iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028606

UUCD1 version

UUC-DaR-00132

Ensembl Protein ID

ENSDARP00000079296.4

UniProt Accession

Q08BW5; Q08BW5_DANRE

Genbank Protein ID

AAI24529.1; ABM68033.1; CAJ13513.1; CBY83934.1

Protein Name

Cytokine inducible SH2 containing protein; Cytokine inducible SH2-containing protein; Cytokine inducible SH2-containing protein A; Cytokine-inducible SH2-containing protein

Genbank Nucleotide ID

CR847825; EF195760; AM040611; FR749998

Gene Name

cish; cis; CISH; cish.a

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000060316.5	ENSDART00000136538.2	ENSDARP00000121026.1
ENSDARG00000060316.5	ENSDART00000140108.1	ENSDARP00000116149.1
ENSDARG00000060316.5	ENSDART00000084861.4	ENSDARP00000079296.4

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	37.66	1.00e-31	133.00	IUUC-Hsa-046678

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Danio rerio

Protein Sequence
(Fasta)

MILCVEGPSP RALLPFSSPR RIDEPFLTIE DASKDYRALT LNFSYLDASG WYWGGISASE 60
AHSVLKGASE GTFLIRDSSH PDYMLTLSVK TVRGPTNVRI EYRQCRFSLD SSSPARSHLQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACATCAGGA AGCAATTACC GACAATAAAA CTCCCAAATG AGTCATTGCA GGCTCATTCC 60
AGCGCTAGTT CGTTACTCAC GAGACCACCG TATGCTAGAC TGAGAGAGAG AATTCTGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR028425--CIS
IPR000980--SH2
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

PRINTS

PR00401--SH2DOMAIN

SMART

SM00252--SH2
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0045647--P:negative regulation of erythrocyte differentiation
GO:1903707--P:negative regulation of hemopoiesis
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0045620--P:negative regulation of lymphocyte differentiation
GO:0045638--P:negative regulation of myeloid cell differentiation
GO:0006469--P:negative regulation of protein kinase activity
GO:0016567--P:protein ubiquitination

KEGG

dre:767678

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001189	Ailuropoda melanoleuca	45.45	1.00e-40	160.00
IUUC-Aca-004372	Anolis carolinensis	48.40	3.00e-43	168.00
IUUC-Ame-010787	Astyanax mexicanus	60.35	2.00e-70	258.00
IUUC-Bta-012826	Bos taurus	46.67	7.00e-41	160.00
IUUC-Cja-020004	Callithrix jacchus	45.69	2.00e-39	156.00
IUUC-Cfa-020150	Canis familiaris	45.45	7.00e-40	157.00
IUUC-Csa-023173	Chlorocebus sabaeus	45.73	8.00e-40	157.00
IUUC-Dno-028956	Dasypus novemcinctus	45.45	1.00e-40	159.00
IUUC-Dor-030148	Dipodomys ordii	45.64	4.00e-39	154.00
IUUC-Ete-032313	Echinops telfairi	43.78	2.00e-39	155.00
IUUC-Eca-033422	Equus caballus	46.46	3.00e-42	164.00
IUUC-Eeu-034806	Erinaceus europaeus	45.92	1.00e-39	156.00
IUUC-Fca-036374	Felis catus	46.46	9.00e-41	160.00
IUUC-Fal-036801	Ficedula albicollis	42.74	2.00e-45	175.00
IUUC-Gmo-038483	Gadus morhua	54.55	3.00e-51	194.00
IUUC-Gga-040891	Gallus gallus	48.92	2.00e-43	169.00
IUUC-Gac-042147	Gasterosteus aculeatus	56.32	1.00e-47	182.00
IUUC-Ggo-045511	Gorilla gorilla	43.72	4.00e-39	154.00
IUUC-Hsa-046678	Homo sapiens	37.60	1.00e-39	156.00
IUUC-Itr-048397	Ictidomys tridecemlineatus	45.45	2.00e-41	162.00
IUUC-Lch-050555	Latimeria chalumnae	49.18	6.00e-46	177.00
IUUC-Laf-054141	Loxodonta africana	45.45	1.00e-42	166.00
IUUC-Mcc-055401	Macaca mulatta	45.73	8.00e-40	157.00
IUUC-Mga-059515	Meleagris gallopavo	48.92	3.00e-43	168.00
IUUC-Mmr-060848	Microcebus murinus	45.96	2.00e-40	159.00
IUUC-Mmu-063348	Mus musculus	44.95	2.00e-41	162.00
IUUC-Mpu-065834	Mustela putorius furo	44.44	6.00e-40	157.00
IUUC-Mlu-067687	Myotis lucifugus	40.08	2.00e-42	165.00
IUUC-Nle-069277	Nomascus leucogenys	39.15	1.00e-39	156.00
IUUC-Ont-071890	Oreochromis niloticus	55.25	9.00e-47	179.00
IUUC-Oan-073672	Ornithorhynchus anatinus	44.28	3.00e-41	162.00
IUUC-Ocu-073875	Oryctolagus cuniculus	44.95	5.00e-41	161.00
IUUC-Ola-087140	Oryzias latipes	52.17	9.00e-31	125.00
IUUC-Oga-087943	Otolemur garnettii	41.02	8.00e-42	163.00
IUUC-Oar-090194	Ovis aries	46.67	6.00e-41	160.00
IUUC-Ptr-090934	Pan troglodytes	43.72	5.00e-39	154.00
IUUC-Pan-092121	Papio anubis	45.23	6.00e-40	157.00
IUUC-Pfo-096313	Poecilia formosa	54.97	2.00e-53	201.00
IUUC-Pab-098439	Pongo abelii	38.37	6.00e-40	157.00
IUUC-Pca-101010	Procavia capensis	38.37	3.00e-42	165.00
IUUC-Pva-103112	Pteropus vampyrus	45.96	6.00e-42	164.00
IUUC-Rno-105917	Rattus norvegicus	44.44	2.00e-40	159.00
IUUC-Sar-113001	Sorex araneus	45.92	6.00e-41	160.00
IUUC-Tgu-117338	Taeniopygia guttata	50.00	3.00e-44	171.00
IUUC-Tru-118511	Takifugu rubripes	52.76	7.00e-41	159.00
IUUC-Tsy-119434	Tarsius syrichta	45.96	3.00e-40	158.00
IUUC-Tni-119837	Tetraodon nigroviridis	56.52	1.00e-42	166.00
IUUC-Vpa-130443	Vicugna pacos	47.18	2.00e-42	165.00
IUUC-Xtr-131784	Xenopus tropicalis	47.09	5.00e-38	150.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence