iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046112

Ensembl Protein ID

ENSP00000269886.2

UniProt Accession

Q99961; B4DRA1; E7EVZ4; M0QZV5; Q99668; SH3G1_HUMAN

Genbank Protein ID

CAA67970.1; AAB86800.1; AAF04290.1; BAG61213.1; AAH01270.1

Protein Name

Endophilin-A2; EEN fusion partner of MLL; Endophilin-2; Extra eleven-nineteen leukemia fusion gene protein; SH3 domain protein 2B; SH3 domain-containing GRB2-like protein 1

Genbank Nucleotide ID

X99656; U65999; AF190465; AK299166; AK097616

Gene Name

SH3GL1; CNSA1; SH3D2B

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000141985.9	ENST00000269886.7	ENSP00000269886.2
ENSG00000141985.9	ENST00000598564.5	ENSP00000470792.1
ENSG00000141985.9	ENST00000417295.6	ENSP00000404568.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	miRWalk	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.20e-13	52.5	310	363

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
            +++lyd+e++nd+eL +++Gdv+++   ++ de+W +g   l g++G+fP  +ve l
   Q: 310  SCKALYDFEPENDGELGFHEGDVITLT--NQIDENWYEG--MLDGQSGFFPLSYVEVL 363
           69************************7..99********..8*************976 PP

Organism

Homo sapiens

Functional Description
(View)

Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity).

Protein Sequence
(Fasta)

MSVAGLKKQF YKASQLVSEK VGGAEGTKLD DDFKEMEKKV DVTSKAVTEV LARTIEYLQP 60
NPASRAKLTM LNTVSKIRGQ VKNPGYPQSE GLLGECMIRH GKELGGESNF GDALLDAGES 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATATCCTGG CCGCGCGGGC GCGCGAGCGG CTGAGGCGGC GCCGGGGCGG GCGCGGAGCT 60
GGCAAGCGGG TGGCGGAGGC GGCGCCGACG GGGACTGCTG AGGCGCGCAG AGGGTCGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0965--Cell junction
KW-0966--Cell projection
KW-0160--Chromosomal rearrangement
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0254--Endocytosis
KW-0967--Endosome
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR027267--AH/BAR-dom
IPR004148--BAR_dom
IPR001452--SH3_domain

PROSITE

PS51021--BAR
PS50002--SH3

Pfam

PF03114--BAR
PF00018--SH3_1

PRINTS

PR00452--SH3DOMAIN

SMART

SM00721--BAR
SM00326--SH3

Gene Ontology

GO:0030054--C:cell junction
GO:0042995--C:cell projection
GO:0005737--C:cytoplasm
GO:0031901--C:early endosome membrane
GO:0002102--C:podosome
GO:0045202--C:synapse
GO:0045296--F:cadherin binding
GO:0042802--F:identical protein binding
GO:0008289--F:lipid binding
GO:0007417--P:central nervous system development
GO:0007165--P:signal transduction
GO:0016191--P:synaptic vesicle uncoating

KEGG

hsa:6455

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001620	Ailuropoda melanoleuca	96.11	0.00e+00	672.00
IUUC-Apl-004209	Anas platyrhynchos	90.17	2.00e-175	607.00
IUUC-Ame-011047	Astyanax mexicanus	74.80	9.00e-155	539.00
IUUC-Bgr-012305	Blumeria graminis	40.68	3.00e-11	64.30
IUUC-Bta-012875	Bos taurus	97.01	0.00e+00	737.00
IUUC-Cel-018509	Caenorhabditis elegans	44.76	2.00e-93	335.00
IUUC-Cin-025799	Ciona intestinalis	50.41	2.00e-103	369.00
IUUC-Csv-026266	Ciona savignyi	52.21	1.00e-102	366.00
IUUC-Cne-027089	Cryptococcus neoformans	26.23	3.00e-08	53.50
IUUC-Dre-027986	Danio rerio	75.07	3.00e-157	548.00
IUUC-Dno-029193	Dasypus novemcinctus	95.92	0.00e+00	694.00
IUUC-Dor-030288	Dipodomys ordii	85.60	5.00e-174	603.00
IUUC-Eca-033277	Equus caballus	94.92	0.00e+00	651.00
IUUC-Fal-036965	Ficedula albicollis	90.27	0.00e+00	635.00
IUUC-Gmo-039523	Gadus morhua	73.02	3.00e-152	531.00
IUUC-Gga-040426	Gallus gallus	91.30	0.00e+00	644.00
IUUC-Gac-042642	Gasterosteus aculeatus	75.68	4.00e-159	553.00
IUUC-Ggo-045448	Gorilla gorilla	99.46	0.00e+00	717.00
IUUC-Itr-048752	Ictidomys tridecemlineatus	96.74	0.00e+00	701.00
IUUC-Lch-050334	Latimeria chalumnae	67.50	3.00e-132	464.00
IUUC-Loc-052447	Lepisosteus oculatus	78.28	8.00e-170	589.00
IUUC-Laf-053698	Loxodonta africana	96.47	0.00e+00	729.00
IUUC-Mcc-055547	Macaca mulatta	94.29	0.00e+00	646.00
IUUC-Meu-056398	Macropus eugenii	79.89	2.00e-170	591.00
IUUC-Mga-060168	Meleagris gallopavo	88.76	4.00e-175	607.00
IUUC-Mmr-061056	Microcebus murinus	97.28	0.00e+00	704.00
IUUC-Mmu-063596	Mus musculus	94.02	0.00e+00	679.00
IUUC-Mpu-066681	Mustela putorius furo	97.28	0.00e+00	704.00
IUUC-Mlu-068113	Myotis lucifugus	91.01	0.00e+00	654.00
IUUC-Nle-070104	Nomascus leucogenys	98.20	0.00e+00	637.00
IUUC-Opr-070661	Ochotona princeps	95.95	0.00e+00	691.00
IUUC-Ont-071922	Oreochromis niloticus	75.82	8.00e-159	553.00
IUUC-Ola-086645	Oryzias latipes	78.38	6.00e-174	603.00
IUUC-Oga-088627	Otolemur garnettii	96.89	0.00e+00	706.00
IUUC-Ptr-090929	Pan troglodytes	77.17	6.00e-146	509.00
IUUC-Pan-092433	Papio anubis	98.32	0.00e+00	672.00
IUUC-Psi-092940	Pelodiscus sinensis	89.42	0.00e+00	659.00
IUUC-Pma-094657	Petromyzon marinus	63.54	4.00e-122	431.00
IUUC-Pfo-096876	Poecilia formosa	76.09	5.00e-160	556.00
IUUC-Pab-097667	Pongo abelii	85.84	3.00e-162	563.00
IUUC-Pca-100102	Procavia capensis	89.40	0.00e+00	665.00
IUUC-Pva-102731	Pteropus vampyrus	86.96	6.00e-178	616.00
IUUC-Pgr-103312	Puccinia graminis	24.79	2.00e-15	77.40
IUUC-Ptt-103801	Puccinia triticina	22.78	5.00e-13	69.30
IUUC-Rno-105425	Rattus norvegicus	92.93	0.00e+00	683.00
IUUC-Sha-106675	Sarcophilus harrisii	92.29	0.00e+00	686.00
IUUC-Ssc-115548	Sus scrofa	96.21	0.00e+00	678.00
IUUC-Tru-117979	Takifugu rubripes	76.90	9.00e-162	562.00
IUUC-Tni-120585	Tetraodon nigroviridis	76.36	3.00e-161	560.00
IUUC-Ttr-128449	Tursiops truncatus	96.05	0.00e+00	647.00
IUUC-Xtr-131935	Xenopus tropicalis	82.34	9.00e-167	579.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence