iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-071901

Ensembl Protein ID

ENSONIP00000023089.1

UniProt Accession

I3KPP4; I3KPP4_ORENI

Genbank Protein ID

ENSONIP00000023089

Protein Name

Ubiquitin thioesterase

Genbank Nucleotide ID

AERX01024193

Gene Name

otub1b; otub1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000018335.1	ENSONIT00000023109.1	ENSONIP00000023089.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	1.60e-45	155.3	89	279

Active Site

Position(s)	Description	Evidence
96	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
99	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
273		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs..........................................................llgvfdddslsd 32
           +i+kt++DGnC++rA++++                                                          +l +f+d+ +sd
   Q: 89   YIRKTRPDGNCFYRAFGFAhlesllddskelqkfkavaakskldlvnegfteftiedfhntfmdlielcekqprlqeVLSSFNDQNVSD 177
           89*************************************************************************************** PP
   S: 33   alveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklk 120
           ++v++Lr+lts ylq+e+ ff++fie+++++kefcq++vep++k +++ihi+aLaq+L ++i v+++d++e   gg++++++fpe   +
   Q: 178  YVVVYLRLLTSGYLQREHTFFQHFIEGGRTVKEFCQQEVEPMSKeSDHIHIIALAQALDVSILVEYMDRGE---GGTVNHHVFPEGG-D 262
           **********************************************************************9...9************.* PP
   S: 121  kpivLlYrsgHYdaLva 137
           ++i LlYr+gHYd+L++
   Q: 263  PRIFLLYRPGHYDILYK 279
           ***************96 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MSCGGRKPIS TAKMAEEQQE SSQGEMEGVN CLAYDEAIIA QQDRIQQEIA TSNPLVSDRQ 60
DLSVLQSEYA EDDTVYQLKI KDLHKKYSYI RKTRPDGNCF YRAFGFAHLE SLLDDSKELQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTATGATATA ATAAAGAAAT AAATGTATAT TAAATATGAC ATAATACTGT AATTATGTAA 60
ATAAATGCAT TATTTTCTGG TAAAACATCA GCCAATGGAA TGTACTGGAA GCCTCGTATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003323--OTU_dom
IPR030298--OTUB1
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0071108--P:protein K48-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001871	Ailuropoda melanoleuca	79.34	1.00e-127	449.00
IUUC-Apl-003233	Anas platyrhynchos	52.31	2.00e-15	73.60
IUUC-Aca-004648	Anolis carolinensis	77.82	8.00e-118	416.00
IUUC-Aly-005710	Arabidopsis lyrata	41.88	5.00e-52	197.00
IUUC-Ath-007112	Arabidopsis thaliana	41.73	4.00e-51	194.00
IUUC-Afl-008439	Aspergillus flavus	32.91	6.00e-07	47.80
IUUC-Ame-010662	Astyanax mexicanus	91.35	7.00e-147	512.00
IUUC-Bta-013533	Bos taurus	82.61	8.00e-126	442.00
IUUC-Bol-016100	Brassica oleracea	42.21	1.00e-50	193.00
IUUC-Bra-017705	Brassica rapa	38.33	4.00e-44	171.00
IUUC-Cel-018295	Caenorhabditis elegans	34.80	9.00e-41	160.00
IUUC-Cja-019190	Callithrix jacchus	82.61	3.00e-126	444.00
IUUC-Cfa-020430	Canis familiaris	81.89	2.00e-125	441.00
IUUC-Cpo-022355	Cavia porcellus	83.00	1.00e-126	445.00
IUUC-Cre-022997	Chlamydomonas reinhardtii	38.15	5.00e-44	171.00
IUUC-Csa-023286	Chlorocebus sabaeus	79.77	8.00e-124	436.00
IUUC-Cho-024411	Choloepus hoffmanni	42.54	1.00e-27	116.00
IUUC-Cin-025507	Ciona intestinalis	45.56	4.00e-45	174.00
IUUC-Csv-026273	Ciona savignyi	47.17	2.00e-67	248.00
IUUC-Dre-028315	Danio rerio	89.51	2.00e-134	471.00
IUUC-Dno-029165	Dasypus novemcinctus	82.50	4.00e-100	357.00
IUUC-Dor-030943	Dipodomys ordii	83.00	1.00e-126	445.00
IUUC-Dme-031922	Drosophila melanogaster	54.80	2.00e-74	271.00
IUUC-Ete-032296	Echinops telfairi	78.62	2.00e-73	269.00
IUUC-Eca-033695	Equus caballus	81.50	3.00e-125	441.00
IUUC-Eeu-034775	Erinaceus europaeus	44.74	2.00e-56	211.00
IUUC-Fca-036441	Felis catus	81.89	2.00e-125	441.00
IUUC-Gmo-038908	Gadus morhua	92.22	3.00e-149	520.00
IUUC-Ggr-040020	Gaeumannomyces graminis	33.21	5.00e-32	132.00
IUUC-Gga-040460	Gallus gallus	71.00	3.00e-114	404.00
IUUC-Gac-042417	Gasterosteus aculeatus	93.73	1.00e-143	502.00
IUUC-Gma-043712	Glycine max	41.64	2.00e-50	192.00
IUUC-Ggo-044552	Gorilla gorilla	80.50	1.00e-75	276.00
IUUC-Hsa-046766	Homo sapiens	82.61	2.00e-126	445.00
IUUC-Itr-048312	Ictidomys tridecemlineatus	83.00	1.00e-126	445.00
IUUC-Lch-050602	Latimeria chalumnae	75.40	1.00e-112	399.00
IUUC-Laf-053705	Loxodonta africana	83.00	1.00e-126	445.00
IUUC-Mcc-055745	Macaca mulatta	77.12	6.00e-123	433.00
IUUC-Meu-056569	Macropus eugenii	73.52	2.00e-109	388.00
IUUC-Mtr-057712	Medicago truncatula	40.28	1.00e-46	179.00
IUUC-Mvi-060358	Microbotryum violaceum	33.33	1.00e-16	80.10
IUUC-Mmr-061123	Microcebus murinus	83.57	1.00e-104	372.00
IUUC-Mdo-062613	Monodelphis domestica	73.53	1.00e-102	365.00
IUUC-Mmu-063658	Mus musculus	83.00	1.00e-126	445.00
IUUC-Mac-065274	Musa acuminata	34.80	2.00e-35	143.00
IUUC-Mpu-066172	Mustela putorius furo	82.61	2.00e-126	445.00
IUUC-Mlu-066966	Myotis lucifugus	81.96	2.00e-126	445.00
IUUC-Nle-069519	Nomascus leucogenys	71.12	2.00e-76	279.00
IUUC-Oan-072922	Ornithorhynchus anatinus	44.64	3.00e-57	214.00
IUUC-Ocu-074643	Oryctolagus cuniculus	44.74	1.00e-56	213.00
IUUC-Oni-082026	Oryza nivara	27.78	1.00e-12	68.20
IUUC-Oru-084761	Oryza rufipogon	27.78	1.00e-12	68.20
IUUC-Ola-087331	Oryzias latipes	93.82	7.00e-99	353.00
IUUC-Oga-088064	Otolemur garnettii	82.61	2.00e-126	445.00
IUUC-Oar-089251	Ovis aries	82.21	3.00e-124	437.00
IUUC-Ptr-091430	Pan troglodytes	82.61	3.00e-126	444.00
IUUC-Pan-091969	Papio anubis	45.18	3.00e-57	214.00
IUUC-Psi-093823	Pelodiscus sinensis	75.95	8.00e-117	412.00
IUUC-Pma-094366	Petromyzon marinus	70.63	4.00e-101	360.00
IUUC-Pfo-096734	Poecilia formosa	92.43	2.00e-131	461.00
IUUC-Pab-097919	Pongo abelii	83.57	1.00e-103	369.00
IUUC-Pop-099401	Populus trichocarpa	39.52	3.00e-48	185.00
IUUC-Ppe-101977	Prunus persica	41.26	3.00e-50	192.00
IUUC-Pva-102499	Pteropus vampyrus	82.47	7.00e-125	439.00
IUUC-Rno-105233	Rattus norvegicus	83.00	1.00e-126	445.00
IUUC-Sha-107081	Sarcophilus harrisii	81.75	1.00e-124	439.00
IUUC-Sly-111640	Solanum lycopersicum	40.52	2.00e-47	182.00
IUUC-Sar-113295	Sorex araneus	45.61	5.00e-56	210.00
IUUC-Ssc-116202	Sus scrofa	82.61	2.00e-126	445.00
IUUC-Tru-117664	Takifugu rubripes	91.18	5.00e-147	513.00
IUUC-Tca-121467	Theobroma cacao	40.07	8.00e-49	187.00
IUUC-Tbe-128116	Tupaia belangeri	79.50	2.00e-76	278.00
IUUC-Ttr-128622	Tursiops truncatus	81.82	8.00e-124	436.00
IUUC-Uma-129443	Ustilago maydis	31.40	6.00e-25	108.00
IUUC-Vvi-131389	Vitis vinifera	41.18	7.00e-50	191.00
IUUC-Xtr-131951	Xenopus tropicalis	44.30	6.00e-55	207.00
IUUC-Xma-134191	Xiphophorus maculatus	92.83	6.00e-132	463.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence