iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-022382

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02047570

Gene Name

HECTD1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000013566.3	ENSCPOT00000013701.2	ENSCPOP00000012213.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.50e-124	415.0	2147	2605

Active Site

Position(s)	Description	Evidence
2574	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysen..dketlqpnpdsglknp..................... 65
           ++d+k++levef+gEeg++l G+t+ef+al+++e+q++dlg++l+++n  d+e+++++   g+k+p                     
   Q: 2147 HADRKSVLEVEFLGEEGTGL-GPTLEFYALVAAEFQRTDLGAWLCDDNfpDDESRHVDLGGGVKPPgyyvqrscglftapfpqdsde 2232
           6899****************.******************************************999********************* PP
   S: 66   ..ehlklFeflGrllgkalqdgrlldlplsksfykll.................................................. 100
             + +klF+flG++l+k++qd+rl+dlp+sk+f+kl+                                                  
   Q: 2233 leRITKLFHFLGIFLAKCIQDNRLVDLPISKPFFKLMcmgdiksnmskliyesrgdrdlhctesqseasteeghdslsvgsfeedsk 2319
           *************************************99999999999999999999999999999999999999988888888887 PP
   S: 101  ...............lgkklsledleevdpelykslkeikenaes..................................dieelgld 138
                          ++  l++ed+e v+p+++++lkeik++a +                                  +ie+lgl+
   Q: 2320 sefildppkpkppawFNGILTWEDFELVNPHRARFLKEIKDLAIKrrqilsnkglsedekntklqelvlknpsgsgpplSIEDLGLN 2406
           7777777777766666668***********************9334455555666777788899999999999************** PP
   S: 139  ltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeid 225
           ++f++s++i+g t+++ Lkp+Ge++++t++N+eeYv+l++++++++gi++q+eafr+Gfn+v+p+e+ls+F++ee+++++cG+   +
   Q: 2407 FQFCPSSRIYGFTAVD-LKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAFRDGFNKVFPMEKLSSFSHEEVQMILCGN---Q 2489
           *************999.******************************************************************...6 PP
   S: 226  vedlkket..ky...kggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfn 306
           ++++++e+  +y   k gyt+dsp++ +F++vl+++ss+erkafLqF+Tg+s+lP+gG+a+l+prl+v+rk da+d+++Ps+nTC++
   Q: 2490 SPSWAAEDiiNYtepKLGYTRDSPGFLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRKvDATDASYPSVNTCVH 2576
           666666665555555************************************************************************ PP
   S: 307  yLkLPeYsskeilkekLlyAieetkgFels 336
           yLkLPeYss+ei++e+Ll+A++e kgF+l+
   Q: 2577 YLKLPEYSSEEIMRERLLAATME-KGFHLN 2605
           ***********************.****86 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

MADVDPDTLL EWLQMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFETCPP RTFLPALCKI 60
FLDESAPDNV LEVTARAITY YLDVSAECTR RIVGVDGAIK ALCNRLVVVE LNNRTSRDLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCAGATG TGGATCCAGA TACATTGCTG GAATGGCTAC AGATGGGACA GGGAGATGAA 60
AGGGACATGC AACTAATTGC CCTTGAACAG CTATGTATGC TGCTTTTGAT GTCTGACAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR020683--Ankyrin_rpt-contain_dom
IPR016024--ARM-type_fold
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR012919--SUN_dom

PROSITE

PS50297--ANK_REP_REGION
PS50237--HECT
PS51416--MIB_HERC2

Pfam

PF00632--HECT
PF06701--MIB_HERC2
PF07738--Sad1_UNC

SMART

SM00119--HECTc

Gene Ontology

GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001987	Ailuropoda melanoleuca	95.11	0.00e+00	4411.00
IUUC-Apl-003493	Anas platyrhynchos	91.41	0.00e+00	4259.00
IUUC-Aca-004521	Anolis carolinensis	90.13	0.00e+00	2557.00
IUUC-Ame-011258	Astyanax mexicanus	84.42	0.00e+00	2144.00
IUUC-Bta-012835	Bos taurus	95.07	0.00e+00	4426.00
IUUC-Cel-018153	Caenorhabditis elegans	47.77	2.00e-161	564.00
IUUC-Cja-019174	Callithrix jacchus	94.66	0.00e+00	4364.00
IUUC-Cfa-021115	Canis familiaris	95.03	0.00e+00	4403.00
IUUC-Csa-023230	Chlorocebus sabaeus	95.38	0.00e+00	4425.00
IUUC-Cho-024711	Choloepus hoffmanni	96.15	0.00e+00	1646.00
IUUC-Cin-025342	Ciona intestinalis	49.67	0.00e+00	1212.00
IUUC-Csv-026031	Ciona savignyi	48.04	0.00e+00	1242.00
IUUC-Dre-027435	Danio rerio	83.26	0.00e+00	3868.00
IUUC-Dno-029954	Dasypus novemcinctus	95.04	0.00e+00	4385.00
IUUC-Dor-030734	Dipodomys ordii	97.96	0.00e+00	1503.00
IUUC-Dme-031739	Drosophila melanogaster	55.95	0.00e+00	1454.00
IUUC-Ete-033192	Echinops telfairi	80.72	1.00e-151	530.00
IUUC-Eca-033434	Equus caballus	95.00	0.00e+00	4409.00
IUUC-Eeu-035031	Erinaceus europaeus	97.81	4.00e-146	511.00
IUUC-Fca-035998	Felis catus	93.59	0.00e+00	4303.00
IUUC-Fal-037468	Ficedula albicollis	89.33	0.00e+00	2562.00
IUUC-Gmo-038495	Gadus morhua	80.64	0.00e+00	1154.00
IUUC-Gga-040736	Gallus gallus	90.90	0.00e+00	2567.00
IUUC-Gac-041777	Gasterosteus aculeatus	84.84	0.00e+00	2177.00
IUUC-Ggo-044677	Gorilla gorilla	91.77	0.00e+00	4191.00
IUUC-Hsa-045879	Homo sapiens	95.38	0.00e+00	4425.00
IUUC-Itr-048664	Ictidomys tridecemlineatus	95.19	0.00e+00	4425.00
IUUC-Lch-050444	Latimeria chalumnae	88.06	0.00e+00	3950.00
IUUC-Loc-051986	Lepisosteus oculatus	84.32	0.00e+00	3915.00
IUUC-Laf-054230	Loxodonta africana	94.86	0.00e+00	4350.00
IUUC-Mcc-054787	Macaca mulatta	95.38	0.00e+00	4425.00
IUUC-Meu-056502	Macropus eugenii	89.02	0.00e+00	1330.00
IUUC-Mga-059409	Meleagris gallopavo	90.85	0.00e+00	2074.00
IUUC-Mmr-061667	Microcebus murinus	94.64	0.00e+00	4402.00
IUUC-Mdo-061960	Monodelphis domestica	93.55	0.00e+00	4349.00
IUUC-Mmu-063941	Mus musculus	94.37	0.00e+00	4370.00
IUUC-Mpu-065939	Mustela putorius furo	95.04	0.00e+00	4413.00
IUUC-Mlu-068112	Myotis lucifugus	94.73	0.00e+00	4374.00
IUUC-Nle-069001	Nomascus leucogenys	95.30	0.00e+00	4422.00
IUUC-Opr-071222	Ochotona princeps	86.09	0.00e+00	1869.00
IUUC-Ont-072101	Oreochromis niloticus	77.55	0.00e+00	3682.00
IUUC-Oan-072814	Ornithorhynchus anatinus	93.39	0.00e+00	4319.00
IUUC-Ocu-074011	Oryctolagus cuniculus	95.19	0.00e+00	4418.00
IUUC-Ola-086412	Oryzias latipes	84.50	0.00e+00	2166.00
IUUC-Oar-089668	Ovis aries	95.15	0.00e+00	4420.00
IUUC-Ptr-090517	Pan troglodytes	95.27	0.00e+00	4399.00
IUUC-Pan-091849	Papio anubis	94.47	0.00e+00	4358.00
IUUC-Psi-093390	Pelodiscus sinensis	87.75	0.00e+00	2472.00
IUUC-Pma-094628	Petromyzon marinus	80.69	0.00e+00	1522.00
IUUC-Pfo-097075	Poecilia formosa	84.94	0.00e+00	2202.00
IUUC-Pab-098176	Pongo abelii	95.38	0.00e+00	4425.00
IUUC-Pca-101123	Procavia capensis	93.71	0.00e+00	2482.00
IUUC-Pva-103008	Pteropus vampyrus	94.42	0.00e+00	1914.00
IUUC-Rno-105885	Rattus norvegicus	94.58	0.00e+00	4385.00
IUUC-Sha-107048	Sarcophilus harrisii	91.83	0.00e+00	4259.00
IUUC-Sar-113071	Sorex araneus	86.92	0.00e+00	1132.00
IUUC-Ssc-115963	Sus scrofa	94.73	0.00e+00	4395.00
IUUC-Tgu-117167	Taeniopygia guttata	93.67	0.00e+00	2615.00
IUUC-Tru-118626	Takifugu rubripes	85.85	0.00e+00	2250.00
IUUC-Tsy-119504	Tarsius syrichta	94.08	0.00e+00	2211.00
IUUC-Tni-119877	Tetraodon nigroviridis	85.18	0.00e+00	2194.00
IUUC-Tbe-127602	Tupaia belangeri	81.60	0.00e+00	782.00
IUUC-Ttr-128394	Tursiops truncatus	98.37	0.00e+00	3144.00
IUUC-Vpa-130280	Vicugna pacos	94.39	0.00e+00	4200.00
IUUC-Xtr-131787	Xenopus tropicalis	80.66	0.00e+00	2362.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence