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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Rno-104928
Ensembl Protein ID ENSRNOP00000019687.4
UniProt Accession D4A8X0; ZBTB4_RAT
Genbank Protein ID ENSRNOP00000019687
Protein Name Zinc finger and BTB domain-containing protein 4
Genbank Nucleotide ID AABR07029862
Gene Name Zbtb4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000014689.7 ENSRNOT00000019687.6 ENSRNOP00000019687.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFACRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 7.80e-11 42.6 30 129
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmelees.................................ksklmveikdvqpevfral 56
           +Dv+l+ g+++f+ah++vLaasS++F+  +l   +                                    +    e+ +v + +f+++
   Q: 30   CDVTLIAGDTKFPAHRSVLAASSPFFREALLASAPLPlppvtggsapspatttaasssssppppasphssSPPRVLELPGVPAAAFSDV 118
           9*****************************998885569*****************************976566778889********* PP
   S: 57   lkFlYtgklde 67
           l+F+Y+ +l +
   Q: 119  LNFIYSARLAL 129
           ******99975 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA.
 Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA.
Protein Sequence
(Fasta)
MPPPAEVTDP SHAPAVLRQL NEQRLRGLFC DVTLIAGDTK FPAHRSVLAA SSPFFREALL 60
ASAPLPLPPV TGGSAPSPAT TTAASSSSSP PPPASPHSSS PPRVLELPGV PAAAFSDVLN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-104928|E3,BTB_Other|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGGAAAAGGC CAGACTGGAG GGACTTGCTG AGCCACTACA CTGCTCCATG TTGGCTATGC 60
TCTCAGGTGA GAAAGTGTGG GGAAGACAGC AAAGGCAGCT ACCTTGTTCA CCCCCTGACC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-104928|E3,BTB_Other|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000210--BTB/POZ_dom
IPR000877--Prot_inh_BBI
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF00651--BTB
SMART

SM00225--BTB
SM00355--ZnF_C2H2
Gene Ontology

GO:0005694--C:chromosome
GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0046872--F:metal ion binding
GO:0008327--F:methyl-CpG binding
GO:0010428--F:methyl-CpNpG binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001227--F:transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006351--P:transcription, DNA-templated
KEGG rno:287441
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aca-004385 Anolis carolinensis 42.16 1.00e-167 583.00
IUUC-Bta-012689 Bos taurus 79.70 0.00e+00 974.00
IUUC-Cja-019922 Callithrix jacchus 77.33 0.00e+00 817.00
IUUC-Cfa-020348 Canis familiaris 81.61 0.00e+00 949.00
IUUC-Cpo-021824 Cavia porcellus 77.86 0.00e+00 1003.00
IUUC-Csa-024023 Chlorocebus sabaeus 81.03 0.00e+00 902.00
IUUC-Dno-029721 Dasypus novemcinctus 80.78 0.00e+00 981.00
IUUC-Dor-030987 Dipodomys ordii 84.37 2.00e-165 576.00
IUUC-Ete-032788 Echinops telfairi 79.97 4.00e-174 604.00
IUUC-Eca-034199 Equus caballus 84.40 0.00e+00 910.00
IUUC-Eeu-034887 Erinaceus europaeus 79.86 2.00e-118 420.00
IUUC-Fca-036123 Felis catus 89.53 8.00e-163 567.00
IUUC-Ggo-044792 Gorilla gorilla 82.94 0.00e+00 931.00
IUUC-Hsa-045806 Homo sapiens 82.17 0.00e+00 928.00
IUUC-Itr-048293 Ictidomys tridecemlineatus 84.98 0.00e+00 1051.00
IUUC-Lch-049633 Latimeria chalumnae 39.42 4.00e-151 528.00
IUUC-Laf-053666 Loxodonta africana 79.80 0.00e+00 972.00
IUUC-Mcc-055380 Macaca mulatta 82.27 0.00e+00 902.00
IUUC-Meu-056434 Macropus eugenii 63.49 0.00e+00 706.00
IUUC-Mdo-062151 Monodelphis domestica 70.71 6.00e-107 381.00
IUUC-Mmu-064025 Mus musculus 93.82 0.00e+00 1162.00
IUUC-Mpu-065808 Mustela putorius furo 81.69 0.00e+00 968.00
IUUC-Mlu-068025 Myotis lucifugus 82.15 0.00e+00 1037.00
IUUC-Opr-070749 Ochotona princeps 75.95 0.00e+00 808.00
IUUC-Ocu-074809 Oryctolagus cuniculus 81.15 0.00e+00 972.00
IUUC-Oga-088975 Otolemur garnettii 80.99 0.00e+00 1008.00
IUUC-Oar-090000 Ovis aries 80.42 1.00e-137 483.00
IUUC-Ptr-090835 Pan troglodytes 80.70 0.00e+00 907.00
IUUC-Pan-092409 Papio anubis 82.15 0.00e+00 906.00
IUUC-Pab-097964 Pongo abelii 80.81 0.00e+00 873.00
IUUC-Pca-100651 Procavia capensis 74.75 0.00e+00 893.00
IUUC-Pva-102379 Pteropus vampyrus 78.03 0.00e+00 911.00
IUUC-Sha-106756 Sarcophilus harrisii 62.65 0.00e+00 770.00
IUUC-Sar-113009 Sorex araneus 79.17 0.00e+00 874.00
IUUC-Ssc-115587 Sus scrofa 81.39 0.00e+00 945.00
Created Date 25-Jun-2017

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