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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046035
Ensembl Protein ID ENSP00000320566.5
UniProt Accession Q9NXR8; A8K790; O60394; Q567P3; Q6GMT3; Q7Z762; Q969G0; Q96DT4; Q9HC99; Q9P081; ING3_HUMAN
Genbank Protein ID AAG12172.1; AAG23285.1; BAA90942.1; BAF84594.1; AAF28979.1; CAC48260.2; AAQ93373.1; AAH09777.1; AAQ93374.1; AAH10851.1; AAH09776.1; AAH62634.1; AAH73865.1; AAH93091.1; AAH93689.1; AAI01610.1
Protein Name Inhibitor of growth protein 3; p47ING3
Genbank Nucleotide ID AF074968; AY007790; AK000096; AK291905; AF161419; AL603623; AC004537; BC009777; BC009777; BC010851; BC062634; BC062634; BC073865; BC093091; BC093689; BC101609
Gene Name ING3; HSPC301
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000071243.15 ENST00000315870.9 ENSP00000320566.5
ENSG00000071243.15 ENST00000339121.9 ENSP00000341697.5
ENSG00000071243.15 ENST00000427726.5 ENSP00000410406.1
ENSG00000071243.15 ENST00000445699.5 ENSP00000395719.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
miRNAMapSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDABioGRID
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 4.40e-09 38.0 361 408
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggedekslveCek..Cr.ewfHpaClklsveeelpnsekwiCpkCrs 53
           ++C +C + + +e  +v C++  C  ewfH++C++l+   e p+ + w+Cp+C++
   Q: 361  RYC-ICNQVSYGE--MVGCDNqdCPiEWFHYGCVGLT---EAPKGK-WYCPQCTA 408
           69*.*******99..*****999*99***********...999997.******86 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.
 Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.
Protein Sequence
(Fasta)
MLYLEDYLEM IEQLPMDLRD RFTEMREMDL QVQNAMDQLE QRVSEFFMNA KKNKPEWREE 60
QMASIKKDYY KALEDADEKV QLANQIYDLV DRHLRKLDQE LAKFKMELEA DNAGITEILE 120
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Protein Fasta Sequence


>IUUC-Hsa-046035|E3,PHD|Homo sapiens
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Nucleotide Sequence
(Fasta)
TTTTTTTTTT TTTCTTTTTT TTTTTTTGCC GGAGTCGAGC GGGTGCTGCT AGCGGAGGCG 60
CCATATTGGA GGGGACAAAA CTCCGGCGAC AGCGAGTGAC ACAAATAAAC CCCTGGACCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046035|E3,PHD|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-0341--Growth regulation
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF12998--ING
SMART

SM01408--ING
SM00249--PHD
Gene Ontology

GO:0035267--C:NuA4 histone acetyltransferase complex
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0032777--C:Piccolo NuA4 histone acetyltransferase complex
GO:0000812--C:Swr1 complex
GO:0035064--F:methylated histone binding
GO:0008270--F:zinc ion binding
GO:0043968--P:histone H2A acetylation
GO:0043967--P:histone H4 acetylation
GO:0043065--P:positive regulation of apoptotic process
GO:0040008--P:regulation of growth
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG hsa:54556
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002275 Ailuropoda melanoleuca 99.04 0.00e+00 685.00
IUUC-Apl-003660 Anas platyrhynchos 87.81 5.00e-157 547.00
IUUC-Aca-005206 Anolis carolinensis 89.47 1.00e-164 572.00
IUUC-Aly-005815 Arabidopsis lyrata 68.12 1.00e-28 120.00
IUUC-Ath-006765 Arabidopsis thaliana 66.67 5.00e-28 117.00
IUUC-Acl-008091 Aspergillus clavatus 62.26 7.00e-19 89.40
IUUC-Ate-010297 Aspergillus terreus 62.26 4.00e-19 90.10
IUUC-Ame-011952 Astyanax mexicanus 82.62 2.00e-158 551.00
IUUC-Bta-012562 Bos taurus 98.09 0.00e+00 684.00
IUUC-Cja-019646 Callithrix jacchus 98.09 0.00e+00 680.00
IUUC-Cfa-020874 Canis familiaris 99.04 0.00e+00 686.00
IUUC-Cpo-022530 Cavia porcellus 98.33 0.00e+00 669.00
IUUC-Csa-024232 Chlorocebus sabaeus 99.52 0.00e+00 691.00
IUUC-Cho-025039 Choloepus hoffmanni 96.65 0.00e+00 660.00
IUUC-Cin-025233 Ciona intestinalis 59.14 3.00e-52 199.00
IUUC-Csv-025900 Ciona savignyi 61.82 6.00e-52 198.00
IUUC-Dre-027397 Danio rerio 78.81 2.00e-148 519.00
IUUC-Dno-029289 Dasypus novemcinctus 98.80 0.00e+00 684.00
IUUC-Dse-031323 Dothistroma septosporum 55.93 4.00e-18 86.70
IUUC-Ete-032510 Echinops telfairi 89.23 3.00e-155 541.00
IUUC-Eca-033770 Equus caballus 99.28 0.00e+00 686.00
IUUC-Fca-035661 Felis catus 98.09 0.00e+00 680.00
IUUC-Fal-037051 Ficedula albicollis 90.39 2.00e-153 535.00
IUUC-Gmo-039123 Gadus morhua 79.52 5.00e-160 557.00
IUUC-Gga-040794 Gallus gallus 91.87 1.00e-172 599.00
IUUC-Gac-042167 Gasterosteus aculeatus 79.33 4.00e-156 544.00
IUUC-Ggo-044586 Gorilla gorilla 85.78 2.00e-170 592.00
IUUC-Itr-048783 Ictidomys tridecemlineatus 99.28 0.00e+00 686.00
IUUC-Lch-049419 Latimeria chalumnae 83.97 2.00e-174 605.00
IUUC-Loc-052246 Lepisosteus oculatus 85.48 1.00e-166 578.00
IUUC-Lma-053234 Leptosphaeria maculans 53.85 3.00e-17 84.30
IUUC-Laf-053617 Loxodonta africana 98.09 0.00e+00 659.00
IUUC-Mcc-055192 Macaca mulatta 96.65 0.00e+00 655.00
IUUC-Meu-056848 Macropus eugenii 81.10 3.00e-144 504.00
IUUC-Mga-059899 Meleagris gallopavo 90.91 2.00e-151 528.00
IUUC-Mmr-061435 Microcebus murinus 95.94 0.00e+00 646.00
IUUC-Mmu-064032 Mus musculus 94.54 0.00e+00 666.00
IUUC-Mpu-066530 Mustela putorius furo 98.56 0.00e+00 687.00
IUUC-Mlu-067790 Myotis lucifugus 99.04 0.00e+00 685.00
IUUC-Nle-070171 Nomascus leucogenys 100.00 0.00e+00 692.00
IUUC-Opr-070865 Ochotona princeps 75.59 4.00e-76 278.00
IUUC-Ont-072045 Oreochromis niloticus 81.75 1.00e-159 556.00
IUUC-Oan-073641 Ornithorhynchus anatinus 89.82 2.00e-158 551.00
IUUC-Ocu-074613 Oryctolagus cuniculus 98.80 0.00e+00 685.00
IUUC-Oga-088624 Otolemur garnettii 98.57 0.00e+00 672.00
IUUC-Oar-089442 Ovis aries 97.61 0.00e+00 678.00
IUUC-Ptr-091208 Pan troglodytes 100.00 0.00e+00 692.00
IUUC-Pan-092715 Papio anubis 99.76 0.00e+00 691.00
IUUC-Psi-093455 Pelodiscus sinensis 90.91 2.00e-171 595.00
IUUC-Pma-094144 Petromyzon marinus 79.78 2.00e-44 171.00
IUUC-Pfo-096573 Poecilia formosa 82.86 6.00e-159 553.00
IUUC-Pab-097549 Pongo abelii 100.00 0.00e+00 692.00
IUUC-Pca-100198 Procavia capensis 94.02 0.00e+00 659.00
IUUC-Pva-102440 Pteropus vampyrus 97.85 0.00e+00 678.00
IUUC-Pte-104284 Pyrenophora teres 54.24 3.00e-17 84.30
IUUC-Pyt-104787 Pyrenophora triticirepentis 55.93 2.00e-17 84.70
IUUC-Rno-105532 Rattus norvegicus 95.72 0.00e+00 657.00
IUUC-Sha-107475 Sarcophilus harrisii 94.02 0.00e+00 631.00
IUUC-Sar-113193 Sorex araneus 96.89 0.00e+00 665.00
IUUC-Ssc-115795 Sus scrofa 98.33 0.00e+00 682.00
IUUC-Tgu-117305 Taeniopygia guttata 90.39 2.00e-155 542.00
IUUC-Tru-117691 Takifugu rubripes 79.33 3.00e-150 525.00
IUUC-Tsy-119035 Tarsius syrichta 87.16 3.00e-95 341.00
IUUC-Tni-120738 Tetraodon nigroviridis 77.14 1.00e-156 545.00
IUUC-Tre-121950 Trichoderma reesei 61.11 3.00e-19 90.90
IUUC-Ttr-128512 Tursiops truncatus 93.54 0.00e+00 681.00
IUUC-Xma-133522 Xiphophorus maculatus 83.10 1.00e-159 555.00
IUUC-Zma-135298 Zea mays 67.80 2.00e-24 106.00
Created Date 25-Jun-2017

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