iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

   S: 5    eflCpIslelMrdPvvlpsGitydrssIekwlasggk.tcPvtrqplteedlvPnltlrrliqaw 68
            f C++ le+ ++Pv + +G+++ rs+I+  +++++k tcP +r+ l +e +      +r+ +++
   Q: 34   SFDCSVCLEVLHHPVRTRCGHVFCRSCIATSIKNNNKwTCPYCRAYLPSEGVPATDIAKRMKSEY 98
           79******************************999999*********999988888888888877 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C++Cle + + p+ ++CgHvf+++C+       + + +++++CP+Cr
   Q: 37   CSVCLEVLHH-PVRTRCGHVFCRSCIaT-----SIKNNNKWTCPYCR 77
           ********99.777***********943.....3579*********8 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MGSLLSSDSS KSAPTSSARR TLERSGDPEL PITSFDCSVC LEVLHHPVRT RCGHVFCRSC 60
IATSIKNNNK WTCPYCRAYL PSEGVPATDI AKRMKSEYQN CTECGTLVCL SDMRAHIRTC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGAGAGGCCC CGCGCCGCGG CTGGCCGATC CAGGAGGCGG CGATCCGGGC TGGGCCGGGA 60
CTTCCTTCCT CCCGGGCGGG ACAACAGAAC CACCAGCAGC CCGCTCGGAG CTCCCGGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008598--Di19_Zn_binding_dom
IPR034734--ZF_C2HC_RNF
IPR027370--Znf-RING_LisH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51803--ZF_C2HC_RNF
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF05605--zf-Di19
PF13445--zf-RING_UBOX

SMART

SM00184--RING

Gene Ontology

GO:0000139--C:Golgi membrane
GO:0005622--C:intracellular
GO:0034098--C:VCP-NPL4-UFD1 AAA ATPase complex
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0039536--P:negative regulation of RIG-I signaling pathway
GO:0032480--P:negative regulation of type I interferon production
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001992	Ailuropoda melanoleuca	85.84	6.00e-114	402.00
IUUC-Aca-004839	Anolis carolinensis	62.78	5.00e-65	239.00
IUUC-Bta-012827	Bos taurus	84.55	1.00e-111	395.00
IUUC-Cja-018794	Callithrix jacchus	85.41	3.00e-112	397.00
IUUC-Cfa-021234	Canis familiaris	88.21	1.00e-110	391.00
IUUC-Cpo-022412	Cavia porcellus	81.00	1.00e-96	345.00
IUUC-Csa-023406	Chlorocebus sabaeus	86.27	1.00e-113	402.00
IUUC-Cho-024427	Choloepus hoffmanni	73.03	1.00e-70	258.00
IUUC-Dno-030085	Dasypus novemcinctus	83.69	9.00e-111	392.00
IUUC-Dor-030911	Dipodomys ordii	66.09	1.00e-63	236.00
IUUC-Ete-032469	Echinops telfairi	82.40	3.00e-108	384.00
IUUC-Eca-034352	Equus caballus	85.41	5.00e-113	400.00
IUUC-Eeu-034889	Erinaceus europaeus	71.67	4.00e-88	317.00
IUUC-Fca-036116	Felis catus	86.45	8.00e-110	389.00
IUUC-Hsa-046518	Homo sapiens	84.98	7.00e-112	395.00
IUUC-Itr-048344	Ictidomys tridecemlineatus	89.33	7.00e-93	332.00
IUUC-Laf-053363	Loxodonta africana	84.68	3.00e-111	394.00
IUUC-Meu-056101	Macropus eugenii	77.40	6.00e-92	329.00
IUUC-Mdo-062046	Monodelphis domestica	78.05	6.00e-94	336.00
IUUC-Mmu-063184	Mus musculus	95.71	1.00e-66	244.00
IUUC-Mpu-065708	Mustela putorius furo	85.41	2.00e-112	397.00
IUUC-Mlu-067561	Myotis lucifugus	83.71	9.00e-88	315.00
IUUC-Nle-069665	Nomascus leucogenys	83.72	7.00e-101	359.00
IUUC-Opr-070301	Ochotona princeps	73.39	5.00e-92	330.00
IUUC-Ocu-074562	Oryctolagus cuniculus	84.92	8.00e-61	224.00
IUUC-Oga-088958	Otolemur garnettii	86.27	2.00e-113	401.00
IUUC-Oar-089541	Ovis aries	85.96	4.00e-90	323.00
IUUC-Ptr-090989	Pan troglodytes	85.41	7.00e-113	399.00
IUUC-Pan-092372	Papio anubis	85.84	2.00e-113	401.00
IUUC-Pab-098718	Pongo abelii	72.96	3.00e-89	320.00
IUUC-Pca-100453	Procavia capensis	84.12	3.00e-110	390.00
IUUC-Pva-102931	Pteropus vampyrus	84.55	1.00e-104	372.00
IUUC-Sha-107557	Sarcophilus harrisii	71.79	1.00e-94	339.00
IUUC-Sar-113435	Sorex araneus	84.92	2.00e-61	226.00
IUUC-Ssc-116388	Sus scrofa	84.98	1.00e-113	401.00
IUUC-Tsy-119439	Tarsius syrichta	88.20	2.00e-92	330.00
IUUC-Tbe-127417	Tupaia belangeri	63.16	8.00e-62	229.00
IUUC-Ttr-129212	Tursiops truncatus	85.41	1.00e-113	401.00
IUUC-Vpa-130153	Vicugna pacos	85.84	3.00e-113	400.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence