iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000068328.9	ENSMUST00000092618.8	ENSMUSP00000090281.6
ENSMUSG00000068328.9	ENSMUST00000203915.2	ENSMUSP00000145020.1
ENSMUSG00000068328.9	ENSMUST00000204719.2	ENSMUSP00000145409.1
ENSMUSG00000068328.9	ENSMUST00000204343.2	ENSMUSP00000145335.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	miRNAMap
RAID2
Protein-protein Interaction
IID	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/CUE	CUE	21127063; 21857022

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/CUE	3.30e-11	44.0	325	366

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 1    dletaleqLkeiFPnldysviqvvLeantgsleaavnnLLegs 43
           +l+t+++++ke++P+++  viq++L a+tg+++ +++nLLeg+
   Q: 325  QLTTLAHRVKEVLPHVPLNVIQRDL-ARTGCVDLTITNLLEGA 366
           689**********************.***************96 PP

Organism

Mus musculus

Functional Description
(View)

May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome.

Protein Sequence
(Fasta)

MPKDSAFPGA PAALRRWRRQ RPRSPEAAAM EPPPAPGPER LFDSHRLPSD GFLLLALLLY 60
APVGLCLLVL RLFLGLHVFL VSCALPDSVL RRFVVRTMCA VLGLVARQED SGLRDHRVRV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTCAGCGCA TGCCGGGAAA CGTAGTCCCG TCAGGACGCG CTCCTCTCCA GCATACGCAC 60
ACGCTCACAC ACAAACACAC ACACATACAC ACACATTCCC CGGGGCCGCG AGGCATGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway

Interpro

IPR003892--CUE

PROSITE

PS51140--CUE

Pfam

PF02845--CUE

SMART

SM00546--CUE

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0000839--C:Hrd1p ubiquitin ligase ERAD-L complex
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0016020--C:membrane
GO:0043130--F:ubiquitin binding
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0030970--P:retrograde protein transport, ER to cytosol
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000658	Aegilops tauschii	48.15	4.50e-02	31.20
IUUC-Aml-002330	Ailuropoda melanoleuca	91.67	3.00e-169	587.00
IUUC-Apl-003946	Anas platyrhynchos	55.87	2.00e-102	365.00
IUUC-Aca-004676	Anolis carolinensis	54.17	1.00e-25	108.00
IUUC-Ago-007976	Ashbya gossypii	36.36	3.70e-01	27.70
IUUC-Bta-012397	Bos taurus	91.50	0.00e+00	650.00
IUUC-Bdi-014890	Brachypodium distachyon	32.69	3.00e-05	43.50
IUUC-Cel-018644	Caenorhabditis elegans	34.53	9.00e-36	144.00
IUUC-Cja-018775	Callithrix jacchus	75.27	6.00e-161	560.00
IUUC-Cfa-020710	Canis familiaris	91.91	6.00e-177	613.00
IUUC-Cpo-022111	Cavia porcellus	91.75	0.00e+00	655.00
IUUC-Csa-023411	Chlorocebus sabaeus	91.50	0.00e+00	643.00
IUUC-Cin-025458	Ciona intestinalis	36.27	1.00e-12	64.30
IUUC-Dre-027938	Danio rerio	52.53	1.00e-109	389.00
IUUC-Dno-028873	Dasypus novemcinctus	90.00	0.00e+00	629.00
IUUC-Dor-030537	Dipodomys ordii	80.60	3.00e-168	584.00
IUUC-Ete-032422	Echinops telfairi	65.07	9.00e-131	460.00
IUUC-Eca-033757	Equus caballus	90.00	0.00e+00	631.00
IUUC-Eeu-034556	Erinaceus europaeus	72.61	2.00e-161	561.00
IUUC-Fca-035438	Felis catus	91.75	0.00e+00	649.00
IUUC-Fal-036911	Ficedula albicollis	52.43	3.00e-95	342.00
IUUC-Gmo-039147	Gadus morhua	50.49	4.00e-96	345.00
IUUC-Gga-041239	Gallus gallus	58.51	2.00e-108	385.00
IUUC-Gac-041814	Gasterosteus aculeatus	49.51	5.00e-98	351.00
IUUC-Ggo-044745	Gorilla gorilla	88.96	1.00e-136	479.00
IUUC-Hsa-046167	Homo sapiens	90.75	0.00e+00	639.00
IUUC-Itr-048661	Ictidomys tridecemlineatus	92.69	0.00e+00	626.00
IUUC-Lch-050576	Latimeria chalumnae	51.81	6.00e-97	347.00
IUUC-Lpe-051312	Leersia perrieri	31.07	7.00e-03	35.40
IUUC-Loc-052028	Lepisosteus oculatus	54.35	5.00e-105	374.00
IUUC-Laf-053886	Loxodonta africana	89.50	8.00e-177	613.00
IUUC-Mcc-055399	Macaca mulatta	86.50	9.00e-167	579.00
IUUC-Meu-056355	Macropus eugenii	58.51	2.00e-111	395.00
IUUC-Mga-060065	Meleagris gallopavo	54.39	1.00e-94	339.00
IUUC-Mpu-066233	Mustela putorius furo	92.00	0.00e+00	649.00
IUUC-Mlu-067489	Myotis lucifugus	90.75	0.00e+00	638.00
IUUC-Nle-070040	Nomascus leucogenys	89.30	5.00e-138	484.00
IUUC-Ont-071616	Oreochromis niloticus	50.12	8.00e-100	357.00
IUUC-Ocu-074618	Oryctolagus cuniculus	91.75	0.00e+00	656.00
IUUC-Ogl-077799	Oryza glaberrima	32.38	2.80e-02	33.90
IUUC-Ola-086583	Oryzias latipes	41.85	8.00e-82	297.00
IUUC-Oga-089100	Otolemur garnettii	88.33	0.00e+00	649.00
IUUC-Oar-089813	Ovis aries	91.25	0.00e+00	648.00
IUUC-Ptr-091436	Pan troglodytes	91.00	0.00e+00	639.00
IUUC-Pan-092755	Papio anubis	91.25	0.00e+00	643.00
IUUC-Psi-093736	Pelodiscus sinensis	70.43	5.00e-54	203.00
IUUC-Pma-094429	Petromyzon marinus	50.55	2.00e-89	322.00
IUUC-Pfo-097015	Poecilia formosa	47.68	2.00e-92	332.00
IUUC-Pab-098382	Pongo abelii	91.25	0.00e+00	641.00
IUUC-Pca-100900	Procavia capensis	82.09	5.00e-80	291.00
IUUC-Pva-103248	Pteropus vampyrus	70.41	6.00e-142	497.00
IUUC-Rno-105755	Rattus norvegicus	98.16	6.00e-174	603.00
IUUC-Sha-107434	Sarcophilus harrisii	77.14	9.00e-103	366.00
IUUC-Stu-112774	Solanum tuberosum	28.97	5.00e-03	36.20
IUUC-Sar-113104	Sorex araneus	70.03	4.00e-95	340.00
IUUC-Sre-115215	Sporisorium reilianum	37.50	5.60e-02	31.20
IUUC-Ssc-116047	Sus scrofa	88.01	1.00e-163	568.00
IUUC-Tgu-117436	Taeniopygia guttata	56.49	5.00e-104	371.00
IUUC-Tru-118227	Takifugu rubripes	47.62	4.00e-94	338.00
IUUC-Tni-120873	Tetraodon nigroviridis	48.29	8.00e-96	343.00
IUUC-Ttr-128895	Tursiops truncatus	74.57	2.00e-161	561.00
IUUC-Xtr-131917	Xenopus tropicalis	56.00	7.00e-56	210.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence