iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	7.00e-45	151.2	197	256

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +++vq+ly++++++++eL+++kG++++viek e+d +W+k+ k+++g+ Gl+P+n+v+ l+
   Q: 197  LHVVQTLYPFSSVTEEELSFEKGETMEVIEKPENDPEWWKC-KNARGQVGLVPKNYVVVLS 256
           689**************************************.7**************9886 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MTEEVIVIAK WDYTAQQDQE LDIRKNERLW LLDDSKTWWR VRNAANRTGY VPSNYVERKN 60
SLKKGSLVKN LKDTLGLGKT RRKPSARDAS PTPSTDAEYP ANGSGADRIY DLNIPAFVKF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAGCGGCAT CTGGGCGGGC GCAGCGCGGC CGCCGCCCCG GGACTAGCGC TGCTGCCCTC 60
CGGCCTCGGC GTGCACTGTG CAGCGAGGTA AGGCGATGGC GGGGGCTGCA AACTTGGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0418--Kinase
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase

Interpro

IPR017304--NCK
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF14604--SH3_9

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0014069--C:postsynaptic density
GO:0045202--C:synapse
GO:0012506--C:vesicle membrane
GO:0016301--F:kinase activity
GO:0007015--P:actin filament organization
GO:0016477--P:cell migration
GO:0060996--P:dendritic spine development
GO:0048013--P:ephrin receptor signaling pathway
GO:0001771--P:immunological synapse formation
GO:0030032--P:lamellipodium assembly
GO:1903912--P:negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0033137--P:negative regulation of peptidyl-serine phosphorylation
GO:1903898--P:negative regulation of PERK-mediated unfolded protein response
GO:1990441--P:negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0030838--P:positive regulation of actin filament polymerization
GO:1902237--P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0036493--P:positive regulation of translation in response to endoplasmic reticulum stress

KEGG

rno:316369

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001404	Ailuropoda melanoleuca	94.74	0.00e+00	719.00
IUUC-Apl-003456	Anas platyrhynchos	89.47	0.00e+00	695.00
IUUC-Aca-005105	Anolis carolinensis	88.68	0.00e+00	691.00
IUUC-Ame-010966	Astyanax mexicanus	78.33	5.00e-174	603.00
IUUC-Bta-012424	Bos taurus	87.37	5.00e-180	623.00
IUUC-Cel-018144	Caenorhabditis elegans	42.01	5.00e-75	274.00
IUUC-Cja-019898	Callithrix jacchus	95.53	0.00e+00	723.00
IUUC-Cfa-020830	Canis familiaris	94.47	0.00e+00	715.00
IUUC-Cpo-021487	Cavia porcellus	88.42	0.00e+00	646.00
IUUC-Csa-023693	Chlorocebus sabaeus	95.53	0.00e+00	723.00
IUUC-Cin-025348	Ciona intestinalis	37.76	8.00e-68	250.00
IUUC-Csv-026046	Ciona savignyi	39.15	1.00e-69	256.00
IUUC-Dre-028334	Danio rerio	80.68	3.00e-175	607.00
IUUC-Dno-028973	Dasypus novemcinctus	92.63	0.00e+00	707.00
IUUC-Dor-031003	Dipodomys ordii	96.05	0.00e+00	705.00
IUUC-Dme-031846	Drosophila melanogaster	43.77	1.00e-88	320.00
IUUC-Ete-032792	Echinops telfairi	84.11	0.00e+00	635.00
IUUC-Eca-033656	Equus caballus	95.00	0.00e+00	719.00
IUUC-Fca-036347	Felis catus	94.74	0.00e+00	719.00
IUUC-Fal-037095	Ficedula albicollis	89.21	0.00e+00	696.00
IUUC-Gmo-039410	Gadus morhua	70.66	4.00e-158	550.00
IUUC-Gga-040155	Gallus gallus	89.47	0.00e+00	695.00
IUUC-Gac-041787	Gasterosteus aculeatus	72.59	7.00e-164	570.00
IUUC-Ggo-044805	Gorilla gorilla	95.79	0.00e+00	724.00
IUUC-Hsa-046585	Homo sapiens	95.79	0.00e+00	724.00
IUUC-Itr-048887	Ictidomys tridecemlineatus	95.53	0.00e+00	717.00
IUUC-Lch-049795	Latimeria chalumnae	86.05	0.00e+00	667.00
IUUC-Loc-051985	Lepisosteus oculatus	86.05	0.00e+00	644.00
IUUC-Laf-054228	Loxodonta africana	92.89	0.00e+00	710.00
IUUC-Mcc-055402	Macaca mulatta	95.53	0.00e+00	723.00
IUUC-Mga-059374	Meleagris gallopavo	89.47	0.00e+00	695.00
IUUC-Mmr-061453	Microcebus murinus	95.53	0.00e+00	724.00
IUUC-Mdo-063080	Monodelphis domestica	88.68	0.00e+00	691.00
IUUC-Mmu-063529	Mus musculus	99.74	0.00e+00	739.00
IUUC-Mpu-066815	Mustela putorius furo	94.74	0.00e+00	719.00
IUUC-Mlu-067132	Myotis lucifugus	92.79	7.00e-157	546.00
IUUC-Nle-069371	Nomascus leucogenys	95.79	0.00e+00	724.00
IUUC-Opr-070948	Ochotona princeps	94.69	0.00e+00	695.00
IUUC-Ont-071410	Oreochromis niloticus	74.44	1.00e-159	555.00
IUUC-Oan-073304	Ornithorhynchus anatinus	87.58	1.00e-155	541.00
IUUC-Ocu-074783	Oryctolagus cuniculus	95.26	0.00e+00	716.00
IUUC-Ola-086808	Oryzias latipes	72.84	9.00e-158	549.00
IUUC-Oga-088391	Otolemur garnettii	96.05	0.00e+00	720.00
IUUC-Oar-090025	Ovis aries	80.79	4.00e-166	577.00
IUUC-Ptr-090975	Pan troglodytes	95.79	0.00e+00	724.00
IUUC-Pan-092287	Papio anubis	95.53	0.00e+00	723.00
IUUC-Psi-093413	Pelodiscus sinensis	89.74	0.00e+00	697.00
IUUC-Pfo-097129	Poecilia formosa	75.95	5.00e-165	573.00
IUUC-Pab-098756	Pongo abelii	95.79	0.00e+00	724.00
IUUC-Pca-100235	Procavia capensis	79.21	6.00e-178	616.00
IUUC-Pva-102294	Pteropus vampyrus	91.58	0.00e+00	684.00
IUUC-Sha-107521	Sarcophilus harrisii	89.21	0.00e+00	694.00
IUUC-Sar-113697	Sorex araneus	88.54	0.00e+00	660.00
IUUC-Ssc-115958	Sus scrofa	87.03	1.00e-159	555.00
IUUC-Tgu-116559	Taeniopygia guttata	87.37	0.00e+00	670.00
IUUC-Tru-117677	Takifugu rubripes	75.95	3.00e-163	568.00
IUUC-Tni-120434	Tetraodon nigroviridis	76.23	1.00e-163	568.00
IUUC-Tbe-127931	Tupaia belangeri	93.67	4.00e-174	603.00
IUUC-Ttr-128993	Tursiops truncatus	87.37	0.00e+00	642.00
IUUC-Xtr-132543	Xenopus tropicalis	82.94	0.00e+00	654.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence