iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-054522

UUCD1 version

UUC-LoA-00738

Ensembl Protein ID

ENSLAFP00000024301.1

UniProt Accession

G3U8Z3; G3U8Z3_LOXAF

Protein Name

Uncharacterized protein

Gene Name

TRIM59

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000020531.3	ENSLAFT00000020923.3	ENSLAFP00000024301.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	3.80e-06	27.2	6	89
E3 activity/RING/RING	9.20e-10	39.3	10	60

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggk...........tcPvtrqpl.....teedlvPnltlrrliqawcee 71
           +e+ CpI + +++dP vlp+ +t+ r+++e  l+ +g+           +cP +r+ +       e+l  n +l+++i+++ +e
   Q: 6    DELTCPICYSIFEDPRVLPCSHTFCRNCLENVLQASGNfyiwrplriplKCPSCRSIIeiastGIESLPVNFALKAIIEKYQQE 89
           7899*****************************999999***************998743321234555688999999998776 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefr..........CPlCr 46
           C+iC++ f+d p+vlpC H+f+++Cl+++     ++s++f+          CP Cr
   Q: 10   CPICYSIFED-PRVLPCSHTFCRNCLENV----LQASGNFYiwrplriplkCPSCR 60
           **********.***************999....667777766777777777****8 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MHNFEDELTC PICYSIFEDP RVLPCSHTFC RNCLENVLQA SGNFYIWRPL RIPLKCPSCR 60
SIIEIASTGI ESLPVNFALK AIIEKYQQED HPDIVTCPEH YRQPLNVYCL LDKKLVCGHC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCACAATT TTGAGGATGA GTTAACATGT CCCATTTGTT ACAGTATTTT TGAGGATCCT 60
CGTGTACTAC CATGCTCTCA TACATTTTGT AGAAATTGTT TGGAAAACGT TCTTCAGGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00643--zf-B_box
PF13445--zf-RING_UBOX

SMART

SM00184--RING

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0016021--C:integral component of membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0046597--P:negative regulation of viral entry into host cell

KEGG

lav:100664282

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002249	Ailuropoda melanoleuca	88.59	0.00e+00	737.00
IUUC-Apl-003996	Anas platyrhynchos	55.06	9.00e-121	426.00
IUUC-Aca-005141	Anolis carolinensis	55.69	2.00e-127	448.00
IUUC-Ame-011353	Astyanax mexicanus	50.49	2.00e-94	339.00
IUUC-Bta-013440	Bos taurus	89.20	0.00e+00	672.00
IUUC-Cfa-021168	Canis familiaris	88.28	0.00e+00	732.00
IUUC-Cpo-021702	Cavia porcellus	75.31	2.00e-176	611.00
IUUC-Csa-024141	Chlorocebus sabaeus	86.07	0.00e+00	655.00
IUUC-Dre-028408	Danio rerio	45.98	1.00e-85	309.00
IUUC-Dno-029180	Dasypus novemcinctus	87.31	0.00e+00	719.00
IUUC-Ete-033028	Echinops telfairi	87.42	1.00e-167	583.00
IUUC-Eca-034357	Equus caballus	87.06	0.00e+00	693.00
IUUC-Fca-036287	Felis catus	88.31	0.00e+00	731.00
IUUC-Gga-040739	Gallus gallus	57.39	3.00e-135	474.00
IUUC-Ggo-045307	Gorilla gorilla	84.58	0.00e+00	678.00
IUUC-Hsa-045690	Homo sapiens	85.07	0.00e+00	678.00
IUUC-Itr-048230	Ictidomys tridecemlineatus	89.55	0.00e+00	746.00
IUUC-Mcc-055145	Macaca mulatta	86.32	0.00e+00	690.00
IUUC-Meu-056214	Macropus eugenii	45.83	7.00e-56	210.00
IUUC-Mmr-061197	Microcebus murinus	90.80	0.00e+00	752.00
IUUC-Mdo-062631	Monodelphis domestica	59.65	7.00e-132	463.00
IUUC-Mmu-064217	Mus musculus	83.62	0.00e+00	679.00
IUUC-Mpu-065691	Mustela putorius furo	88.59	0.00e+00	740.00
IUUC-Mlu-067742	Myotis lucifugus	85.82	0.00e+00	691.00
IUUC-Nle-069722	Nomascus leucogenys	85.07	0.00e+00	710.00
IUUC-Oan-073382	Ornithorhynchus anatinus	58.21	3.00e-130	457.00
IUUC-Oar-089206	Ovis aries	87.28	0.00e+00	735.00
IUUC-Pan-092189	Papio anubis	86.32	0.00e+00	691.00
IUUC-Psi-093523	Pelodiscus sinensis	60.15	1.00e-139	489.00
IUUC-Pma-094162	Petromyzon marinus	37.13	2.00e-47	182.00
IUUC-Pfo-096032	Poecilia formosa	45.34	2.00e-84	306.00
IUUC-Pva-103089	Pteropus vampyrus	86.57	0.00e+00	702.00
IUUC-Pgr-103338	Puccinia graminis	38.71	1.00e-06	46.60
IUUC-Rno-105440	Rattus norvegicus	85.57	0.00e+00	692.00
IUUC-Ssc-115809	Sus scrofa	87.06	0.00e+00	690.00
IUUC-Tru-118402	Takifugu rubripes	42.66	2.00e-87	315.00
IUUC-Tni-119737	Tetraodon nigroviridis	44.37	2.00e-83	301.00
IUUC-Ttr-128921	Tursiops truncatus	88.53	0.00e+00	712.00
IUUC-Vpa-130397	Vicugna pacos	88.83	0.00e+00	736.00
IUUC-Xtr-132752	Xenopus tropicalis	48.56	2.00e-85	308.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence