iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	2.00e-16	60.0	375	422

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
           +++l+r+ p+SLqh+CR +I++c++++++   d+LP+P+ +k YL++++y+
   Q: 375  STPLIRTFPFSLQHICRTVICNCTTYDGI---DALPIPSPMKLYLKEYHYK 422
           678899***********************...****************985 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MAENNSKNVD VRPKTSRSRS ADRKDGYVWS GKKLSWSRKS ESCSESEAVG TLESVEIPLR 60
SQERELSCSS IELDLDHSCG HRFLGRSLKQ KLQDAVGQCF PIRNCGARHS PGLPSKRTIH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTGAGCGAG CGCCGGGTGA TGGCGATGGT GATGGCGGCA GTCCCTCGGA CAGCTCCGGT 60
TGAGCTGTGC TCAGAGAGGT GAGAGGGGGA AGGGTGGTGG TGAGGTCTGA GATTTTACGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028416--SOCS4
IPR022252--SOCS4/SOCS5_dom
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF12610--SOCS
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination

KEGG

rno:305828

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001789	Ailuropoda melanoleuca	86.04	0.00e+00	728.00
IUUC-Apl-003839	Anas platyrhynchos	73.80	9.00e-171	592.00
IUUC-Aca-004840	Anolis carolinensis	73.58	0.00e+00	642.00
IUUC-Ago-007739	Ashbya gossypii	29.57	2.60e+00	27.70
IUUC-Bta-012503	Bos taurus	84.74	0.00e+00	716.00
IUUC-Bol-016597	Brassica oleracea	32.81	1.60e-01	31.20
IUUC-Cja-019284	Callithrix jacchus	85.19	0.00e+00	723.00
IUUC-Cfa-020890	Canis familiaris	85.19	0.00e+00	724.00
IUUC-Cpo-022081	Cavia porcellus	76.24	0.00e+00	645.00
IUUC-Csa-023076	Chlorocebus sabaeus	85.02	0.00e+00	719.00
IUUC-Cho-024700	Choloepus hoffmanni	85.32	0.00e+00	757.00
IUUC-Dno-029961	Dasypus novemcinctus	86.47	0.00e+00	759.00
IUUC-Dor-030273	Dipodomys ordii	86.47	0.00e+00	727.00
IUUC-Ete-032972	Echinops telfairi	85.85	1.00e-163	568.00
IUUC-Eca-034289	Equus caballus	85.32	0.00e+00	722.00
IUUC-Eeu-035208	Erinaceus europaeus	83.91	0.00e+00	697.00
IUUC-Fal-036829	Ficedula albicollis	74.72	8.00e-170	589.00
IUUC-Gga-040725	Gallus gallus	73.12	3.00e-178	617.00
IUUC-Ggo-044886	Gorilla gorilla	85.19	0.00e+00	725.00
IUUC-Hsa-046322	Homo sapiens	84.97	0.00e+00	723.00
IUUC-Itr-048585	Ictidomys tridecemlineatus	86.44	0.00e+00	732.00
IUUC-Lch-049459	Latimeria chalumnae	54.48	9.00e-131	459.00
IUUC-Laf-053484	Loxodonta africana	86.67	0.00e+00	730.00
IUUC-Mcc-054890	Macaca mulatta	84.79	0.00e+00	717.00
IUUC-Meu-056532	Macropus eugenii	78.57	1.00e-174	605.00
IUUC-Mtr-057670	Medicago truncatula	39.29	2.20e+00	26.60
IUUC-Mvi-060418	Microbotryum violaceum	32.10	1.80e-02	32.70
IUUC-Mmr-061714	Microcebus murinus	86.44	0.00e+00	717.00
IUUC-Mmu-063161	Mus musculus	92.43	0.00e+00	780.00
IUUC-Mpu-066499	Mustela putorius furo	84.97	0.00e+00	747.00
IUUC-Mlu-066945	Myotis lucifugus	83.18	0.00e+00	702.00
IUUC-Nle-069976	Nomascus leucogenys	85.19	0.00e+00	723.00
IUUC-Opr-070255	Ochotona princeps	81.61	0.00e+00	701.00
IUUC-Ocu-074764	Oryctolagus cuniculus	85.78	0.00e+00	726.00
IUUC-Oga-088910	Otolemur garnettii	81.88	0.00e+00	709.00
IUUC-Oar-090330	Ovis aries	84.74	0.00e+00	716.00
IUUC-Ptr-090709	Pan troglodytes	85.19	0.00e+00	725.00
IUUC-Pan-092540	Papio anubis	85.02	0.00e+00	719.00
IUUC-Psi-093678	Pelodiscus sinensis	76.66	0.00e+00	689.00
IUUC-Pfo-097139	Poecilia formosa	80.35	1.00e-86	313.00
IUUC-Pab-097970	Pongo abelii	82.84	6.00e-171	593.00
IUUC-Pop-098820	Populus trichocarpa	41.18	1.60e-01	30.80
IUUC-Pca-100211	Procavia capensis	76.32	1.00e-175	608.00
IUUC-Sha-106822	Sarcophilus harrisii	79.08	0.00e+00	682.00
IUUC-Ssc-115821	Sus scrofa	85.55	0.00e+00	716.00
IUUC-Tgu-117117	Taeniopygia guttata	74.94	2.00e-170	592.00
IUUC-Tsy-118979	Tarsius syrichta	90.64	5.00e-120	423.00
IUUC-Tca-121131	Theobroma cacao	30.77	3.00e-03	35.80
IUUC-Vpa-130626	Vicugna pacos	84.74	0.00e+00	724.00
IUUC-Vvi-131327	Vitis vinifera	43.24	1.00e-01	31.20

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence