iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	1.40e-12	49.4	31	103

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvv..g..geeffahkivLaasSsvFyalflmele.esksklmveikdvqpevfrallkFlYtgkldene 69
           +Dv++ v  +  ++ f ahk+vLaa S++F+  fl+e + +++ +  v +++vq   f  +l+F+Yt k++ +e
   Q: 31   CDVTVSVeyQgvRKDFMAHKAVLAATSKFFKEVFLNEKSvDGT-RTNVYLNEVQVADFASFLEFVYTAKVQVEE 103
           8999999552699**************************9998.*************************99875 PP

Organism

Homo sapiens

Functional Description
(View)

Transcriptional repressor. Binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression.

Protein Sequence
(Fasta)

MESGAVLLES KSSPFNLLHE MHELRLLGHL CDVTVSVEYQ GVRKDFMAHK AVLAATSKFF 60
KEVFLNEKSV DGTRTNVYLN EVQVADFASF LEFVYTAKVQ VEEDRVQRML EVAEKLKCLD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTCCTACCG GCCTGGTCCA GCGGACAGCG GCTGCAGCGG GGGCGCCGGC TGGGAGGTGA 60
GTGCGCGGCC CGTAGGCCTG GCTCCGGCCC CTCGCCGCCC GCCGCCGCCT CTTTGTCCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR000877--Prot_inh_BBI
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980--F:RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0043565--F:sequence-specific DNA binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001206--F:transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0001658--P:branching involved in ureteric bud morphogenesis
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:64412

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001934	Ailuropoda melanoleuca	81.84	0.00e+00	1072.00
IUUC-Ame-010877	Astyanax mexicanus	48.97	4.00e-157	548.00
IUUC-Bta-013307	Bos taurus	82.01	0.00e+00	1092.00
IUUC-Cja-018845	Callithrix jacchus	81.49	0.00e+00	1073.00
IUUC-Cfa-021150	Canis familiaris	80.98	0.00e+00	1049.00
IUUC-Cpo-022230	Cavia porcellus	73.68	0.00e+00	1017.00
IUUC-Csa-023584	Chlorocebus sabaeus	97.19	0.00e+00	1243.00
IUUC-Dre-028553	Danio rerio	72.00	2.00e-133	469.00
IUUC-Dor-030442	Dipodomys ordii	92.89	5.00e-144	504.00
IUUC-Eca-034020	Equus caballus	86.36	0.00e+00	1176.00
IUUC-Fca-035863	Felis catus	82.71	0.00e+00	1083.00
IUUC-Fal-037047	Ficedula albicollis	50.55	0.00e+00	632.00
IUUC-Gmo-039185	Gadus morhua	46.95	4.00e-146	511.00
IUUC-Gga-041111	Gallus gallus	67.51	0.00e+00	829.00
IUUC-Gac-041590	Gasterosteus aculeatus	67.67	8.00e-117	414.00
IUUC-Ggo-044945	Gorilla gorilla	93.53	0.00e+00	1214.00
IUUC-Itr-048332	Ictidomys tridecemlineatus	86.26	0.00e+00	1170.00
IUUC-Lch-050503	Latimeria chalumnae	62.30	0.00e+00	843.00
IUUC-Laf-054096	Loxodonta africana	87.20	0.00e+00	1185.00
IUUC-Mcc-054659	Macaca mulatta	97.05	0.00e+00	1244.00
IUUC-Meu-056837	Macropus eugenii	82.88	8.00e-131	461.00
IUUC-Mdo-063042	Monodelphis domestica	77.42	0.00e+00	1068.00
IUUC-Mmu-064286	Mus musculus	82.00	0.00e+00	1132.00
IUUC-Mpu-066332	Mustela putorius furo	84.06	0.00e+00	1135.00
IUUC-Mlu-067074	Myotis lucifugus	81.86	0.00e+00	1048.00
IUUC-Opr-071202	Ochotona princeps	78.42	0.00e+00	1029.00
IUUC-Ont-071413	Oreochromis niloticus	70.00	9.00e-126	444.00
IUUC-Ocu-074500	Oryctolagus cuniculus	81.91	0.00e+00	1069.00
IUUC-Ola-086708	Oryzias latipes	56.06	2.00e-121	429.00
IUUC-Oga-089070	Otolemur garnettii	87.06	0.00e+00	1140.00
IUUC-Oar-090397	Ovis aries	74.96	0.00e+00	941.00
IUUC-Ptr-090910	Pan troglodytes	98.73	0.00e+00	1296.00
IUUC-Pan-092780	Papio anubis	75.63	0.00e+00	905.00
IUUC-Psi-092954	Pelodiscus sinensis	76.05	0.00e+00	1033.00
IUUC-Pma-094360	Petromyzon marinus	47.06	2.00e-141	496.00
IUUC-Pfo-096628	Poecilia formosa	44.83	4.00e-139	488.00
IUUC-Pab-097636	Pongo abelii	96.46	0.00e+00	841.00
IUUC-Pca-100692	Procavia capensis	84.27	0.00e+00	932.00
IUUC-Pva-102299	Pteropus vampyrus	86.36	0.00e+00	1177.00
IUUC-Rno-104956	Rattus norvegicus	81.74	0.00e+00	1132.00
IUUC-Sha-106957	Sarcophilus harrisii	77.95	0.00e+00	1072.00
IUUC-Sar-113526	Sorex araneus	89.58	0.00e+00	669.00
IUUC-Ssc-115344	Sus scrofa	80.86	0.00e+00	1063.00
IUUC-Tru-118688	Takifugu rubripes	68.65	5.00e-124	438.00
IUUC-Ttr-128440	Tursiops truncatus	81.36	0.00e+00	1075.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence