iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-093256

Ensembl Protein ID

ENSPSIP00000002612.1

UniProt Accession

K7F3K2; K7F3K2_PELSI

Genbank Protein ID

ENSPSIP00000002612

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AGCU01054215

Gene Name

USP45

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000002556.1	ENSPSIT00000002621.1	ENSPSIP00000002612.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	7.40e-82	275.2	192	821

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp.............kepkgellkslqklfeelwkskkkavsprellka 76
           +G++NlgNtC++N+v+Q L++++ l el+ e k++ ++ + +              ++ g+l++++ ++++++ +  k+  sp+ l+++
   Q: 192  KGINNLGNTCFFNAVMQNLAQTHMLNELMYEMKEKGIKLKISqaedsqldplvvnLSSPGPLTSAMFSFLHSMREAGKGPLSPKVLFSQ 280
           59*****************************66666665544445555566666666666***************************** PP
   S: 77   lkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknk......slisdlFqgqlksqikclec 159
           l+++a++f+g++qqD+qE+l++lld+++ e +k+ +  + +++++ ++++ de+ ++k k         ++i+++F g+l+s+++c+ec
   Q: 281  LCQKAPRFKGFQQQDSQELLHYLLDAMRIEETKRIQAGILKAFNNPTTKTADEETKRKVKAFGregvkmNFIDRIFVGELTSTVMCEEC 369
           ******************************999888888888888877777775444444433566666******************** PP
   S: 160  dnvssreepfldlslpvpgkeetkke............................................................... 185
           +n+s+ +epf+dlslp+ +++ +k++                                                               
   Q: 370  ENISTVKEPFIDLSLPIIEERVSKPLllgrtskcknvqeadlgqfkcsaitvpnnlqtkitkrhsltkdknqlnherslarktssgeee 458
           *********************99888*************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 459  rspvimhekrklevegsgvlyseaiktttesavngsqtegsekevshsessvdadseasegesaakqvvsgrcsntsdlhvnelnhlpv 547
           ***************************************************************************************** PP
   S: 186  ................................................................................slqdcLesf 194
                                                                                           s+q+cL +f
   Q: 548  niklphnkpsdsnnevitsaisklsfstiandseepisgdpsfslsnnsvfsveksplsqnpqnafqtlsqsyitsskecSVQSCLYQF 636
           ***************************************************************************************** PP
   S: 195  tkeeelegenkyycekckkkqe...................aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspf 264
           t+ e l g+nk+ ce+c+++++                   a+k+l ++++P +L+lhLkRf  ++++ s +k+n++v+fpl Ldl+pf
   Q: 637  TSVELLMGNNKLLCENCTERKQkyqkkthttekkteglytnARKQLLISTVPAILVLHLKRF--HQAGLSLRKVNRHVDFPLILDLAPF 723
           ******************88888999999999999999999*********************..9999********************* PP
   S: 265  ctspeekqke..kkkYeLiavvvHsGslssGHYvayvkn..........................ekgkWllfdDskVtevkeeevlee 325
           c+ +++++++  ++ Y L+++v H Gs+++GHY ayvk                           + g+W++++D +V+ v+e++vl+ 
   Q: 724  CSASCKNVTDktRVLYTLYGIVEHNGSMRGGHYAAYVKVrtaskkllehitinknvqglkeavgsSAGQWVYVSDVHVQMVPESRVLN- 811
           ***988876555899************************999999999999999999999888888999*******************. PP
   S: 326  tgstaYvlfYkr 337
             s+aY+lfY+r
   Q: 812  --SQAYLLFYER 821
           ..********98 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

MRVKDPLRAN PEKNKKNKRP NRPQDEDSSD DIAGLTCQHV SQAVDVHHVK RVVAQNVWSI 60
CSECLKERRI KDGDPVISSD IWLCLKCGSQ GCSQNSEGQH SLKHFQSAHT EPHCIVINLR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCGGGTGA AAGATCCATT GAGGGCTAAC CCTGAAAAAA ACAAGAAAAA CAAAAGGCCT 60
AATAGGCCTC AGGATGAAGA CTCTTCAGAT GATATTGCAG GTAAATAAAT TCTGTGACAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

pss:102448797

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002331	Ailuropoda melanoleuca	60.79	0.00e+00	878.00
IUUC-Apl-003512	Anas platyrhynchos	82.08	0.00e+00	1321.00
IUUC-Aca-004284	Anolis carolinensis	72.32	0.00e+00	1139.00
IUUC-Ame-010735	Astyanax mexicanus	60.31	6.00e-85	307.00
IUUC-Bta-012880	Bos taurus	67.60	0.00e+00	1033.00
IUUC-Cja-019144	Callithrix jacchus	66.06	0.00e+00	1066.00
IUUC-Cfa-020971	Canis familiaris	69.53	1.00e-180	626.00
IUUC-Cpo-022497	Cavia porcellus	59.29	0.00e+00	919.00
IUUC-Csa-023910	Chlorocebus sabaeus	65.26	0.00e+00	959.00
IUUC-Cho-024358	Choloepus hoffmanni	49.86	3.00e-87	315.00
IUUC-Cme-027348	Cyanidioschyzon merolae	36.13	2.00e-19	90.90
IUUC-Dre-028106	Danio rerio	54.30	0.00e+00	848.00
IUUC-Dno-029456	Dasypus novemcinctus	62.43	2.00e-163	568.00
IUUC-Dor-030438	Dipodomys ordii	52.43	0.00e+00	736.00
IUUC-Dme-031870	Drosophila melanogaster	47.40	3.00e-34	140.00
IUUC-Ete-032736	Echinops telfairi	54.92	0.00e+00	794.00
IUUC-Eca-034211	Equus caballus	67.43	0.00e+00	1056.00
IUUC-Eeu-034797	Erinaceus europaeus	69.74	1.00e-78	287.00
IUUC-Fca-035947	Felis catus	65.53	0.00e+00	940.00
IUUC-Fal-037199	Ficedula albicollis	82.35	0.00e+00	1157.00
IUUC-Gmo-039228	Gadus morhua	65.15	2.00e-150	525.00
IUUC-Gga-040823	Gallus gallus	78.32	0.00e+00	747.00
IUUC-Gac-042406	Gasterosteus aculeatus	63.55	7.00e-147	514.00
IUUC-Ggo-045402	Gorilla gorilla	65.58	0.00e+00	1038.00
IUUC-Hsa-046430	Homo sapiens	65.78	0.00e+00	1043.00
IUUC-Itr-048855	Ictidomys tridecemlineatus	65.69	3.00e-168	584.00
IUUC-Lch-049547	Latimeria chalumnae	63.93	0.00e+00	996.00
IUUC-Loc-052842	Lepisosteus oculatus	61.29	0.00e+00	955.00
IUUC-Laf-053988	Loxodonta africana	66.95	0.00e+00	1054.00
IUUC-Mcc-055491	Macaca mulatta	63.35	0.00e+00	991.00
IUUC-Meu-056256	Macropus eugenii	67.28	0.00e+00	648.00
IUUC-Mtr-057945	Medicago truncatula	31.79	6.00e-33	136.00
IUUC-Mla-059026	Melampsora laricipopulina	32.20	7.00e-19	88.60
IUUC-Mga-059833	Meleagris gallopavo	74.59	0.00e+00	761.00
IUUC-Mmr-060952	Microcebus murinus	66.30	0.00e+00	1028.00
IUUC-Mdo-062642	Monodelphis domestica	73.85	0.00e+00	1142.00
IUUC-Mmu-063945	Mus musculus	63.27	0.00e+00	1012.00
IUUC-Mac-064941	Musa acuminata	28.68	4.00e-55	209.00
IUUC-Mpu-065944	Mustela putorius furo	62.74	0.00e+00	975.00
IUUC-Mlu-067049	Myotis lucifugus	64.77	0.00e+00	990.00
IUUC-Nle-069828	Nomascus leucogenys	66.42	0.00e+00	1053.00
IUUC-Opr-070672	Ochotona princeps	60.00	1.00e-117	417.00
IUUC-Ont-072121	Oreochromis niloticus	63.61	2.00e-147	516.00
IUUC-Oan-073656	Ornithorhynchus anatinus	68.19	0.00e+00	1125.00
IUUC-Ocu-074323	Oryctolagus cuniculus	65.38	0.00e+00	1008.00
IUUC-Ola-087238	Oryzias latipes	56.02	0.00e+00	834.00
IUUC-Oga-088379	Otolemur garnettii	63.54	0.00e+00	968.00
IUUC-Oar-089718	Ovis aries	66.95	0.00e+00	1024.00
IUUC-Ptr-091358	Pan troglodytes	65.53	0.00e+00	1042.00
IUUC-Pan-092023	Papio anubis	65.90	0.00e+00	1033.00
IUUC-Pfo-097285	Poecilia formosa	56.46	2.00e-125	443.00
IUUC-Pab-098539	Pongo abelii	65.78	0.00e+00	1046.00
IUUC-Pca-100610	Procavia capensis	55.95	0.00e+00	741.00
IUUC-Pva-102985	Pteropus vampyrus	73.39	2.00e-166	579.00
IUUC-Rno-105538	Rattus norvegicus	63.08	0.00e+00	1008.00
IUUC-Sha-107022	Sarcophilus harrisii	63.99	0.00e+00	1014.00
IUUC-Sja-107712	Schizosaccharomyces japonicus	27.59	2.00e-19	90.90
IUUC-Spo-108149	Schizosaccharomyces pombe	29.41	3.00e-21	97.10
IUUC-Sar-113637	Sorex araneus	66.11	0.00e+00	637.00
IUUC-Ssc-115870	Sus scrofa	67.07	0.00e+00	1065.00
IUUC-Tgu-116907	Taeniopygia guttata	80.95	0.00e+00	1315.00
IUUC-Tru-117835	Takifugu rubripes	56.19	9.00e-113	400.00
IUUC-Tsy-118869	Tarsius syrichta	66.58	0.00e+00	909.00
IUUC-Tni-119716	Tetraodon nigroviridis	60.33	1.00e-99	356.00
IUUC-Tbe-128041	Tupaia belangeri	56.81	0.00e+00	696.00
IUUC-Ttr-128901	Tursiops truncatus	63.27	0.00e+00	974.00
IUUC-Vpa-130331	Vicugna pacos	66.71	0.00e+00	949.00
IUUC-Xtr-131794	Xenopus tropicalis	55.69	0.00e+00	836.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence