iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-010662

Ensembl Protein ID

ENSAMXP00000011673.1

UniProt Accession

W5KVR1; W5KVR1_ASTMX

Genbank Protein ID

ENSAMXP00000011673

Protein Name

Ubiquitin thioesterase

Genbank Nucleotide ID

APWO01085222

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000011362.1	ENSAMXT00000011673.1	ENSAMXP00000011673.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	5.90e-47	159.8	76	266

Active Site

Position(s)	Description	Evidence
83	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
86	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
260		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs..........................................................llgvfdddslsd 32
           +i+kt++DGnC++rA+++s                                                          ll++f+d+s+sd
   Q: 76   YIRKTRPDGNCFYRAFGFShlesllddgkelqkfkavaakskldlvtqgfteftiedfhntfmdlielcekqpalgeLLNSFNDQSVSD 164
           89*************************************************************************************** PP
   S: 33   alveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklk 120
           ++v++Lr+lts ylq+e+ ff++fie+++ +kefcq++vep++k +++ihi+aLaq+L+++i v+++d++e   gg++++++fpe + +
   Q: 165  YVVVYLRLLTSGYLQREHGFFQHFIEGGRSVKEFCQQEVEPMSKeSDHIHIIALAQALNVSILVEYMDRGE---GGTVNHHVFPEGS-E 249
           **********************************************************************9...9************.* PP
   S: 121  kpivLlYrsgHYdaLva 137
           ++i LlYr+gHYd+L++
   Q: 250  PRIFLLYRPGHYDILYK 266
           ***************96 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

MADEQQETSQ GEVEGVNCLA YDEAIMAQQD RIQQEIATTN PLVSDRQELS VLQKEYAEED 60
TIYQLKIKDL HKKYSYIRKT RPDGNCFYRA FGFSHLESLL DDGKELQKFK AVAAKSKLDL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCAAGCCCA TTTGTGCAAG AAAATATAAA TAAATAAATA AATAATAATA AAAATACTGT 60
GAAACCGTCA GAATCTTGAA AAATACCGTG ATATGCATTT TTGGTCATAC CGATCAGACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003323--OTU_dom
IPR030298--OTUB1
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0071108--P:protein K48-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001871	Ailuropoda melanoleuca	81.55	8.00e-130	456.00
IUUC-Apl-003233	Anas platyrhynchos	55.38	6.00e-16	75.10
IUUC-Aca-004648	Anolis carolinensis	81.71	2.00e-122	431.00
IUUC-Aly-005710	Arabidopsis lyrata	43.32	2.00e-53	202.00
IUUC-Afl-008439	Aspergillus flavus	31.46	3.00e-07	48.90
IUUC-Bta-013533	Bos taurus	85.38	1.00e-128	452.00
IUUC-Bol-016100	Brassica oleracea	43.73	1.00e-52	199.00
IUUC-Bra-017705	Brassica rapa	39.58	3.00e-45	175.00
IUUC-Cel-018295	Caenorhabditis elegans	34.18	7.00e-39	154.00
IUUC-Cja-019190	Callithrix jacchus	85.38	4.00e-129	454.00
IUUC-Cfa-020430	Canis familiaris	85.32	2.00e-128	451.00
IUUC-Cpo-022355	Cavia porcellus	85.77	1.00e-129	455.00
IUUC-Csa-023286	Chlorocebus sabaeus	82.44	6.00e-127	446.00
IUUC-Cho-024411	Choloepus hoffmanni	44.78	6.00e-30	123.00
IUUC-Dre-028315	Danio rerio	91.01	5.00e-137	479.00
IUUC-Dno-029165	Dasypus novemcinctus	84.50	7.00e-102	362.00
IUUC-Dor-030943	Dipodomys ordii	85.77	1.00e-129	455.00
IUUC-Dme-031922	Drosophila melanogaster	56.80	2.00e-76	278.00
IUUC-Ete-032296	Echinops telfairi	81.13	4.00e-75	274.00
IUUC-Eca-033695	Equus caballus	84.52	2.00e-127	448.00
IUUC-Fca-036441	Felis catus	85.04	6.00e-129	452.00
IUUC-Gmo-038908	Gadus morhua	90.60	4.00e-145	506.00
IUUC-Ggr-040020	Gaeumannomyces graminis	33.57	1.00e-32	135.00
IUUC-Gga-040460	Gallus gallus	73.68	5.00e-116	410.00
IUUC-Gac-042417	Gasterosteus aculeatus	90.40	6.00e-138	483.00
IUUC-Ggo-044552	Gorilla gorilla	83.02	2.00e-77	281.00
IUUC-Hsa-046766	Homo sapiens	85.38	2.00e-129	454.00
IUUC-Itr-048312	Ictidomys tridecemlineatus	85.77	1.00e-129	455.00
IUUC-Lch-050602	Latimeria chalumnae	77.38	2.00e-115	407.00
IUUC-Laf-053705	Loxodonta africana	85.77	1.00e-129	455.00
IUUC-Mcc-055745	Macaca mulatta	79.70	7.00e-126	443.00
IUUC-Meu-056569	Macropus eugenii	75.89	4.00e-112	397.00
IUUC-Mtr-057712	Medicago truncatula	42.38	1.00e-46	179.00
IUUC-Mvi-060358	Microbotryum violaceum	35.76	4.00e-18	85.10
IUUC-Mmr-061123	Microcebus murinus	86.38	3.00e-107	381.00
IUUC-Mdo-062613	Monodelphis domestica	75.85	9.00e-104	369.00
IUUC-Mmu-063658	Mus musculus	85.77	1.00e-129	455.00
IUUC-Mac-065274	Musa acuminata	37.20	2.00e-37	149.00
IUUC-Mpu-066172	Mustela putorius furo	85.38	2.00e-129	454.00
IUUC-Mlu-066966	Myotis lucifugus	85.10	8.00e-130	456.00
IUUC-Nle-069519	Nomascus leucogenys	81.99	5.00e-78	284.00
IUUC-Ont-071901	Oreochromis niloticus	92.03	2.00e-139	488.00
IUUC-Ola-087331	Oryzias latipes	91.01	6.00e-96	343.00
IUUC-Oga-088064	Otolemur garnettii	85.38	2.00e-129	454.00
IUUC-Oar-089251	Ovis aries	84.98	3.00e-127	447.00
IUUC-Ptr-091430	Pan troglodytes	85.38	6.00e-129	453.00
IUUC-Psi-093823	Pelodiscus sinensis	80.93	2.00e-120	425.00
IUUC-Pma-094366	Petromyzon marinus	70.19	5.00e-100	357.00
IUUC-Pfo-096734	Poecilia formosa	89.24	1.00e-127	448.00
IUUC-Pab-097919	Pongo abelii	85.92	1.00e-105	375.00
IUUC-Pop-099401	Populus trichocarpa	41.24	1.00e-50	192.00
IUUC-Ppe-101977	Prunus persica	42.75	3.00e-51	195.00
IUUC-Pva-102499	Pteropus vampyrus	85.26	4.00e-128	450.00
IUUC-Rno-105233	Rattus norvegicus	85.77	1.00e-129	455.00
IUUC-Sha-107081	Sarcophilus harrisii	84.52	2.00e-127	448.00
IUUC-Sly-111640	Solanum lycopersicum	42.38	2.00e-49	189.00
IUUC-Ssc-116202	Sus scrofa	85.38	2.00e-129	454.00
IUUC-Tru-117664	Takifugu rubripes	88.19	2.00e-143	501.00
IUUC-Tbe-128116	Tupaia belangeri	81.99	4.00e-78	284.00
IUUC-Ttr-128622	Tursiops truncatus	84.98	4.00e-127	446.00
IUUC-Xma-134191	Xiphophorus maculatus	88.84	5.00e-128	450.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence