iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000143756.11	ENST00000366862.9	ENSP00000355827.5
ENSG00000143756.11	ENST00000424254.6	ENSP00000416888.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
miRecords	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Information
GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	23776131

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	0.00028	22.6	25	99

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 54   asrrtprqpprgpsaaakpkaglrseaaaapapapaptptpeegpdaglldrlpeeilveilklldkeellraarvcrrwqelas 138
           as  t rqpp  p a  +p+ g      a papa a    p++ p++++l  lp   + +il++++ +e+ ++++vc+r+  +++
   Q: 25   ASGSTQRQPP--PPAPQHPQPGS----QALPAPALA----PDQLPQNNTLVALPIVAIENILSFMSYDEISQLRLVCKRMDLVCQ 99
           6778888888..77788888873....355666665....56667788999*****************************97776 PP

Organism

Homo sapiens

Functional Description
(View)

Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.

Protein Sequence
(Fasta)

MAAAAEERMA EEGGGGQGDG GSSLASGSTQ RQPPPPAPQH PQPGSQALPA PALAPDQLPQ 60
NNTLVALPIV AIENILSFMS YDEISQLRLV CKRMDLVCQR MLNQGFLKVE RYHNLCQKQV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCTGTTCCC CTTGCTGTGG GGGTAAGGAA TCAAGCCCCC AAGATGGCGG CAGCGGCGGA 60
GGAGCGGATG GCAGAGGAAG GAGGCGGCGG CCAAGGCGAC GGCGGTTCCT CTTTGGCCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0137--Centromere
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0995--Kinetochore
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR001810--F-box_dom

PROSITE

PS50181--FBOX

Pfam

PF00646--F-box

Gene Ontology

GO:0000777--C:condensed chromosome kinetochore
GO:0000776--C:kinetochore

KEGG

hsa:23219

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001643	Ailuropoda melanoleuca	97.00	4.00e-161	560.00
IUUC-Apl-003253	Anas platyrhynchos	94.98	7.00e-140	489.00
IUUC-Aca-004567	Anolis carolinensis	94.78	5.00e-63	233.00
IUUC-Ate-010552	Aspergillus terreus	31.91	1.20e-02	35.80
IUUC-Ame-011558	Astyanax mexicanus	84.47	7.00e-121	427.00
IUUC-Bta-013374	Bos taurus	99.32	6.00e-156	543.00
IUUC-Cel-018423	Caenorhabditis elegans	21.95	4.00e-03	37.00
IUUC-Cja-019723	Callithrix jacchus	99.03	1.00e-159	555.00
IUUC-Cfa-020187	Canis familiaris	98.99	1.00e-151	529.00
IUUC-Cpo-021654	Cavia porcellus	96.84	1.00e-168	585.00
IUUC-Cre-022826	Chlamydomonas reinhardtii	31.94	9.00e-03	37.00
IUUC-Csa-024022	Chlorocebus sabaeus	99.38	2.00e-170	591.00
IUUC-Cho-024424	Choloepus hoffmanni	90.29	8.00e-144	503.00
IUUC-Cin-025692	Ciona intestinalis	42.42	2.00e-38	152.00
IUUC-Csv-026080	Ciona savignyi	42.17	1.00e-34	140.00
IUUC-Cgl-026698	Colletotrichum gloeosporioides	33.33	9.20e-01	28.10
IUUC-Dre-028588	Danio rerio	76.57	7.00e-120	423.00
IUUC-Dno-029117	Dasypus novemcinctus	99.32	5.00e-156	543.00
IUUC-Dor-031090	Dipodomys ordii	98.72	2.00e-158	551.00
IUUC-Dme-031989	Drosophila melanogaster	53.29	6.00e-46	177.00
IUUC-Ete-032337	Echinops telfairi	92.26	1.00e-145	509.00
IUUC-Eca-033767	Equus caballus	99.34	1.00e-156	545.00
IUUC-Eeu-035177	Erinaceus europaeus	98.88	1.00e-144	505.00
IUUC-Fca-036035	Felis catus	96.43	9.00e-133	466.00
IUUC-Fal-037596	Ficedula albicollis	91.76	2.00e-140	491.00
IUUC-Gmo-038626	Gadus morhua	81.61	5.00e-108	384.00
IUUC-Gga-041259	Gallus gallus	93.81	7.00e-154	536.00
IUUC-Gac-042395	Gasterosteus aculeatus	74.92	3.00e-126	444.00
IUUC-Gma-043619	Glycine max	29.82	2.10e-02	30.00
IUUC-Ggo-045281	Gorilla gorilla	79.06	1.00e-97	350.00
IUUC-Itr-048750	Ictidomys tridecemlineatus	98.92	2.00e-142	498.00
IUUC-Kpa-049140	Komagataella pastoris	25.00	3.00e-04	40.00
IUUC-Lch-049411	Latimeria chalumnae	85.67	5.00e-143	500.00
IUUC-Loc-052291	Lepisosteus oculatus	79.50	2.00e-131	461.00
IUUC-Laf-053345	Loxodonta africana	98.65	4.00e-158	550.00
IUUC-Mcc-055319	Macaca mulatta	100.00	1.00e-154	539.00
IUUC-Meu-056588	Macropus eugenii	87.95	1.00e-139	489.00
IUUC-Mtr-057635	Medicago truncatula	37.74	5.20e-02	34.30
IUUC-Mga-059617	Meleagris gallopavo	89.00	2.00e-141	494.00
IUUC-Mmr-060648	Microcebus murinus	98.38	3.00e-157	547.00
IUUC-Mdo-062884	Monodelphis domestica	97.07	1.00e-156	545.00
IUUC-Mmu-063401	Mus musculus	98.01	5.00e-157	546.00
IUUC-Mpu-065851	Mustela putorius furo	99.32	2.00e-162	564.00
IUUC-Mlu-068195	Myotis lucifugus	98.50	3.00e-143	501.00
IUUC-Nle-069203	Nomascus leucogenys	99.68	1.00e-164	572.00
IUUC-Opr-070448	Ochotona princeps	93.98	6.00e-141	493.00
IUUC-Ont-071937	Oreochromis niloticus	75.62	2.00e-129	455.00
IUUC-Oan-073133	Ornithorhynchus anatinus	97.97	1.00e-155	542.00
IUUC-Ocu-073883	Oryctolagus cuniculus	99.66	7.00e-154	536.00
IUUC-Ola-087506	Oryzias latipes	75.08	6.00e-124	437.00
IUUC-Oga-088778	Otolemur garnettii	99.66	2.00e-156	545.00
IUUC-Oar-089482	Ovis aries	87.38	5.00e-139	487.00
IUUC-Ptr-090499	Pan troglodytes	100.00	1.00e-154	539.00
IUUC-Pan-091794	Papio anubis	100.00	2.00e-84	304.00
IUUC-Psi-093843	Pelodiscus sinensis	96.11	2.00e-137	481.00
IUUC-Pfo-096172	Poecilia formosa	82.12	8.00e-121	426.00
IUUC-Pab-098536	Pongo abelii	100.00	1.00e-154	539.00
IUUC-Pca-100276	Procavia capensis	84.03	6.00e-130	456.00
IUUC-Pva-102517	Pteropus vampyrus	98.36	1.00e-165	575.00
IUUC-Pgr-103422	Puccinia graminis	30.95	5.00e-03	35.40
IUUC-Rno-104911	Rattus norvegicus	98.67	8.00e-158	549.00
IUUC-Sha-107380	Sarcophilus harrisii	89.49	1.00e-142	499.00
IUUC-Sar-112981	Sorex araneus	97.00	4.00e-141	493.00
IUUC-Ssc-115642	Sus scrofa	98.99	4.00e-156	543.00
IUUC-Tgu-117114	Taeniopygia guttata	90.94	5.00e-150	523.00
IUUC-Tru-118076	Takifugu rubripes	75.62	1.00e-126	445.00
IUUC-Tsy-119060	Tarsius syrichta	100.00	2.00e-137	481.00
IUUC-Tni-119916	Tetraodon nigroviridis	85.11	8.00e-44	167.00
IUUC-Tae-122918	Triticum aestivum	25.69	4.00e-03	35.00
IUUC-Tbe-128023	Tupaia belangeri	98.98	1.00e-88	320.00
IUUC-Ttr-128756	Tursiops truncatus	99.34	3.00e-167	581.00
IUUC-Vpa-130447	Vicugna pacos	99.34	2.00e-167	581.00
IUUC-Xtr-132156	Xenopus tropicalis	79.31	6.00e-127	447.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence