iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Phospho.ELM	PHOSIDA	BioGRID	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.10e-18	67.2	124	181

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           ++e+v++lyd+ +++ ++L +kkG+ + +i  e+ +e W+++ ++  g+ G++P  +vekl
   Q: 124  NLEYVRTLYDFPGNDAEDLPFKKGELLVII--EKPEEQWWSA-RNKDGRVGMIPVPYVEKL 181
           5789**************************..88999***99.6**************997 PP

Organism

Mus musculus

Functional Description
(View)

Interacts with DOCK2 and EPOR. Interacts with phosphorylated CBLB and IRS4 (By similarity). Interacts with INPP5D/SHIP1.

Protein Sequence
(Fasta)

MSSARFDSSD RSAWYMGPVT RQEAQTRLQG QRHGMFLVRD SSTCPGDYVL SVSENSRVSH 60
YIINSLPNRR FKIGDQEFDH LPALLEFYKI HYLDTTTLIE PAPRYPSPPV GSVSAPNLPT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGGTGCCCG GCTGCTTCTC CCGCGTCCGC CATTTTGTTG CTGTGGCTAT TGGGAGCGGG 60
CTGGGTAAGA CTGCTCGGGA GGCGCGACTC TTGTTGGAGT GCGGTGCTTC GTGTGACCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain

Interpro

IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005913--C:cell-cell adherens junction
GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0098641--F:cadherin binding involved in cell-cell adhesion
GO:0003723--F:RNA binding
GO:0009887--P:animal organ morphogenesis
GO:0009952--P:anterior/posterior pattern specification
GO:0001568--P:blood vessel development
GO:0007507--P:heart development
GO:0060017--P:parathyroid gland development
GO:0007389--P:pattern specification process
GO:0008284--P:positive regulation of cell proliferation
GO:1900026--P:positive regulation of substrate adhesion-dependent cell spreading
GO:0048538--P:thymus development

KEGG

mmu:12929

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002025	Ailuropoda melanoleuca	97.24	2.00e-171	594.00
IUUC-Apl-004166	Anas platyrhynchos	89.07	1.00e-158	551.00
IUUC-Aca-004695	Anolis carolinensis	53.22	9.00e-84	303.00
IUUC-Ame-011285	Astyanax mexicanus	79.48	1.00e-138	485.00
IUUC-Bta-013076	Bos taurus	76.35	9.00e-112	396.00
IUUC-Cja-019850	Callithrix jacchus	96.55	3.00e-170	590.00
IUUC-Cfa-020428	Canis familiaris	96.55	4.00e-170	590.00
IUUC-Cpo-022079	Cavia porcellus	95.86	6.00e-169	586.00
IUUC-Csa-023877	Chlorocebus sabaeus	96.21	6.00e-170	589.00
IUUC-Cin-025128	Ciona intestinalis	50.47	4.00e-80	291.00
IUUC-Csv-026340	Ciona savignyi	47.93	3.00e-70	258.00
IUUC-Dre-027833	Danio rerio	80.34	2.00e-134	471.00
IUUC-Dno-029510	Dasypus novemcinctus	96.21	1.00e-169	588.00
IUUC-Dor-030297	Dipodomys ordii	96.70	7.00e-176	609.00
IUUC-Dme-031600	Drosophila melanogaster	44.22	6.00e-68	250.00
IUUC-Eca-033810	Equus caballus	96.90	7.00e-171	592.00
IUUC-Fca-036412	Felis catus	97.24	2.00e-171	594.00
IUUC-Fal-037170	Ficedula albicollis	91.03	1.00e-153	535.00
IUUC-Gga-040733	Gallus gallus	90.69	1.00e-141	495.00
IUUC-Gac-042398	Gasterosteus aculeatus	79.49	6.00e-143	499.00
IUUC-Ggo-044447	Gorilla gorilla	95.48	7.00e-113	399.00
IUUC-Hsa-046989	Homo sapiens	96.55	4.00e-170	590.00
IUUC-Itr-048092	Ictidomys tridecemlineatus	97.24	8.00e-171	592.00
IUUC-Kpa-049154	Komagataella pastoris	42.42	1.00e-10	60.80
IUUC-Lch-050385	Latimeria chalumnae	59.86	3.00e-99	354.00
IUUC-Loc-052916	Lepisosteus oculatus	85.25	3.00e-148	517.00
IUUC-Laf-053545	Loxodonta africana	96.00	1.00e-113	401.00
IUUC-Mga-059586	Meleagris gallopavo	93.10	9.00e-155	539.00
IUUC-Mvi-060518	Microbotryum violaceum	37.70	1.00e-10	60.50
IUUC-Mdo-061868	Monodelphis domestica	88.62	1.00e-157	548.00
IUUC-Mpu-065863	Mustela putorius furo	96.90	5.00e-171	593.00
IUUC-Mlu-067290	Myotis lucifugus	96.21	1.00e-169	588.00
IUUC-Nle-069118	Nomascus leucogenys	96.55	4.00e-170	590.00
IUUC-Opr-070565	Ochotona princeps	94.06	5.00e-172	596.00
IUUC-Ont-071608	Oreochromis niloticus	81.15	2.00e-147	514.00
IUUC-Oan-072801	Ornithorhynchus anatinus	88.45	9.00e-162	562.00
IUUC-Ocu-073759	Oryctolagus cuniculus	96.55	4.00e-170	590.00
IUUC-Ola-086748	Oryzias latipes	74.59	1.00e-123	436.00
IUUC-Oga-088248	Otolemur garnettii	97.24	6.00e-171	592.00
IUUC-Oar-089525	Ovis aries	76.11	4.00e-122	430.00
IUUC-Ptr-091553	Pan troglodytes	96.55	4.00e-170	590.00
IUUC-Pan-092639	Papio anubis	96.55	4.00e-170	590.00
IUUC-Psi-093546	Pelodiscus sinensis	86.82	4.00e-101	360.00
IUUC-Pma-094340	Petromyzon marinus	58.97	1.00e-103	369.00
IUUC-Pfo-096090	Poecilia formosa	81.37	1.00e-146	511.00
IUUC-Pab-097876	Pongo abelii	95.71	3.00e-134	470.00
IUUC-Pca-100447	Procavia capensis	96.90	8.00e-171	592.00
IUUC-Pva-102346	Pteropus vampyrus	97.23	5.00e-170	589.00
IUUC-Rno-106017	Rattus norvegicus	98.62	1.00e-172	598.00
IUUC-Sha-106511	Sarcophilus harrisii	88.14	6.00e-102	362.00
IUUC-Sar-113583	Sorex araneus	95.86	3.00e-169	587.00
IUUC-Ssc-115339	Sus scrofa	95.86	4.00e-168	583.00
IUUC-Tgu-116454	Taeniopygia guttata	90.66	6.00e-98	349.00
IUUC-Tru-118580	Takifugu rubripes	77.17	3.00e-137	481.00
IUUC-Tsy-119327	Tarsius syrichta	95.53	1.00e-166	578.00
IUUC-Tni-120626	Tetraodon nigroviridis	77.56	1.00e-138	485.00
IUUC-Ttr-128248	Tursiops truncatus	95.86	4.00e-169	587.00
IUUC-Xtr-132626	Xenopus tropicalis	86.47	2.00e-152	531.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence