iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cfa-020816

Ensembl Protein ID

ENSCAFP00000010452.3

UniProt Accession

E2RBB8; E2RBB8_CANLF

Genbank Protein ID

ENSCAFP00000010452

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AAEX03015802

Gene Name

LYN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000007034.3	ENSCAFT00000011282.3	ENSCAFP00000010452.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	4.40e-15	55.7	66	122

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           + v +ly+y++ + d+L++kkG++++v+   e+ ++W+k+++  ++++G++P+n+v+k++
   Q: 66   DIVVALYPYDGIHPDDLSFKKGEKMKVL---EELGEWWKAKSLSTKREGFIPSNYVAKVN 122
           5799************************...8999***********************97 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MGCIKSKRKD NLNDEGIDLK TQPVRNTDRT IYVRDPTSNK QQRPVSESQL LPGQRFQTKD 60
PEEQGDIVVA LYPYDGIHPD DLSFKKGEKM KVLEELGEWW KAKSLSTKRE GFIPSNYVAK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTTGGGTTT AACCATTAGG CAAATTTAGC TTCCTGGTTT CAGAAAGAGA AAACACACCC 60
ACAAAAAGAA AAACCCAGGC CCGTGGGAAC AAGTAACTTC CTCCTCCTGG GGCTACTTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005794--C:Golgi apparatus
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0001782--P:B cell homeostasis
GO:0050853--P:B cell receptor signaling pathway
GO:0016477--P:cell migration
GO:0006974--P:cellular response to DNA damage stimulus
GO:0071300--P:cellular response to retinoic acid
GO:0007417--P:central nervous system development
GO:0006935--P:chemotaxis
GO:0097028--P:dendritic cell differentiation
GO:0030218--P:erythrocyte differentiation
GO:0002774--P:Fc receptor mediated inhibitory signaling pathway
GO:0002431--P:Fc receptor mediated stimulatory signaling pathway
GO:0006954--P:inflammatory response
GO:0045087--P:innate immune response
GO:0035556--P:intracellular signal transduction
GO:0031663--P:lipopolysaccharide-mediated signaling pathway
GO:0030889--P:negative regulation of B cell proliferation
GO:0070373--P:negative regulation of ERK1 and ERK2 cascade
GO:0043407--P:negative regulation of MAP kinase activity
GO:0070667--P:negative regulation of mast cell proliferation
GO:0002762--P:negative regulation of myeloid leukocyte differentiation
GO:0034136--P:negative regulation of toll-like receptor 2 signaling pathway
GO:0034144--P:negative regulation of toll-like receptor 4 signaling pathway
GO:0031175--P:neuron projection development
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0002576--P:platelet degranulation
GO:0050861--P:positive regulation of B cell receptor signaling pathway
GO:0030335--P:positive regulation of cell migration
GO:2000670--P:positive regulation of dendritic cell apoptotic process
GO:0070668--P:positive regulation of mast cell proliferation
GO:0010976--P:positive regulation of neuron projection development
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0070304--P:positive regulation of stress-activated protein kinase signaling cascade
GO:0042531--P:positive regulation of tyrosine phosphorylation of STAT protein
GO:0002902--P:regulation of B cell apoptotic process
GO:0050855--P:regulation of B cell receptor signaling pathway
GO:0033628--P:regulation of cell adhesion mediated by integrin
GO:0050707--P:regulation of cytokine secretion
GO:0045646--P:regulation of erythrocyte differentiation
GO:0050727--P:regulation of inflammatory response
GO:0043304--P:regulation of mast cell degranulation
GO:0090025--P:regulation of monocyte chemotaxis
GO:0090330--P:regulation of platelet aggregation
GO:0051279--P:regulation of release of sequestered calcium ion into cytosol
GO:0009725--P:response to hormone
GO:0002513--P:tolerance induction to self antigen
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001812	Ailuropoda melanoleuca	99.41	0.00e+00	1060.00
IUUC-Apl-004139	Anas platyrhynchos	88.97	0.00e+00	956.00
IUUC-Aca-004333	Anolis carolinensis	87.18	0.00e+00	929.00
IUUC-Ame-011257	Astyanax mexicanus	75.97	0.00e+00	817.00
IUUC-Bta-013257	Bos taurus	98.05	0.00e+00	1053.00
IUUC-Cja-018827	Callithrix jacchus	97.27	0.00e+00	1042.00
IUUC-Cpo-021423	Cavia porcellus	96.48	0.00e+00	1031.00
IUUC-Csa-024244	Chlorocebus sabaeus	97.07	0.00e+00	1039.00
IUUC-Dre-028518	Danio rerio	76.31	0.00e+00	811.00
IUUC-Dno-029322	Dasypus novemcinctus	98.05	0.00e+00	1044.00
IUUC-Dor-030706	Dipodomys ordii	87.89	0.00e+00	919.00
IUUC-Eca-034193	Equus caballus	98.63	0.00e+00	1053.00
IUUC-Fal-037273	Ficedula albicollis	89.08	0.00e+00	959.00
IUUC-Gmo-039677	Gadus morhua	75.11	0.00e+00	724.00
IUUC-Gga-040417	Gallus gallus	85.55	0.00e+00	912.00
IUUC-Gac-042490	Gasterosteus aculeatus	71.32	0.00e+00	785.00
IUUC-Ggo-045096	Gorilla gorilla	97.07	0.00e+00	1040.00
IUUC-Hsa-046214	Homo sapiens	97.07	0.00e+00	1040.00
IUUC-Itr-048354	Ictidomys tridecemlineatus	98.83	0.00e+00	1057.00
IUUC-Lch-049991	Latimeria chalumnae	81.94	0.00e+00	867.00
IUUC-Loc-052309	Lepisosteus oculatus	77.91	0.00e+00	838.00
IUUC-Laf-053568	Loxodonta africana	97.66	0.00e+00	1046.00
IUUC-Mcc-054849	Macaca mulatta	97.07	0.00e+00	1039.00
IUUC-Meu-056170	Macropus eugenii	78.32	0.00e+00	797.00
IUUC-Mmr-061519	Microcebus murinus	98.05	0.00e+00	1050.00
IUUC-Mdo-062090	Monodelphis domestica	81.64	0.00e+00	886.00
IUUC-Mmu-063760	Mus musculus	97.07	0.00e+00	1040.00
IUUC-Mpu-065677	Mustela putorius furo	98.63	0.00e+00	1053.00
IUUC-Mlu-067386	Myotis lucifugus	96.88	0.00e+00	1040.00
IUUC-Nle-069742	Nomascus leucogenys	97.46	0.00e+00	1043.00
IUUC-Ont-071537	Oreochromis niloticus	72.57	0.00e+00	786.00
IUUC-Oan-073193	Ornithorhynchus anatinus	94.55	0.00e+00	1012.00
IUUC-Ocu-074501	Oryctolagus cuniculus	98.44	0.00e+00	1051.00
IUUC-Ola-086726	Oryzias latipes	70.57	0.00e+00	781.00
IUUC-Oga-088069	Otolemur garnettii	97.08	0.00e+00	1042.00
IUUC-Oar-090091	Ovis aries	97.85	0.00e+00	1047.00
IUUC-Ptr-091409	Pan troglodytes	97.07	0.00e+00	1040.00
IUUC-Pan-092268	Papio anubis	97.07	0.00e+00	1040.00
IUUC-Psi-093685	Pelodiscus sinensis	88.20	0.00e+00	951.00
IUUC-Pfo-096217	Poecilia formosa	71.60	0.00e+00	784.00
IUUC-Pab-098601	Pongo abelii	97.27	0.00e+00	1042.00
IUUC-Pva-102160	Pteropus vampyrus	86.55	0.00e+00	901.00
IUUC-Rno-105557	Rattus norvegicus	97.07	0.00e+00	1044.00
IUUC-Sha-106643	Sarcophilus harrisii	93.19	0.00e+00	1004.00
IUUC-Sar-113555	Sorex araneus	94.77	2.00e-172	598.00
IUUC-Ssc-116317	Sus scrofa	91.62	0.00e+00	971.00
IUUC-Tgu-116865	Taeniopygia guttata	89.28	0.00e+00	961.00
IUUC-Tru-118284	Takifugu rubripes	71.79	0.00e+00	783.00
IUUC-Tsy-119440	Tarsius syrichta	93.55	0.00e+00	982.00
IUUC-Tni-120005	Tetraodon nigroviridis	71.35	0.00e+00	776.00
IUUC-Ttr-128481	Tursiops truncatus	83.98	0.00e+00	858.00
IUUC-Xtr-131907	Xenopus tropicalis	76.79	0.00e+00	803.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence