iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012808

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase RNF126; RING finger protein 126

Genbank Nucleotide ID

BC122844

Gene Name

RNF126

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000014349.4	ENSBTAT00000019080.4	ENSBTAP00000019080.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	9.00e-09	35.9	232	273

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++C++d+   ++++ lpC+H+fh  C+  w        ++++CP+Cr
   Q: 232  CPVCKDDYglGEHVRQLPCNHLFHDGCIVPW------LEQHDSCPVCR 273
           ********99555******************......**********8 PP

Organism

Bos taurus

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins. Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates. Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome. May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor. May play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4, by mediating their ubiquitination. By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation. May monoubiquitinate AICDA.

Protein Sequence
(Fasta)

MAEASPQPGR YFCHCCSVEI VPRLPDYICP RCESGFIEEL PEETRSAENG SAPSTASADQ 60
SRQQPFENVD QPLFTLPQGY GHFAFGIFDD SFEIPTFPPG AQADDSRDPE SRREREQHSR 120

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Nucleotide Sequence
(Fasta)

CGTCGGCCGG CGAGGGAGCA GCAAACGGCC GGCGGCGGGC GCCGCGCGGG GGGCGGGCGG 60
CGCGGAGGAG GCGGCGGTGG CCATGGCCGA GGCGTCGCCG CAGCCCGGAC GGTACTTCTG 120

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Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0042127--P:regulation of cell proliferation
GO:0042147--P:retrograde transport, endosome to Golgi
GO:0071629--P:ubiquitin-dependent catabolism of misfolded proteins by cytoplasm-associated proteasome
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

KEGG

bta:507447

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000551	Aegilops tauschii	46.73	1.00e-24	106.00
IUUC-Aml-002001	Ailuropoda melanoleuca	92.36	5.00e-142	496.00
IUUC-Atr-002522	Amborella trichopoda	50.53	4.00e-27	114.00
IUUC-Apl-003778	Anas platyrhynchos	77.69	4.00e-95	340.00
IUUC-Aca-005166	Anolis carolinensis	77.78	2.00e-107	381.00
IUUC-Ath-007616	Arabidopsis thaliana	31.48	2.00e-28	119.00
IUUC-Afl-008423	Aspergillus flavus	43.00	9.00e-18	84.70
IUUC-Afu-008920	Aspergillus fumigatus	43.43	7.00e-17	81.60
IUUC-Ani-009396	Aspergillus nidulans	41.84	2.00e-16	80.50
IUUC-Ang-009638	Aspergillus niger	45.19	3.00e-17	82.40
IUUC-Aor-009896	Aspergillus oryzae	43.00	1.00e-17	84.30
IUUC-Ame-010626	Astyanax mexicanus	72.51	2.00e-116	411.00
IUUC-Bgr-012144	Blumeria graminis	35.38	2.00e-18	87.40
IUUC-Bdi-014137	Brachypodium distachyon	48.18	6.00e-26	111.00
IUUC-Cel-018216	Caenorhabditis elegans	44.93	2.00e-14	72.80
IUUC-Cja-019575	Callithrix jacchus	87.03	7.00e-128	449.00
IUUC-Cfa-020142	Canis familiaris	92.91	6.00e-126	443.00
IUUC-Cpo-022451	Cavia porcellus	92.61	8.00e-139	486.00
IUUC-Csa-023433	Chlorocebus sabaeus	91.75	1.00e-155	541.00
IUUC-Cgl-026759	Colletotrichum gloeosporioides	37.37	1.00e-16	81.60
IUUC-Cme-027122	Cyanidioschyzon merolae	50.00	1.00e-12	68.20
IUUC-Dre-027400	Danio rerio	72.85	1.00e-114	405.00
IUUC-Dno-029349	Dasypus novemcinctus	90.36	9.00e-106	376.00
IUUC-Dor-030103	Dipodomys ordii	93.98	2.00e-120	425.00
IUUC-Eca-034240	Equus caballus	94.22	8.00e-106	375.00
IUUC-Fal-037027	Ficedula albicollis	80.97	2.00e-102	364.00
IUUC-Fox-037736	Fusarium oxysporum	31.25	2.00e-14	73.60
IUUC-Fso-038447	Fusarium solani	37.50	6.00e-16	79.00
IUUC-Gmo-039694	Gadus morhua	71.81	3.00e-123	434.00
IUUC-Gga-040682	Gallus gallus	82.13	3.00e-123	434.00
IUUC-Gac-041364	Gasterosteus aculeatus	69.18	2.00e-112	398.00
IUUC-Ggo-045421	Gorilla gorilla	90.41	4.00e-130	457.00
IUUC-Hsa-046723	Homo sapiens	92.44	3.00e-146	510.00
IUUC-Itr-048435	Ictidomys tridecemlineatus	94.78	1.00e-125	442.00
IUUC-Lch-050071	Latimeria chalumnae	80.28	3.00e-123	434.00
IUUC-Lpe-051427	Leersia perrieri	49.09	2.00e-26	112.00
IUUC-Loc-052470	Lepisosteus oculatus	61.17	7.00e-89	320.00
IUUC-Lma-053066	Leptosphaeria maculans	45.00	1.00e-21	97.80
IUUC-Laf-054249	Loxodonta africana	68.97	1.00e-65	242.00
IUUC-Mcc-055739	Macaca mulatta	92.44	1.00e-146	511.00
IUUC-Mtr-057711	Medicago truncatula	41.35	9.00e-24	103.00
IUUC-Mga-059349	Meleagris gallopavo	78.01	3.00e-110	391.00
IUUC-Mvi-060434	Microbotryum violaceum	36.36	1.00e-18	87.80
IUUC-Mmr-060653	Microcebus murinus	93.31	1.00e-152	531.00
IUUC-Mdo-062442	Monodelphis domestica	87.63	2.00e-142	498.00
IUUC-Mmu-064148	Mus musculus	92.10	1.00e-140	492.00
IUUC-Mpu-065917	Mustela putorius furo	89.44	7.00e-128	449.00
IUUC-Mlu-067495	Myotis lucifugus	93.47	5.00e-142	496.00
IUUC-Nfi-068352	Neosartorya fischeri	43.43	4.00e-17	82.40
IUUC-Nle-069274	Nomascus leucogenys	92.44	7.00e-138	483.00
IUUC-Opr-070359	Ochotona princeps	85.29	2.00e-93	334.00
IUUC-Ont-071505	Oreochromis niloticus	75.00	2.00e-119	422.00
IUUC-Oan-073225	Ornithorhynchus anatinus	79.70	2.00e-111	395.00
IUUC-Oba-075047	Oryza barthii	50.00	5.00e-27	114.00
IUUC-Obr-076829	Oryza brachyantha	51.82	9.00e-28	117.00
IUUC-Ogl-077378	Oryza glaberrima	50.00	6.00e-27	114.00
IUUC-Ogu-078709	Oryza glumaepatula	50.00	5.00e-27	114.00
IUUC-Oin-079400	Oryza indica	49.45	5.00e-23	101.00
IUUC-Olo-080762	Oryza longistaminata	50.00	5.00e-27	114.00
IUUC-Oni-083090	Oryza nivara	50.00	5.00e-27	114.00
IUUC-Opu-083898	Oryza punctata	51.92	1.00e-26	113.00
IUUC-Oru-084267	Oryza rufipogon	50.00	5.00e-27	114.00
IUUC-Osa-086229	Oryza sativa	50.00	5.00e-27	114.00
IUUC-Ola-086315	Oryzias latipes	68.83	9.00e-115	406.00
IUUC-Oga-088067	Otolemur garnettii	93.81	1.00e-138	485.00
IUUC-Ptr-091404	Pan troglodytes	92.04	2.00e-107	380.00
IUUC-Pan-092424	Papio anubis	92.44	9.00e-147	512.00
IUUC-Psi-093171	Pelodiscus sinensis	83.96	2.00e-113	401.00
IUUC-Pma-094408	Petromyzon marinus	44.77	5.00e-63	234.00
IUUC-Ppa-095873	Physcomitrella patens	42.42	3.00e-25	109.00
IUUC-Pfo-097402	Poecilia formosa	72.26	4.00e-116	410.00
IUUC-Pab-097834	Pongo abelii	89.87	1.00e-103	368.00
IUUC-Pop-099462	Populus trichocarpa	50.51	3.00e-25	108.00
IUUC-Pca-100442	Procavia capensis	92.20	2.00e-100	358.00
IUUC-Ppe-101324	Prunus persica	49.54	1.00e-25	110.00
IUUC-Pva-103240	Pteropus vampyrus	93.31	6.00e-156	543.00
IUUC-Pgr-103273	Puccinia graminis	38.33	2.00e-17	83.20
IUUC-Ptt-103768	Puccinia triticina	38.83	2.00e-15	77.40
IUUC-Pte-104223	Pyrenophora teres	40.98	6.00e-21	95.90
IUUC-Pyt-104653	Pyrenophora triticirepentis	40.16	8.00e-21	95.10
IUUC-Rno-105203	Rattus norvegicus	92.10	2.00e-140	491.00
IUUC-Sha-107638	Sarcophilus harrisii	85.04	8.00e-127	446.00
IUUC-Ssl-108600	Sclerotinia sclerotiorum	34.00	1.00e-12	68.20
IUUC-Smo-109651	Selaginella moellendorffii	52.81	2.00e-23	100.00
IUUC-Sit-110648	Setaria italica	51.35	3.00e-28	118.00
IUUC-Sly-111407	Solanum lycopersicum	27.91	2.00e-26	112.00
IUUC-Stu-112467	Solanum tuberosum	31.43	7.00e-27	114.00
IUUC-Tgu-117502	Taeniopygia guttata	82.82	1.00e-119	422.00
IUUC-Tru-117681	Takifugu rubripes	71.58	6.00e-116	410.00
IUUC-Tni-120720	Tetraodon nigroviridis	70.21	2.00e-114	404.00
IUUC-Tca-121480	Theobroma cacao	48.08	1.00e-25	110.00
IUUC-Tae-124679	Triticum aestivum	46.73	1.00e-24	106.00
IUUC-Tur-125986	Triticum urartu	29.96	8.00e-23	102.00
IUUC-Ttr-128843	Tursiops truncatus	97.43	2.00e-151	528.00
IUUC-Vda-129671	Verticillium dahliae	32.86	4.00e-15	76.60
IUUC-Vvi-131691	Vitis vinifera	30.11	1.00e-25	110.00
IUUC-Xtr-132815	Xenopus tropicalis	57.44	1.00e-92	333.00
IUUC-Xma-133481	Xiphophorus maculatus	71.23	2.00e-115	408.00
IUUC-Zma-135326	Zea mays	50.00	2.00e-25	109.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence