iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Protein 3D Structure
PDB
Post-translational Modifications (PTMs)
dbPAF	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UDP/UBQ/UBQ_PIM	UBQ_PIM	12826399; 20064468

Classification

Family	E-value	Score	Start	End
ULD/UDP/UBQ/UBQ_PIM	1.50e-20	72.9	31	100

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_PIM

   S: 2    kltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvv 71
           ++ vkt++gk++++++++++ ++++Ke++a + g++p+++k+I+aGk+L+D+tt++++++ ++sv+h + 
   Q: 31   SIYVKTNTGKTLTVNLEPQWDIKNVKELVAPQLGLQPDDLKIIFAGKELSDATTIEQCDLGQQSVLHAIR 100
           799****************************************************************985 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

Protein Sequence
(Fasta)

MSFIFKFIAT FVRKMLELLQ FGGKTLTHTL SIYVKTNTGK TLTVNLEPQW DIKNVKELVA 60
PQLGLQPDDL KIIFAGKELS DATTIEQCDL GQQSVLHAIR LRPPVQRQKI QSATLEEEEP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAAATTGTT TTCAATTGTG CGCTTTCTGC GTGTCCACGT TTTCCTCCGA ATGGCTGCCA 60
GCTGGTGTTT GGCAACGCGT AAGTAAACAA CGATTGGCAA CACTGAAGCA TATACACTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR003977--Parkin
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF01485--IBR
PF00240--ubiquitin

PRINTS

PR01475--PARKIN

SMART

SM00647--IBR
SM00213--UBQ

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0046872--F:metal ion binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008344--P:adult locomotory behavior
GO:0000266--P:mitochondrial fission
GO:0007005--P:mitochondrion organization
GO:0000422--P:mitophagy
GO:0046329--P:negative regulation of JNK cascade
GO:0010637--P:negative regulation of mitochondrial fusion
GO:0070050--P:neuron cellular homeostasis
GO:0048477--P:oogenesis
GO:0048078--P:positive regulation of compound eye pigmentation
GO:0090141--P:positive regulation of mitochondrial fission
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:1900407--P:regulation of cellular response to oxidative stress
GO:0010821--P:regulation of mitochondrion organization
GO:0006979--P:response to oxidative stress
GO:0030382--P:sperm mitochondrion organization
GO:0007283--P:spermatogenesis
GO:0055069--P:zinc ion homeostasis

KEGG

dme:Dmel_CG10523

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001814	Ailuropoda melanoleuca	35.14	1.00e-47	182.00
IUUC-Apl-003304	Anas platyrhynchos	49.70	6.00e-93	333.00
IUUC-Aca-004908	Anolis carolinensis	57.55	3.00e-34	135.00
IUUC-Ame-011856	Astyanax mexicanus	44.66	3.00e-113	401.00
IUUC-Bta-013014	Bos taurus	41.84	2.00e-78	285.00
IUUC-Cel-018687	Caenorhabditis elegans	30.48	4.00e-48	184.00
IUUC-Cja-019579	Callithrix jacchus	57.47	4.00e-50	189.00
IUUC-Cfa-020461	Canis familiaris	35.02	1.00e-47	182.00
IUUC-Cpo-022251	Cavia porcellus	36.54	1.00e-50	192.00
IUUC-Csa-023112	Chlorocebus sabaeus	34.33	2.00e-45	174.00
IUUC-Cho-024504	Choloepus hoffmanni	30.70	3.00e-57	215.00
IUUC-Dre-028202	Danio rerio	44.23	2.00e-103	368.00
IUUC-Dno-028946	Dasypus novemcinctus	49.04	5.00e-26	108.00
IUUC-Dor-030508	Dipodomys ordii	34.53	5.00e-52	197.00
IUUC-Ete-032281	Echinops telfairi	35.02	6.00e-33	134.00
IUUC-Eca-033228	Equus caballus	37.25	5.00e-48	183.00
IUUC-Fal-037507	Ficedula albicollis	43.43	4.00e-107	380.00
IUUC-Gmo-038744	Gadus morhua	44.75	2.00e-63	235.00
IUUC-Gga-040353	Gallus gallus	43.52	2.00e-107	381.00
IUUC-Gac-042519	Gasterosteus aculeatus	39.50	3.00e-101	361.00
IUUC-Hsa-046016	Homo sapiens	42.19	1.00e-103	369.00
IUUC-Itr-048744	Ictidomys tridecemlineatus	41.56	2.00e-92	331.00
IUUC-Loc-052389	Lepisosteus oculatus	42.71	2.00e-101	362.00
IUUC-Mcc-054933	Macaca mulatta	42.59	6.00e-102	363.00
IUUC-Meu-055963	Macropus eugenii	36.52	1.00e-61	229.00
IUUC-Mga-059626	Meleagris gallopavo	58.21	4.00e-20	88.20
IUUC-Mmr-061566	Microcebus murinus	54.84	3.00e-55	207.00
IUUC-Mdo-061952	Monodelphis domestica	61.40	8.00e-19	83.60
IUUC-Mmu-063561	Mus musculus	43.61	2.00e-109	388.00
IUUC-Mpu-065799	Mustela putorius furo	35.13	3.00e-50	191.00
IUUC-Mlu-068134	Myotis lucifugus	38.08	4.00e-61	227.00
IUUC-Nle-070078	Nomascus leucogenys	34.84	2.00e-48	184.00
IUUC-Opr-070541	Ochotona princeps	42.25	2.00e-96	345.00
IUUC-Ont-071743	Oreochromis niloticus	40.09	2.00e-96	345.00
IUUC-Ola-086426	Oryzias latipes	50.29	8.00e-48	181.00
IUUC-Oga-088867	Otolemur garnettii	42.41	3.00e-100	357.00
IUUC-Oar-089365	Ovis aries	39.02	4.00e-69	254.00
IUUC-Ptr-091371	Pan troglodytes	42.44	5.00e-103	367.00
IUUC-Pan-092443	Papio anubis	34.68	4.00e-46	177.00
IUUC-Psi-093851	Pelodiscus sinensis	36.48	2.00e-37	147.00
IUUC-Pfo-097194	Poecilia formosa	40.88	1.00e-101	362.00
IUUC-Pab-097999	Pongo abelii	34.99	3.00e-51	194.00
IUUC-Pca-100410	Procavia capensis	38.36	1.00e-73	269.00
IUUC-Pva-102300	Pteropus vampyrus	39.28	7.00e-85	306.00
IUUC-Rno-105556	Rattus norvegicus	37.09	1.00e-49	189.00
IUUC-Sar-113121	Sorex araneus	59.09	7.00e-36	143.00
IUUC-Ssc-116435	Sus scrofa	35.59	1.00e-47	182.00
IUUC-Tgu-117489	Taeniopygia guttata	42.49	1.00e-104	372.00
IUUC-Tru-117927	Takifugu rubripes	42.28	7.00e-111	393.00
IUUC-Tsy-119372	Tarsius syrichta	49.39	5.00e-85	307.00
IUUC-Tni-120043	Tetraodon nigroviridis	39.10	3.00e-99	354.00
IUUC-Tbe-127539	Tupaia belangeri	36.59	1.00e-53	202.00
IUUC-Ttr-129149	Tursiops truncatus	42.23	5.00e-104	370.00
IUUC-Vpa-130439	Vicugna pacos	31.70	4.00e-62	231.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence