iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000032578.7	ENSMUST00000085102.5	ENSMUSP00000082183.5
ENSMUSG00000032578.7	ENSMUST00000168260.1	ENSMUSP00000127523.1
ENSMUSG00000032578.7	ENSMUST00000167072.1	ENSMUSP00000129941.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	7.80e-15	55.6	209	256

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 1    lsklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
           l++++++rs+ rSLqhLCRl+I+r++ +     +d+LPLP+++ dYL+++++q
   Q: 209  LVQPFVRRSSARSLQHLCRLVINRLVAD-----VDCLPLPRRMADYLRQYPFQ 256
           57999***********************.....8****************986 PP

Organism

Mus musculus

Functional Description
(View)

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).

Protein Sequence
(Fasta)

MVLCVQGSCP LLAVEQIGRR PLWAQSLELP GPAMQPLPTG AFPEEVTEET PVQAENEPKV 60
LDPEGDLLCI AKTFSYLRES GWYWGSITAS EARQHLQKMP EGTFLVRDST HPSYLFTLSV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAATTCAATT TTAAAACAAA AACAAACAAG CCATCGACAG GGCTGTCTGG GAGCTGACTA 60
TCTCTGTTTA CTGACTCAAG AGGGTAATTT CCCCAACTGT CGGTCCACTC AGAGATTAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0341--Growth regulation
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0734--Signal transduction inhibitor
KW-0833--Ubl conjugation pathway

Interpro

IPR028425--CIS
IPR000980--SH2
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

PRINTS

PR00401--SH2DOMAIN

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0007205--P:protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0016567--P:protein ubiquitination
GO:0040008--P:regulation of growth

KEGG

mmu:12700

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001189	Ailuropoda melanoleuca	90.48	7.00e-119	419.00
IUUC-Aca-004372	Anolis carolinensis	64.23	6.00e-89	320.00
IUUC-Ame-010787	Astyanax mexicanus	45.14	3.00e-50	191.00
IUUC-Bta-012826	Bos taurus	88.72	2.00e-126	444.00
IUUC-Cja-020004	Callithrix jacchus	89.56	2.00e-113	401.00
IUUC-Cfa-020150	Canis familiaris	89.16	7.00e-112	396.00
IUUC-Csa-023173	Chlorocebus sabaeus	88.76	1.00e-111	395.00
IUUC-Dre-028606	Danio rerio	43.58	5.00e-33	134.00
IUUC-Dno-028956	Dasypus novemcinctus	85.94	6.00e-120	423.00
IUUC-Dor-030148	Dipodomys ordii	74.71	6.00e-103	366.00
IUUC-Ete-032313	Echinops telfairi	82.75	9.00e-103	366.00
IUUC-Eca-033422	Equus caballus	91.83	2.00e-131	461.00
IUUC-Eeu-034806	Erinaceus europaeus	89.16	3.00e-109	387.00
IUUC-Fca-036374	Felis catus	90.66	8.00e-124	436.00
IUUC-Fal-036801	Ficedula albicollis	65.38	3.00e-86	311.00
IUUC-Gmo-038483	Gadus morhua	38.76	2.00e-36	145.00
IUUC-Gga-040891	Gallus gallus	65.25	5.00e-81	293.00
IUUC-Gac-042147	Gasterosteus aculeatus	40.15	8.00e-35	140.00
IUUC-Ggo-045511	Gorilla gorilla	88.40	2.00e-110	391.00
IUUC-Hsa-046678	Homo sapiens	88.37	3.00e-114	404.00
IUUC-Itr-048397	Ictidomys tridecemlineatus	93.77	8.00e-134	469.00
IUUC-Lch-050555	Latimeria chalumnae	56.60	3.00e-71	261.00
IUUC-Laf-054141	Loxodonta africana	87.98	3.00e-123	434.00
IUUC-Mcc-055401	Macaca mulatta	87.95	5.00e-110	390.00
IUUC-Meu-056592	Macropus eugenii	69.48	2.00e-92	331.00
IUUC-Mga-059515	Meleagris gallopavo	65.20	5.00e-77	280.00
IUUC-Mmr-060848	Microcebus murinus	91.97	6.00e-120	423.00
IUUC-Mdo-062720	Monodelphis domestica	67.32	1.00e-92	332.00
IUUC-Mpu-065834	Mustela putorius furo	90.27	1.00e-121	428.00
IUUC-Mlu-067687	Myotis lucifugus	85.21	1.00e-101	362.00
IUUC-Nle-069277	Nomascus leucogenys	87.60	3.00e-113	400.00
IUUC-Ont-071890	Oreochromis niloticus	47.64	7.00e-38	150.00
IUUC-Oan-073672	Ornithorhynchus anatinus	64.86	1.00e-85	309.00
IUUC-Ocu-073875	Oryctolagus cuniculus	90.36	5.00e-122	430.00
IUUC-Ola-087140	Oryzias latipes	43.05	9.00e-25	105.00
IUUC-Oga-087943	Otolemur garnettii	90.66	4.00e-122	430.00
IUUC-Oar-090194	Ovis aries	88.10	6.00e-122	429.00
IUUC-Ptr-090934	Pan troglodytes	89.16	4.00e-111	394.00
IUUC-Pan-092121	Papio anubis	87.60	3.00e-114	404.00
IUUC-Psi-093733	Pelodiscus sinensis	62.40	8.00e-82	296.00
IUUC-Pfo-096313	Poecilia formosa	49.75	4.00e-44	171.00
IUUC-Pab-098439	Pongo abelii	87.98	5.00e-113	400.00
IUUC-Pca-101010	Procavia capensis	87.98	3.00e-122	431.00
IUUC-Pva-103112	Pteropus vampyrus	89.88	6.00e-127	446.00
IUUC-Rno-105917	Rattus norvegicus	96.11	6.00e-130	456.00
IUUC-Sha-106954	Sarcophilus harrisii	66.54	2.00e-93	335.00
IUUC-Smo-109292	Selaginella moellendorffii	31.15	1.90e-01	30.80
IUUC-Sar-113001	Sorex araneus	89.56	2.00e-115	408.00
IUUC-Ssc-115922	Sus scrofa	89.36	8.00e-65	238.00
IUUC-Tgu-117338	Taeniopygia guttata	65.74	2.00e-83	301.00
IUUC-Tru-118511	Takifugu rubripes	43.72	2.00e-31	128.00
IUUC-Tsy-119434	Tarsius syrichta	90.36	8.00e-115	405.00
IUUC-Ttr-128340	Tursiops truncatus	76.26	3.00e-84	304.00
IUUC-Vpa-130443	Vicugna pacos	89.88	6.00e-133	466.00
IUUC-Xtr-131784	Xenopus tropicalis	51.45	3.00e-69	254.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence