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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-045787
UUCD1 version UUC-HoS-00871
Ensembl Protein ID ENSP00000430955.1
UniProt Accession Q96MT1; B7Z903; B7Z949; E7EVI7; Q8IVP7; RN145_HUMAN
Genbank Protein ID BAB71200.1; BAH14139.1; BAH14185.1; AAH42684.1
Protein Name RING finger protein 145
Genbank Nucleotide ID AK056513; AK304228; AK304435; AK308394
Gene Name RNF145
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000145860.11 ENST00000274542.6 ENSP00000274542.2
ENSG00000145860.11 ENST00000521606.6 ENSP00000430753.2
ENSG00000145860.11 ENST00000518802.5 ENSP00000430955.1
ENSG00000145860.11 ENST00000520638.1 ENSP00000429071.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 3.00e-09 38.9 567 604
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           CaiC++d+k   +++pC H+fha Cl+kw       + + +CPlC
   Q: 567  CAICYQDMKS-AVITPCSHFFHAGCLKKW------LYVQETCPLC 604
           ********99.888***************......********** PP
   
Organism Homo sapiens
Protein Sequence
(Fasta)
MHRDRISPSN SPTWSLQVFS KKKKKKKKNN MAAKEKLEAV LNVALRVPSI MLLDVLYRWD 60
VSSFFQQIQR SSLSNNPLFQ YKYLALNMHY VGYILSVVLL TLPRQHLVQL YLYFLTALLL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045787|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATTCATTCAT CCAGTCACTT ACTCCACAGG GGTTTGAGTG CCTGCACTTG GTGCTGGGCA 60
CGGCTGAGCC ATCCCAGACG CCAAGGAGTT TACAGTCTAG TCCAGTCAGT GACGAGGTTA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045787|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR025754--TRC8_N_dom
IPR001841--Znf_RING
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13705--TRC8_N
PF13639--zf-RING_2
SMART

SM00184--RING
SM00744--RINGv
Gene Ontology

GO:0016021--C:integral component of membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG hsa:153830
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002354 Ailuropoda melanoleuca 95.26 0.00e+00 1213.00
IUUC-Apl-003823 Anas platyrhynchos 90.05 0.00e+00 1124.00
IUUC-Aca-004944 Anolis carolinensis 94.69 0.00e+00 1109.00
IUUC-Ame-011578 Astyanax mexicanus 88.79 0.00e+00 1007.00
IUUC-Bta-012560 Bos taurus 90.27 0.00e+00 1170.00
IUUC-Cel-018539 Caenorhabditis elegans 28.41 9.00e-63 235.00
IUUC-Cja-018929 Callithrix jacchus 97.04 0.00e+00 1244.00
IUUC-Cfa-021110 Canis familiaris 96.68 0.00e+00 1222.00
IUUC-Cpo-022452 Cavia porcellus 94.42 0.00e+00 1182.00
IUUC-Csa-024116 Chlorocebus sabaeus 99.40 0.00e+00 1267.00
IUUC-Csv-025845 Ciona savignyi 40.62 1.00e-32 132.00
IUUC-Dre-028299 Danio rerio 88.62 0.00e+00 1040.00
IUUC-Dno-029615 Dasypus novemcinctus 95.76 0.00e+00 1204.00
IUUC-Ete-032551 Echinops telfairi 70.72 0.00e+00 861.00
IUUC-Eca-033349 Equus caballus 97.27 0.00e+00 1120.00
IUUC-Eeu-035349 Erinaceus europaeus 98.05 0.00e+00 716.00
IUUC-Fca-035696 Felis catus 96.67 0.00e+00 1213.00
IUUC-Fal-037495 Ficedula albicollis 88.30 0.00e+00 1099.00
IUUC-Gmo-039374 Gadus morhua 85.08 0.00e+00 998.00
IUUC-Gga-040146 Gallus gallus 90.59 0.00e+00 1113.00
IUUC-Gac-041731 Gasterosteus aculeatus 83.44 0.00e+00 1015.00
IUUC-Ggo-045158 Gorilla gorilla 99.70 0.00e+00 1257.00
IUUC-Itr-048928 Ictidomys tridecemlineatus 95.38 0.00e+00 1094.00
IUUC-Lch-050499 Latimeria chalumnae 90.06 0.00e+00 1051.00
IUUC-Loc-052482 Lepisosteus oculatus 92.81 0.00e+00 1039.00
IUUC-Laf-053362 Loxodonta africana 96.35 0.00e+00 1200.00
IUUC-Mcc-055779 Macaca mulatta 98.84 0.00e+00 1282.00
IUUC-Meu-056130 Macropus eugenii 73.37 7.00e-150 524.00
IUUC-Mga-059742 Meleagris gallopavo 93.33 0.00e+00 1112.00
IUUC-Mmr-060812 Microcebus murinus 98.20 0.00e+00 1254.00
IUUC-Mdo-063045 Monodelphis domestica 92.69 0.00e+00 1127.00
IUUC-Mmu-064377 Mus musculus 93.82 0.00e+00 1191.00
IUUC-Mpu-066637 Mustela putorius furo 96.68 0.00e+00 1216.00
IUUC-Mlu-066985 Myotis lucifugus 94.92 0.00e+00 1173.00
IUUC-Nle-069833 Nomascus leucogenys 99.54 0.00e+00 1255.00
IUUC-Opr-070210 Ochotona princeps 85.07 2.00e-138 486.00
IUUC-Ont-072116 Oreochromis niloticus 83.10 0.00e+00 1039.00
IUUC-Oan-073730 Ornithorhynchus anatinus 93.36 0.00e+00 1139.00
IUUC-Ocu-074958 Oryctolagus cuniculus 95.02 0.00e+00 1201.00
IUUC-Ola-087368 Oryzias latipes 88.97 0.00e+00 1019.00
IUUC-Oga-088301 Otolemur garnettii 98.01 0.00e+00 1229.00
IUUC-Oar-089745 Ovis aries 95.02 0.00e+00 1191.00
IUUC-Ptr-091397 Pan troglodytes 99.86 0.00e+00 1317.00
IUUC-Pan-092817 Papio anubis 99.55 0.00e+00 1268.00
IUUC-Psi-093820 Pelodiscus sinensis 87.52 0.00e+00 1078.00
IUUC-Pma-094457 Petromyzon marinus 66.87 3.00e-171 594.00
IUUC-Pfo-097173 Poecilia formosa 83.25 0.00e+00 1029.00
IUUC-Pab-097630 Pongo abelii 99.55 0.00e+00 1265.00
IUUC-Pca-100472 Procavia capensis 92.62 0.00e+00 1164.00
IUUC-Pva-102485 Pteropus vampyrus 94.44 0.00e+00 1118.00
IUUC-Rno-106029 Rattus norvegicus 94.43 0.00e+00 1159.00
IUUC-Sha-106580 Sarcophilus harrisii 92.97 0.00e+00 1149.00
IUUC-Ssc-116438 Sus scrofa 94.44 0.00e+00 1088.00
IUUC-Tgu-116638 Taeniopygia guttata 89.59 0.00e+00 1095.00
IUUC-Tru-117779 Takifugu rubripes 85.78 0.00e+00 1031.00
IUUC-Tsy-119541 Tarsius syrichta 94.63 0.00e+00 1164.00
IUUC-Tni-119862 Tetraodon nigroviridis 85.65 0.00e+00 1031.00
IUUC-Tbe-127328 Tupaia belangeri 89.91 0.00e+00 1060.00
IUUC-Ttr-129066 Tursiops truncatus 95.33 2.00e-179 622.00
IUUC-Xtr-132826 Xenopus tropicalis 86.94 0.00e+00 1084.00
Created Date 25-Jun-2017

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