iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066878

Ensembl Protein ID

ENSMPUP00000007076.1

UniProt Accession

M3Y6X4; M3Y6X4_MUSPF

Genbank Protein ID

ENSMPUP00000007076

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01096847

Gene Name

SHARPIN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000007133.1	ENSMPUT00000007194.1	ENSMPUP00000007076.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/ZnF/NZF	7.40e-13	47.8	306	334
ULD/UDP/UBQ/UBQ_Other	5.90e-14	51.7	187	248

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 2    eaqWaCsaCTflNePeavkCemCsrpRgc 30
           ++ W+C++CTf+N+P +++CemCs++++c
   Q: 306  QPSWSCPSCTFINAPGRPGCEMCSTQKPC 334
           578*************************9 PP

ULD/UDP/UBQ/UBQ_Other

   S: 2    qvtvksldgs.eltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiL.eddktLadyglk 62
           qvtv+++ +s + +l+v+p++t+a+L+e++++++g+pp+ qr+++ G++L  + ++La+yg++
   Q: 187  QVTVEDAASSaHVSLQVHPHCTIATLQEQVFSEFGFPPAVQRWVI-GRCLcVPERSLASYGVR 248
           89*******************************************.**************995 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

SLMPIGCGPR SSRPCCQPAF PGAXRLELLG AGPGAVSLEW PLESVCYTVR GPSQHELQPP 60
PGGPGTLSLH FLDPQEAQRW AALVRGATME GQNGSPSQAL GPEMCPVSLP SPPEAPTLQA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCCTGATGC CCATTGGTTG CGGCCCTCGC TCGTCCCGCC CCTGTTGTCA GCCCGCGTTC 60
CCCGGAGCGG CNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome

Interpro

IPR031912--Sharpin_PH
IPR029071--Ubiquitin-rel_dom
IPR001876--Znf_RanBP2

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2

Pfam

PF16764--Sharpin_PH

SMART

SM00547--ZnF_RBZ

Gene Ontology

GO:0005829--C:cytosol
GO:0071797--C:LUBAC complex
GO:0008270--F:zinc ion binding
GO:0030262--P:apoptotic nuclear changes
GO:0031424--P:keratinization
GO:0007005--P:mitochondrion organization
GO:0050728--P:negative regulation of inflammatory response
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0097039--P:protein linear polyubiquitination
GO:2000348--P:regulation of CD40 signaling pathway
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000111	Aegilops tauschii	34.21	7.70e-02	31.20
IUUC-Aml-001223	Ailuropoda melanoleuca	84.73	3.00e-135	474.00
IUUC-Apl-004151	Anas platyrhynchos	70.21	8.00e-19	84.70
IUUC-Ang-009713	Aspergillus niger	30.00	8.80e-02	31.20
IUUC-Bta-012948	Bos taurus	76.19	2.00e-137	481.00
IUUC-Cja-019031	Callithrix jacchus	73.46	4.00e-116	410.00
IUUC-Cfa-020863	Canis familiaris	81.76	2.00e-126	445.00
IUUC-Cpo-022499	Cavia porcellus	69.73	2.00e-107	382.00
IUUC-Csa-023641	Chlorocebus sabaeus	73.26	2.00e-111	395.00
IUUC-Dno-029459	Dasypus novemcinctus	58.78	1.00e-62	233.00
IUUC-Dor-030914	Dipodomys ordii	56.48	6.00e-66	244.00
IUUC-Ete-032940	Echinops telfairi	64.26	1.00e-88	320.00
IUUC-Eca-033537	Equus caballus	82.42	2.00e-127	448.00
IUUC-Eeu-035176	Erinaceus europaeus	64.38	2.00e-62	233.00
IUUC-Fca-035971	Felis catus	84.17	8.00e-142	496.00
IUUC-Gmo-039219	Gadus morhua	37.42	5.00e-44	171.00
IUUC-Gga-040198	Gallus gallus	44.79	3.00e-30	125.00
IUUC-Ggo-044678	Gorilla gorilla	74.03	3.00e-116	411.00
IUUC-Hsa-046578	Homo sapiens	76.19	7.00e-122	430.00
IUUC-Itr-047913	Ictidomys tridecemlineatus	73.91	1.00e-116	412.00
IUUC-Mcc-055686	Macaca mulatta	71.09	3.00e-114	404.00
IUUC-Meu-055912	Macropus eugenii	55.22	3.00e-61	228.00
IUUC-Mmr-060584	Microcebus murinus	70.67	4.00e-124	437.00
IUUC-Mdo-062191	Monodelphis domestica	54.67	3.00e-85	308.00
IUUC-Mmu-063740	Mus musculus	65.36	7.00e-99	353.00
IUUC-Mlu-067878	Myotis lucifugus	79.57	7.00e-119	420.00
IUUC-Nle-069748	Nomascus leucogenys	77.21	1.00e-113	402.00
IUUC-Ont-072270	Oreochromis niloticus	40.06	8.00e-47	181.00
IUUC-Oga-088300	Otolemur garnettii	69.81	5.00e-121	427.00
IUUC-Oar-089549	Ovis aries	77.47	9.00e-137	479.00
IUUC-Ptr-090961	Pan troglodytes	74.83	8.00e-111	393.00
IUUC-Pan-092687	Papio anubis	77.58	6.00e-116	410.00
IUUC-Pfo-096865	Poecilia formosa	34.36	4.00e-37	149.00
IUUC-Pab-097872	Pongo abelii	72.34	2.00e-111	395.00
IUUC-Pca-100363	Procavia capensis	65.74	2.00e-62	233.00
IUUC-Pva-102595	Pteropus vampyrus	80.07	4.00e-110	391.00
IUUC-Rno-105856	Rattus norvegicus	67.46	6.00e-99	353.00
IUUC-Sha-106838	Sarcophilus harrisii	55.90	5.00e-74	271.00
IUUC-Sar-113611	Sorex araneus	60.36	1.00e-25	109.00
IUUC-Ssc-116263	Sus scrofa	72.68	1.00e-133	469.00
IUUC-Tru-118089	Takifugu rubripes	42.86	7.00e-54	204.00
IUUC-Tni-120004	Tetraodon nigroviridis	40.45	5.00e-46	178.00
IUUC-Tbe-127471	Tupaia belangeri	62.76	2.00e-90	325.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence