iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053355

UUCD1 version

UUC-LoA-00539

Ensembl Protein ID

ENSLAFP00000015352.3

UniProt Accession

G3TKJ5; G3TKJ5_LOXAF

Protein Name

Uncharacterized protein

Gene Name

RFFL

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000018323.3	ENSLAFT00000018322.3	ENSLAFP00000015352.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	89.89	2.00e-180	629.00	IUUC-Hsa-045798

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Loxodonta africana

Protein Sequence
(Fasta)

DFIMWATCCN WFCLDGQPED APPPQGARTQ AYSNPGYSSF PSPTGSEPSC KSCGAHFANA 60
ARKQTCLDCK KNFCMTCSSQ VGNGPRLCLL CQRFRATAFQ REELMKMKVK DLRDYLSLHD 120

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Nucleotide Sequence
(Fasta)

GATTTTATAA TGTGGGCAAC CTGCTGCAAC TGGTTCTGTC TGGATGGACA GCCTGAAGAT 60
GCCCCACCCC CCCAGGGAGC CAGGACGCAA GCCTATTCCA ACCCTGGGTA CAGCTCCTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001370--BIR_rpt
IPR003034--SAP_dom
IPR011011--Znf_FYVE_PHD
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0010008--C:endosome membrane
GO:0005886--C:plasma membrane
GO:0002947--C:tumor necrosis factor receptor superfamily complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:2001271--P:negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1901797--P:negative regulation of signal transduction by p53 class mediator
GO:0010804--P:negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001630	Ailuropoda melanoleuca	85.91	2.00e-173	601.00
IUUC-Apl-004124	Anas platyrhynchos	65.67	2.00e-119	422.00
IUUC-Aly-005548	Arabidopsis lyrata	47.06	1.00e-08	55.10
IUUC-Afl-008647	Aspergillus flavus	35.00	2.00e-09	58.90
IUUC-Afu-009000	Aspergillus fumigatus	36.25	1.00e-10	62.40
IUUC-Aor-010131	Aspergillus oryzae	36.25	1.00e-09	59.30
IUUC-Ate-010322	Aspergillus terreus	33.75	5.00e-10	60.50
IUUC-Ame-011616	Astyanax mexicanus	56.79	4.00e-102	364.00
IUUC-Bta-012374	Bos taurus	81.84	4.00e-167	580.00
IUUC-Cja-019780	Callithrix jacchus	87.70	0.00e+00	635.00
IUUC-Cfa-021252	Canis familiaris	88.35	4.00e-177	613.00
IUUC-Cpo-022047	Cavia porcellus	86.99	3.00e-179	620.00
IUUC-Csa-023161	Chlorocebus sabaeus	88.52	0.00e+00	641.00
IUUC-Cho-024316	Choloepus hoffmanni	87.87	5.00e-146	509.00
IUUC-Dre-028596	Danio rerio	55.59	2.00e-105	375.00
IUUC-Dno-029333	Dasypus novemcinctus	89.34	0.00e+00	631.00
IUUC-Ete-033163	Echinops telfairi	81.37	7.00e-159	553.00
IUUC-Eca-033994	Equus caballus	88.08	0.00e+00	635.00
IUUC-Eeu-035162	Erinaceus europaeus	82.78	1.00e-121	429.00
IUUC-Fca-036418	Felis catus	86.99	0.00e+00	643.00
IUUC-Fal-037427	Ficedula albicollis	63.96	2.00e-126	445.00
IUUC-Gga-041053	Gallus gallus	66.39	2.00e-126	445.00
IUUC-Ggo-045436	Gorilla gorilla	89.89	0.00e+00	651.00
IUUC-Hsa-045798	Homo sapiens	89.89	0.00e+00	651.00
IUUC-Itr-048077	Ictidomys tridecemlineatus	88.32	4.00e-179	620.00
IUUC-Lch-050639	Latimeria chalumnae	62.02	6.00e-120	423.00
IUUC-Lma-053223	Leptosphaeria maculans	29.58	6.00e-08	53.90
IUUC-Mcc-055222	Macaca mulatta	88.25	6.00e-179	619.00
IUUC-Meu-056692	Macropus eugenii	77.81	1.00e-154	539.00
IUUC-Mga-059298	Meleagris gallopavo	65.76	7.00e-126	443.00
IUUC-Mmr-061792	Microcebus murinus	85.25	4.00e-173	600.00
IUUC-Mdo-062986	Monodelphis domestica	79.89	4.00e-158	550.00
IUUC-Mmu-063356	Mus musculus	87.26	3.00e-180	624.00
IUUC-Mpu-066273	Mustela putorius furo	88.04	0.00e+00	643.00
IUUC-Mlu-066953	Myotis lucifugus	86.68	2.00e-178	617.00
IUUC-Nle-070075	Nomascus leucogenys	88.89	0.00e+00	654.00
IUUC-Opr-070838	Ochotona princeps	86.07	1.00e-173	602.00
IUUC-Ont-071967	Oreochromis niloticus	71.72	8.00e-53	200.00
IUUC-Ocu-074807	Oryctolagus cuniculus	86.45	0.00e+00	629.00
IUUC-Obr-076159	Oryza brachyantha	41.07	4.00e-08	50.40
IUUC-Ola-086903	Oryzias latipes	68.42	8.00e-54	204.00
IUUC-Oga-088536	Otolemur garnettii	85.25	1.00e-168	585.00
IUUC-Oar-089838	Ovis aries	82.11	1.00e-167	582.00
IUUC-Ptr-090962	Pan troglodytes	89.62	0.00e+00	651.00
IUUC-Pan-092853	Papio anubis	87.70	0.00e+00	636.00
IUUC-Psi-093164	Pelodiscus sinensis	69.84	3.00e-122	431.00
IUUC-Pma-094104	Petromyzon marinus	45.08	7.00e-56	211.00
IUUC-Pno-094968	Phaeosphaeria nodorum	31.08	2.00e-09	59.30
IUUC-Pab-098304	Pongo abelii	89.16	0.00e+00	652.00
IUUC-Pca-100316	Procavia capensis	90.68	5.00e-178	616.00
IUUC-Ppe-101490	Prunus persica	35.71	7.00e-09	55.50
IUUC-Pva-102612	Pteropus vampyrus	74.86	3.00e-144	504.00
IUUC-Rno-105449	Rattus norvegicus	87.16	3.00e-177	613.00
IUUC-Sha-107578	Sarcophilus harrisii	79.08	6.00e-150	523.00
IUUC-Sar-113638	Sorex araneus	82.79	4.00e-165	573.00
IUUC-Ssc-116401	Sus scrofa	86.18	0.00e+00	632.00
IUUC-Tru-118765	Takifugu rubripes	49.05	6.00e-79	287.00
IUUC-Tsy-118850	Tarsius syrichta	83.33	2.00e-140	491.00
IUUC-Tbe-128086	Tupaia belangeri	81.37	2.00e-165	574.00
IUUC-Ttr-128249	Tursiops truncatus	66.39	1.00e-129	455.00
IUUC-Vpa-130816	Vicugna pacos	80.68	6.00e-37	147.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence