iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000100379.17	ENST00000402077.7	ENSP00000384391.3
ENSG00000100379.17	ENST00000403888.7	ENSP00000385096.3
ENSG00000100379.17	ENST00000421900.5	ENSP00000409116.1
ENSG00000100379.17	ENST00000456470.1	ENSP00000409638.1
ENSG00000100379.17	ENST00000431531.1	ENSP00000402434.1
ENSG00000100379.17	ENST00000610767.4	ENSP00000480699.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	3.30e-10	41.8	31	99

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaas.SsvFyalf.lmele.esksklmveikdvqpevfrallkFlYtgklde 67
           ++v l+vgg++f +++ +L++   s++++l+   el  ++++++ + i+ ++p++f  +l+Fl++gkl +
   Q: 31   KWVRLNVGGTVFLTTRQTLCREqKSFLSRLCqGEELQsDRDETGAYLID-RDPTYFGPILNFLRHGKLVL 99
           59********************9********54567778999*******.*****************976 PP

Organism

Homo sapiens

Functional Description
(View)

Is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. It acts as a substrate-adapter for CUL3-RING ubiquitin ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of TCHP, a protein involved in ciliogenesis down-regulation (PubMed:25270598). May be involved in endoplasmic reticulum calcium ion homeostasis (PubMed:25983243).

Protein Sequence
(Fasta)

MQTPRPAMRM EAGEAAPPAG AGGRAAGGWG KWVRLNVGGT VFLTTRQTLC REQKSFLSRL 60
CQGEELQSDR DETGAYLIDR DPTYFGPILN FLRHGKLVLD KDMAEEGVLE EAEFYNIGPL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGGATGCAG ACGCCGCGGC CGGCGATGAG GATGGAGGCC GGGGAGGCAG CGCCGCCGGC 60
GGGGGCGGGC GGCCGCGCCG CAGGCGGCTG GGGCAAGTGG GTGCGGCTCA ACGTGGGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0970--Cilium biogenesis/degradation
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-1023--Dystonia
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR003131--T1-type_BTB

Pfam

PF02214--BTB_2

SMART

SM00225--BTB

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005783--C:endoplasmic reticulum
GO:0097602--F:cullin family protein binding
GO:0042802--F:identical protein binding
GO:0032403--F:protein complex binding
GO:0030030--P:cell projection organization
GO:0032469--P:endoplasmic reticulum calcium ion homeostasis
GO:0045724--P:positive regulation of cilium assembly
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051260--P:protein homooligomerization

KEGG

hsa:79734

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002288	Ailuropoda melanoleuca	97.79	2.00e-103	368.00
IUUC-Apl-003510	Anas platyrhynchos	93.37	5.00e-100	356.00
IUUC-Aca-005203	Anolis carolinensis	92.82	9.00e-99	352.00
IUUC-Ame-011568	Astyanax mexicanus	74.05	9.00e-78	283.00
IUUC-Bta-013073	Bos taurus	86.64	5.00e-133	467.00
IUUC-Cja-019224	Callithrix jacchus	90.68	5.00e-128	450.00
IUUC-Cpo-021651	Cavia porcellus	98.34	7.00e-106	375.00
IUUC-Csa-023796	Chlorocebus sabaeus	99.45	3.00e-106	377.00
IUUC-Dre-027381	Danio rerio	78.26	2.00e-78	285.00
IUUC-Dor-030977	Dipodomys ordii	84.67	9.00e-105	373.00
IUUC-Fca-035758	Felis catus	89.27	1.00e-98	352.00
IUUC-Fal-037346	Ficedula albicollis	93.99	9.00e-102	362.00
IUUC-Ggo-044722	Gorilla gorilla	96.56	2.00e-147	514.00
IUUC-Itr-048109	Ictidomys tridecemlineatus	96.15	2.00e-101	362.00
IUUC-Lch-050418	Latimeria chalumnae	79.56	7.00e-78	283.00
IUUC-Laf-054166	Loxodonta africana	94.79	2.00e-103	368.00
IUUC-Mcc-055528	Macaca mulatta	99.07	5.00e-145	506.00
IUUC-Meu-056576	Macropus eugenii	71.33	2.00e-107	382.00
IUUC-Mmr-061106	Microcebus murinus	78.79	8.00e-127	446.00
IUUC-Mdo-062042	Monodelphis domestica	75.17	1.00e-109	389.00
IUUC-Mmu-063745	Mus musculus	95.77	2.00e-107	382.00
IUUC-Mpu-066798	Mustela putorius furo	84.98	2.00e-114	405.00
IUUC-Nle-069056	Nomascus leucogenys	99.66	1.00e-141	495.00
IUUC-Ont-071858	Oreochromis niloticus	79.12	1.00e-77	283.00
IUUC-Oga-087966	Otolemur garnettii	92.41	4.00e-132	464.00
IUUC-Oar-089758	Ovis aries	86.81	4.00e-131	460.00
IUUC-Ptr-091330	Pan troglodytes	92.21	1.00e-130	459.00
IUUC-Pan-092327	Papio anubis	91.75	1.00e-147	515.00
IUUC-Psi-093235	Pelodiscus sinensis	92.27	4.00e-99	353.00
IUUC-Pab-098084	Pongo abelii	99.66	1.00e-141	495.00
IUUC-Pca-100798	Procavia capensis	72.59	9.00e-100	356.00
IUUC-Rno-105754	Rattus norvegicus	97.18	2.00e-110	391.00
IUUC-Ssc-115240	Sus scrofa	98.36	2.00e-107	381.00
IUUC-Tgu-117209	Taeniopygia guttata	93.99	6.00e-102	362.00
IUUC-Tru-118035	Takifugu rubripes	79.67	1.00e-78	285.00
IUUC-Ttr-128632	Tursiops truncatus	79.38	1.00e-106	379.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence