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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046003
Ensembl Protein ID ENSP00000260643.2
UniProt Accession Q9HCU5; Q53SZ8; Q9UH94; PREB_HUMAN
Genbank Protein ID AAG01692.1; AAF19192.1; AAF74572.1; BAB14385.1; AAX93170.1; EAX00627.1; AAH02765.1; AAH12890.1; AAH16472.1; AAH41032.1
Protein Name Prolactin regulatory element-binding protein; Mammalian guanine nucleotide exchange factor mSec12
Genbank Nucleotide ID AF226684; AF203687; AF227166; AK023064; AC013403; CH471053; BC002765; BC012890; BC016472; BC041032
Gene Name PREB; SEC12
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000138073.13 ENST00000260643.6 ENSP00000260643.2
ENSG00000138073.13 ENST00000444452.5 ENSP00000416103.1
ENSG00000138073.13 ENST00000406567.7 ENSP00000384032.3
ENSG00000138073.13 ENST00000456259.5 ENSP00000397036.1
ENSG00000138073.13 ENST00000430533.1 ENSP00000407036.1
ENSG00000138073.13 ENST00000441451.1 ENSP00000391894.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.00e-08 35.9 160 185
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 9    laf.sd.tllvsGsdDgtikvWDlrt 32
           ++f +d tll++G+ Dg ++vW + +
   Q: 160  VCFnHDnTLLATGGTDGYVRVWKVPS 185
           5688566***************9865 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription.
 Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription.
Protein Sequence
(Fasta)
MGRRRAPELY RAPFPLYALQ VDPSTGLLIA AGGGGAAKTG IKNGVHFLQL ELINGRLSAS 60
LLHSHDTETR ATMNLALAGD ILAAGQDAHC QLLRFQAHQQ QGNKAEKAGS KEQGPRQRKG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046003|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCCTGCGCGG AGGGAGCCGC GAGACAGGTG CGCATGCGCA GTGCGCGTCT GCGAGACCGA 60
CTTGGACGGA GCCGAGCTGA GGCTCGGCTT CCTGCTGATG GTCAGGGTTT TGGCAACTCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046003|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0256--Endoplasmic reticulum
KW-0931--ER-Golgi transport
KW-0472--Membrane
KW-0944--Nitration
KW-0539--Nucleus
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0070971--C:endoplasmic reticulum exit site
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0005096--F:GTPase activator activity
GO:0051020--F:GTPase binding
GO:0005085--F:guanyl-nucleotide exchange factor activity
GO:0005090--F:Sar guanyl-nucleotide exchange factor activity
GO:0048208--P:COPII vesicle coating
GO:0006888--P:ER to Golgi vesicle-mediated transport
GO:0036498--P:IRE1-mediated unfolded protein response
GO:0032527--P:protein exit from endoplasmic reticulum
GO:0009306--P:protein secretion
GO:0003400--P:regulation of COPII vesicle coating
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG hsa:10113
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000155 Aegilops tauschii 22.48 1.00e-08 54.30
IUUC-Aml-001671 Ailuropoda melanoleuca 91.90 0.00e+00 682.00
IUUC-Atr-002477 Amborella trichopoda 25.88 3.00e-11 62.80
IUUC-Ath-007466 Arabidopsis thaliana 27.00 4.00e-12 65.90
IUUC-Ame-010812 Astyanax mexicanus 51.95 5.00e-66 244.00
IUUC-Bta-012386 Bos taurus 92.58 0.00e+00 728.00
IUUC-Bdi-014110 Brachypodium distachyon 27.17 1.00e-19 90.90
IUUC-Bra-017708 Brassica rapa 28.11 5.00e-15 75.50
IUUC-Cel-018480 Caenorhabditis elegans 24.05 1.00e-19 91.30
IUUC-Cja-018998 Callithrix jacchus 95.64 0.00e+00 778.00
IUUC-Cfa-020666 Canis familiaris 92.82 0.00e+00 720.00
IUUC-Cpo-022030 Cavia porcellus 84.05 0.00e+00 649.00
IUUC-Csa-023521 Chlorocebus sabaeus 98.33 0.00e+00 753.00
IUUC-Cin-025431 Ciona intestinalis 31.52 4.00e-47 182.00
IUUC-Cne-027001 Cryptococcus neoformans 26.12 3.00e-07 49.70
IUUC-Dre-027832 Danio rerio 55.76 9.00e-131 460.00
IUUC-Dno-028989 Dasypus novemcinctus 89.95 0.00e+00 734.00
IUUC-Dme-031901 Drosophila melanogaster 31.84 1.00e-49 190.00
IUUC-Ete-032290 Echinops telfairi 90.67 0.00e+00 693.00
IUUC-Eca-033917 Equus caballus 93.30 0.00e+00 731.00
IUUC-Fca-036323 Felis catus 93.30 0.00e+00 734.00
IUUC-Gmo-038693 Gadus morhua 56.98 1.00e-131 462.00
IUUC-Gga-040702 Gallus gallus 66.83 6.00e-143 500.00
IUUC-Gac-042635 Gasterosteus aculeatus 55.15 2.00e-118 419.00
IUUC-Gma-043946 Glycine max 28.21 5.00e-19 89.00
IUUC-Ggo-044648 Gorilla gorilla 98.32 0.00e+00 723.00
IUUC-Itr-048613 Ictidomys tridecemlineatus 92.09 0.00e+00 711.00
IUUC-Lch-049473 Latimeria chalumnae 60.14 1.00e-141 496.00
IUUC-Lpe-051586 Leersia perrieri 26.10 2.00e-18 87.00
IUUC-Loc-052177 Lepisosteus oculatus 60.43 2.00e-141 495.00
IUUC-Laf-054366 Loxodonta africana 93.30 0.00e+00 721.00
IUUC-Mcc-055775 Macaca mulatta 98.09 0.00e+00 752.00
IUUC-Meu-056562 Macropus eugenii 79.43 4.00e-164 570.00
IUUC-Mtr-058661 Medicago truncatula 28.21 2.00e-18 87.00
IUUC-Mvi-060443 Microbotryum violaceum 24.07 1.00e-10 61.20
IUUC-Mmr-061126 Microcebus murinus 94.74 0.00e+00 708.00
IUUC-Mdo-062928 Monodelphis domestica 79.29 3.00e-165 574.00
IUUC-Mmu-064083 Mus musculus 88.73 0.00e+00 642.00
IUUC-Mac-064955 Musa acuminata 27.43 2.00e-16 79.70
IUUC-Mpu-066857 Mustela putorius furo 90.67 0.00e+00 743.00
IUUC-Mlu-067891 Myotis lucifugus 92.82 0.00e+00 709.00
IUUC-Nle-070030 Nomascus leucogenys 96.64 0.00e+00 732.00
IUUC-Opr-070864 Ochotona princeps 91.79 1.00e-133 469.00
IUUC-Ont-072204 Oreochromis niloticus 58.66 2.00e-129 456.00
IUUC-Oan-073643 Ornithorhynchus anatinus 72.73 1.00e-121 429.00
IUUC-Ocu-074217 Oryctolagus cuniculus 90.43 0.00e+00 662.00
IUUC-Oba-075587 Oryza barthii 26.82 1.00e-17 84.00
IUUC-Obr-076826 Oryza brachyantha 25.19 7.00e-19 88.20
IUUC-Ogl-077927 Oryza glaberrima 25.10 3.00e-18 86.70
IUUC-Ogu-078241 Oryza glumaepatula 25.10 3.00e-18 85.90
IUUC-Oin-080217 Oryza indica 25.10 6.00e-18 85.10
IUUC-Olo-081060 Oryza longistaminata 25.00 5.00e-18 85.50
IUUC-Ome-082007 Oryza meridionalis 25.10 2.00e-18 86.70
IUUC-Oni-082827 Oryza nivara 25.10 6.00e-18 85.10
IUUC-Opu-083159 Oryza punctata 25.30 2.00e-17 84.00
IUUC-Oru-085039 Oryza rufipogon 25.10 6.00e-18 85.10
IUUC-Osa-086258 Oryza sativa 25.10 6.00e-18 85.10
IUUC-Ola-087223 Oryzias latipes 57.71 1.00e-120 426.00
IUUC-Oga-088417 Otolemur garnettii 90.91 0.00e+00 679.00
IUUC-Oar-090435 Ovis aries 92.34 0.00e+00 726.00
IUUC-Ptr-090869 Pan troglodytes 99.52 0.00e+00 738.00
IUUC-Pan-092527 Papio anubis 98.33 0.00e+00 753.00
IUUC-Pma-094156 Petromyzon marinus 55.18 1.00e-116 413.00
IUUC-Ppa-095904 Physcomitrella patens 28.11 2.00e-12 67.00
IUUC-Pfo-097488 Poecilia formosa 52.57 2.00e-122 432.00
IUUC-Pab-097720 Pongo abelii 98.32 0.00e+00 751.00
IUUC-Pop-099618 Populus trichocarpa 28.57 1.00e-20 94.40
IUUC-Pca-100288 Procavia capensis 80.19 1.00e-172 599.00
IUUC-Ppe-101864 Prunus persica 27.46 9.00e-13 68.20
IUUC-Pva-103192 Pteropus vampyrus 93.78 0.00e+00 725.00
IUUC-Rno-106123 Rattus norvegicus 89.69 0.00e+00 649.00
IUUC-Sha-107169 Sarcophilus harrisii 80.48 4.00e-167 580.00
IUUC-Smo-109265 Selaginella moellendorffii 26.67 2.00e-13 69.70
IUUC-Sly-111551 Solanum lycopersicum 26.40 1.00e-13 71.20
IUUC-Stu-112264 Solanum tuberosum 26.40 1.00e-12 67.40
IUUC-Sar-113218 Sorex araneus 84.62 1.00e-108 385.00
IUUC-Ssc-115282 Sus scrofa 92.05 0.00e+00 697.00
IUUC-Tru-117866 Takifugu rubripes 55.43 8.00e-120 423.00
IUUC-Tca-121083 Theobroma cacao 27.51 1.00e-16 80.90
IUUC-Tae-124218 Triticum aestivum 26.77 6.00e-18 84.70
IUUC-Ttr-128585 Tursiops truncatus 90.19 0.00e+00 666.00
IUUC-Vvi-131024 Vitis vinifera 28.12 2.00e-18 87.00
IUUC-Xma-134081 Xiphophorus maculatus 53.09 1.00e-120 426.00
Created Date 25-Jun-2017

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