101	364.00
IUUC-Mga-059608	Meleagris gallopavo	73.49	0.00e+00	996.00
IUUC-Mmr-061154	Microcebus murinus	88.51	0.00e+00	1093.00
IUUC-Mdo-062365	Monodelphis domestica	80.92	0.00e+00	1077.00
IUUC-Mmu-063754	Mus musculus	87.41	0.00e+00	1105.00
IUUC-Mac-064667	Musa acuminata	51.36	8.00e-98	350.00
IUUC-Mpu-066245	Mustela putorius furo	96.50	0.00e+00	778.00
IUUC-Mlu-067692	Myotis lucifugus	88.97	0.00e+00	1113.00
IUUC-Nle-070051	Nomascus leucogenys	87.73	0.00e+00	1048.00
IUUC-Opr-070855	Ochotona princeps	88.36	0.00e+00	1126.00
IUUC-Ont-071883	Oreochromis niloticus	57.92	0.00e+00	796.00
IUUC-Oan-073293	Ornithorhynchus anatinus	83.46	0.00e+00	993.00
IUUC-Ocu-074644	Oryctolagus cuniculus	89.37	0.00e+00	1143.00
IUUC-Oba-075448	Oryza barthii	54.18	1.00e-103	371.00
IUUC-Obr-076385	Oryza brachyantha	53.18	1.00e-102	367.00
IUUC-Ogl-077427	Oryza glaberrima	54.18	5.00e-104	372.00
IUUC-Ogu-079022	Oryza glumaepatula	48.24	6.00e-95	342.00
IUUC-Oin-079811	Oryza indica	51.77	8.00e-101	361.00
IUUC-Olo-080245	Oryza longistaminata	51.77	8.00e-101	361.00
IUUC-Ome-081239	Oryza meridionalis	53.58	2.00e-100	360.00
IUUC-Oni-082640	Oryza nivara	54.18	1.00e-103	371.00
IUUC-Opu-083748	Oryza punctata	50.61	1.00e-103	370.00
IUUC-Oru-084609	Oryza rufipogon	54.18	1.00e-103	371.00
IUUC-Osa-086267	Oryza sativa	48.24	5.00e-95	342.00
IUUC-Ola-087483	Oryzias latipes	53.01	8.00e-177	613.00
IUUC-Oga-087964	Otolemur garnettii	88.07	0.00e+00	1141.00
IUUC-Oar-089483	Ovis aries	89.08	0.00e+00	1131.00
IUUC-Ptr-091387	Pan troglodytes	89.51	0.00e+00	1082.00
IUUC-Pan-092623	Papio anubis	89.51	0.00e+00	1059.00
IUUC-Psi-093830	Pelodiscus sinensis	76.29	0.00e+00	1013.00
IUUC-Ppa-095379	Physcomitrella patens	49.54	1.00e-94	341.00
IUUC-Pfo-096755	Poecilia formosa	54.38	0.00e+00	767.00
IUUC-Pab-097564	Pongo abelii	87.66	0.00e+00	929.00
IUUC-Pop-099149	Populus trichocarpa	51.83	2.00e-101	363.00
IUUC-Pca-100357	Procavia capensis	99.05	3.00e-125	442.00
IUUC-Ppe-101237	Prunus persica	51.83	6.00e-101	362.00
IUUC-Pva-102397	Pteropus vampyrus	85.34	0.00e+00	1048.00
IUUC-Rno-105349	Rattus norvegicus	87.64	0.00e+00	1151.00
IUUC-Smo-109409	Selaginella moellendorffii	48.70	3.00e-98	352.00
IUUC-Sit-110360	Setaria italica	54.18	2.00e-103	370.00
IUUC-Sly-111307	Solanum lycopersicum	51.83	2.00e-96	347.00
IUUC-Stu-112462	Solanum tuberosum	51.37	8.00e-93	334.00
IUUC-Sar-112953	Sorex araneus	81.45	4.00e-104	371.00
IUUC-Sbi-114389	Sorghum bicolor	46.31	2.00e-91	330.00
IUUC-Ssc-115949	Sus scrofa	86.64	0.00e+00	852.00
IUUC-Tgu-117461	Taeniopygia guttata	73.25	0.00e+00	983.00
IUUC-Tru-117865	Takifugu rubripes	56.78	0.00e+00	763.00
IUUC-Tsy-119036	Tarsius syrichta	67.83	6.00e-72	265.00
IUUC-Tni-120903	Tetraodon nigroviridis	62.81	4.00e-144	504.00
IUUC-Tca-121185	Theobroma cacao	50.83	2.00e-98	354.00
IUUC-Tae-125263	Triticum aestivum	52.92	3.00e-101	363.00
IUUC-Tur-126181	Triticum urartu	47.28	3.00e-91	330.00
IUUC-Tbe-127518	Tupaia belangeri	71.93	2.00e-172	598.00
IUUC-Ttr-128172	Tursiops truncatus	88.51	0.00e+00	1093.00
IUUC-Vvi-131489	Vitis vinifera	52.16	2.00e-101	363.00
IUUC-Xtr-132915	Xenopus tropicalis	68.62	0.00e+00	919.00
IUUC-Xma-134133	Xiphophorus maculatus	53.97	0.00e+00	755.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence