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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046325
UUCD1 version UUC-HoS-00716
Ensembl Protein ID ENSP00000369666.2
UniProt Accession Q6PCT2; A8MT10; Q8N789; Q9NT14; FXL19_HUMAN
Genbank Protein ID AAH59173.1; BAC05410.1; CAB70830.1
Protein Name F-box/LRR-repeat protein 19; F-box and leucine-rich repeat protein 19
Genbank Nucleotide ID AC135048; AK098777; AL137589
Gene Name FBXL19; FBL19
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000099364.16 ENST00000565690.5 ENSP00000454344.1
ENSG00000099364.16 ENST00000427128.5 ENSP00000397913.1
ENSG00000099364.16 ENST00000566320.2 ENSP00000455337.2
ENSG00000099364.16 ENST00000565939.1 ENSP00000457199.1
ENSG00000099364.16 ENST00000380310.6 ENSP00000369666.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACRepTar
miRNAMapSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELM
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 22660580; 23871831
Classification
Family E-value Score Start End
E3 activity/RING/PHD 4.20e-12 47.7 86 150
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggede......k....slveCekCrewfHpaClkls.....veeelpnsekwiCpkCrs 53
           +vCl+Cge+g+++      +    sl+eC++C+e++Hp+Clk+      ++ e pn+  w+Cp+C++
   Q: 86   AVCLLCGEAGKEDtvegeeEkfglSLMECTICNEIVHPGCLKMGkaegvINAEIPNC--WECPRCTQ 150
           79**********977766516889*******************99************..******97 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
 Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Protein Sequence
(Fasta)
MGMKVPGKGE SGPSALLTPP MSSSSRGPGA GARRRRTRCR RCRACVRTEC GDCHFCRDMK 60
KFGGPGRMKQ SCLLRQCTAP VLPHTAVCLL CGEAGKEDTV EGEEEKFGLS LMECTICNEI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046325|E3,F-box;E3,PHD|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATCTTGCTTG TAGTCCTCTT TCCTTTTCAC CTTTCCATTG TTCCTGACGA GTAGAAATGG 60
CAGCGGGAAG GCAGCAGATG GACTGCGACT CCCGTCAGGT ACCACACACG CGGAGGGTTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046325|E3,F-box;E3,PHD|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0433--Leucine-rich repeat
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like
IPR006553--Leu-rich_rpt_Cys-con_subtyp
IPR019786--Zinc_finger_PHD-type_CS
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51058--ZF_CXXC
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF00646--F-box
PF16866--PHD_4
PF02008--zf-CXXC
SMART

SM00256--FBOX
SM00367--LRR_CC
SM00249--PHD
Gene Ontology

GO:0005829--C:cytosol
GO:0019005--C:SCF ubiquitin ligase complex
GO:0003677--F:DNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
KEGG hsa:54620
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001680 Ailuropoda melanoleuca 97.99 0.00e+00 917.00
IUUC-Aca-004456 Anolis carolinensis 62.52 0.00e+00 702.00
IUUC-Ame-010726 Astyanax mexicanus 60.00 1.00e-96 348.00
IUUC-Bta-012874 Bos taurus 99.28 0.00e+00 991.00
IUUC-Cja-019918 Callithrix jacchus 98.85 0.00e+00 995.00
IUUC-Cfa-020078 Canis familiaris 99.28 0.00e+00 981.00
IUUC-Cpo-021482 Cavia porcellus 99.54 0.00e+00 972.00
IUUC-Csa-023072 Chlorocebus sabaeus 99.85 0.00e+00 985.00
IUUC-Dno-029532 Dasypus novemcinctus 90.84 0.00e+00 848.00
IUUC-Dor-030932 Dipodomys ordii 98.92 0.00e+00 964.00
IUUC-Eca-033707 Equus caballus 99.69 0.00e+00 979.00
IUUC-Eeu-034841 Erinaceus europaeus 97.47 4.00e-153 534.00
IUUC-Fca-036214 Felis catus 98.70 0.00e+00 980.00
IUUC-Gmo-039631 Gadus morhua 62.18 5.00e-83 301.00
IUUC-Ggo-045362 Gorilla gorilla 99.83 0.00e+00 909.00
IUUC-Itr-048488 Ictidomys tridecemlineatus 99.85 0.00e+00 971.00
IUUC-Lch-049586 Latimeria chalumnae 60.71 1.00e-113 404.00
IUUC-Laf-053994 Loxodonta africana 99.42 0.00e+00 766.00
IUUC-Mcc-054810 Macaca mulatta 100.00 0.00e+00 971.00
IUUC-Meu-056447 Macropus eugenii 99.09 6.00e-145 508.00
IUUC-Mvi-060552 Microbotryum violaceum 29.17 1.00e-03 39.70
IUUC-Mmr-060961 Microcebus murinus 99.14 0.00e+00 996.00
IUUC-Mmu-063602 Mus musculus 97.37 0.00e+00 1004.00
IUUC-Mpu-066470 Mustela putorius furo 99.54 0.00e+00 965.00
IUUC-Mlu-068033 Myotis lucifugus 97.57 0.00e+00 843.00
IUUC-Nle-069352 Nomascus leucogenys 99.57 0.00e+00 981.00
IUUC-Opr-070370 Ochotona princeps 98.98 0.00e+00 899.00
IUUC-Ont-071246 Oreochromis niloticus 61.82 2.00e-92 334.00
IUUC-Ocu-074480 Oryctolagus cuniculus 97.98 0.00e+00 966.00
IUUC-Oba-075194 Oryza barthii 46.43 1.70e-02 32.70
IUUC-Oga-088335 Otolemur garnettii 99.14 0.00e+00 982.00
IUUC-Oar-090135 Ovis aries 82.82 0.00e+00 812.00
IUUC-Ptr-091271 Pan troglodytes 98.82 4.00e-179 620.00
IUUC-Pan-092365 Papio anubis 99.28 0.00e+00 1000.00
IUUC-Pab-097786 Pongo abelii 93.03 0.00e+00 858.00
IUUC-Pca-100857 Procavia capensis 98.77 6.00e-166 577.00
IUUC-Pva-102613 Pteropus vampyrus 99.38 0.00e+00 981.00
IUUC-Rno-106113 Rattus norvegicus 97.83 0.00e+00 1001.00
IUUC-Sha-106914 Sarcophilus harrisii 87.84 0.00e+00 825.00
IUUC-Ssc-115503 Sus scrofa 98.85 0.00e+00 961.00
IUUC-Tru-118079 Takifugu rubripes 64.36 3.00e-92 332.00
IUUC-Tni-120597 Tetraodon nigroviridis 63.64 5.00e-89 322.00
IUUC-Tur-126327 Triticum urartu 35.06 4.00e-04 39.70
IUUC-Tbe-127536 Tupaia belangeri 91.19 0.00e+00 855.00
IUUC-Ttr-128198 Tursiops truncatus 100.00 0.00e+00 949.00
Created Date 25-Jun-2017

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