iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-013226

Ensembl Protein ID

ENSBTAP00000041555.2

UniProt Accession

O18971; Q1LZB7; Q8HY47; PPARG_BOVIN

Genbank Protein ID

CAA73033.1; CAA73032.1; AAN75018.1; AAI16099.1

Protein Name

Peroxisome proliferator-activated receptor gamma; Nuclear receptor subfamily 1 group C member 3

Genbank Nucleotide ID

Y12420; Y12419; AY179866; BC116098

Gene Name

PPARG; NR1C3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000001333.4	ENSBTAT00000044038.2	ENSBTAP00000041555.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	95.84	0.00e+00	977.00	IUUC-Hsa-046916

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Bos taurus

Functional Description
(View)

Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels.

Protein Sequence
(Fasta)

MGETLGDALI DPESEPFAVT VSARTSQEIT MVDTEMPFWP TNFGISSVDL SMMDDHSHAF 60
DIKPFTTVDF SSISTPHYED IPFPRADPMV ADYKYDLKLQ EYQSAIKVEP VSPPYYSEKT 120

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Nucleotide Sequence
(Fasta)

CTTTACCTCC GCCGGTGATC AGAAGCCTGC GTCTCTAAAT TCTTAAGTCC CCTTGCTTAG 60
GTGAGTCGGC TTACTCTGTA ATTGCACTCT GTTGAAATCA CTCTGTTGGT GATGCGTGTC 120

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Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0675--Receptor
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003074--1Cnucl_rcpt
IPR003077--1Cnucl_rcpt_G
IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR022590--PPARgamma_N
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF00104--Hormone_recep
PF12577--PPARgamma_N
PF00105--zf-C4

PRINTS

PR01288--PROXISOMEPAR
PR01291--PROXISOMPAGR
PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0090575--C:RNA polymerase II transcription factor complex
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0003677--F:DNA binding
GO:0008144--F:drug binding
GO:0030374--F:ligand-dependent nuclear receptor transcription coactivator activity
GO:0004879--F:RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
GO:0003707--F:steroid hormone receptor activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0008270--F:zinc ion binding
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045165--P:cell fate commitment
GO:0048469--P:cell maturation
GO:0032869--P:cellular response to insulin stimulus
GO:0030855--P:epithelial cell differentiation
GO:0042593--P:glucose homeostasis
GO:0042953--P:lipoprotein transport
GO:0045713--P:low-density lipoprotein particle receptor biosynthetic process
GO:0010742--P:macrophage derived foam cell differentiation
GO:0030224--P:monocyte differentiation
GO:0010887--P:negative regulation of cholesterol storage
GO:0060336--P:negative regulation of interferon-gamma-mediated signaling pathway
GO:0010745--P:negative regulation of macrophage derived foam cell differentiation
GO:0010871--P:negative regulation of receptor biosynthetic process
GO:0010891--P:negative regulation of sequestering of triglyceride
GO:0048662--P:negative regulation of smooth muscle cell proliferation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0035357--P:peroxisome proliferator activated receptor signaling pathway
GO:0045600--P:positive regulation of fat cell differentiation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0008217--P:regulation of blood pressure
GO:0042752--P:regulation of circadian rhythm
GO:0045598--P:regulation of fat cell differentiation
GO:0060850--P:regulation of transcription involved in cell fate commitment
GO:0006355--P:regulation of transcription, DNA-templated
GO:0055098--P:response to low-density lipoprotein particle
GO:0032526--P:response to retinoic acid
GO:0048511--P:rhythmic process
GO:0006351--P:transcription, DNA-templated
GO:0050872--P:white fat cell differentiation

KEGG

bta:281993

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001214	Ailuropoda melanoleuca	94.65	0.00e+00	956.00
IUUC-Aca-005129	Anolis carolinensis	87.98	0.00e+00	871.00
IUUC-Ame-010818	Astyanax mexicanus	65.45	0.00e+00	639.00
IUUC-Cja-019236	Callithrix jacchus	96.44	0.00e+00	979.00
IUUC-Cfa-020281	Canis familiaris	97.03	0.00e+00	990.00
IUUC-Cpo-021587	Cavia porcellus	95.40	0.00e+00	925.00
IUUC-Csa-023400	Chlorocebus sabaeus	97.68	0.00e+00	938.00
IUUC-Cho-024593	Choloepus hoffmanni	84.75	0.00e+00	840.00
IUUC-Cme-027193	Cyanidioschyzon merolae	36.96	2.90e+00	26.20
IUUC-Dre-028176	Danio rerio	60.00	8.00e-153	533.00
IUUC-Dno-029063	Dasypus novemcinctus	92.87	0.00e+00	939.00
IUUC-Dme-031794	Drosophila melanogaster	35.16	3.00e-55	210.00
IUUC-Ete-032520	Echinops telfairi	92.87	0.00e+00	937.00
IUUC-Fca-035935	Felis catus	97.23	0.00e+00	991.00
IUUC-Fal-037524	Ficedula albicollis	92.63	0.00e+00	882.00
IUUC-Gga-041223	Gallus gallus	93.05	0.00e+00	885.00
IUUC-Gac-042156	Gasterosteus aculeatus	61.94	0.00e+00	635.00
IUUC-Ggo-045265	Gorilla gorilla	95.84	0.00e+00	978.00
IUUC-Hsa-046916	Homo sapiens	95.84	0.00e+00	977.00
IUUC-Lch-049759	Latimeria chalumnae	79.55	0.00e+00	673.00
IUUC-Loc-051870	Lepisosteus oculatus	74.59	0.00e+00	754.00
IUUC-Laf-054483	Loxodonta africana	94.65	0.00e+00	962.00
IUUC-Meu-056587	Macropus eugenii	95.85	0.00e+00	906.00
IUUC-Mga-059530	Meleagris gallopavo	93.05	0.00e+00	885.00
IUUC-Mmr-060576	Microcebus murinus	95.05	0.00e+00	967.00
IUUC-Mdo-061854	Monodelphis domestica	97.26	0.00e+00	927.00
IUUC-Mmu-063724	Mus musculus	95.05	0.00e+00	970.00
IUUC-Mpu-066888	Mustela putorius furo	98.32	0.00e+00	975.00
IUUC-Mlu-067978	Myotis lucifugus	96.63	0.00e+00	1019.00
IUUC-Nle-070069	Nomascus leucogenys	96.24	0.00e+00	980.00
IUUC-Opr-070630	Ochotona princeps	92.43	0.00e+00	780.00
IUUC-Ont-071399	Oreochromis niloticus	59.33	2.00e-179	622.00
IUUC-Ocu-074862	Oryctolagus cuniculus	96.86	0.00e+00	935.00
IUUC-Ola-087266	Oryzias latipes	55.89	2.00e-159	555.00
IUUC-Oga-089143	Otolemur garnettii	95.25	0.00e+00	971.00
IUUC-Oar-089725	Ovis aries	99.41	0.00e+00	1011.00
IUUC-Ptr-091580	Pan troglodytes	96.04	0.00e+00	978.00
IUUC-Psi-093041	Pelodiscus sinensis	90.57	0.00e+00	862.00
IUUC-Pfo-097438	Poecilia formosa	59.22	6.00e-177	613.00
IUUC-Pab-098333	Pongo abelii	97.06	0.00e+00	929.00
IUUC-Pca-100861	Procavia capensis	96.23	0.00e+00	926.00
IUUC-Pva-102186	Pteropus vampyrus	86.93	0.00e+00	862.00
IUUC-Rno-105583	Rattus norvegicus	95.25	0.00e+00	969.00
IUUC-Sha-107484	Sarcophilus harrisii	96.28	0.00e+00	932.00
IUUC-Sar-112996	Sorex araneus	84.79	0.00e+00	642.00
IUUC-Ssc-115945	Sus scrofa	97.03	0.00e+00	986.00
IUUC-Tsy-119098	Tarsius syrichta	86.53	0.00e+00	850.00
IUUC-Tni-120902	Tetraodon nigroviridis	60.73	5.00e-172	597.00
IUUC-Tbe-127225	Tupaia belangeri	74.46	0.00e+00	704.00
IUUC-Ttr-129292	Tursiops truncatus	97.23	0.00e+00	992.00
IUUC-Vpa-130378	Vicugna pacos	91.10	0.00e+00	786.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence