iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Phospho.ELM	UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.30e-13	51.0	310	363

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
            +++lyd+e++nd+eL +++Gd +++   ++ de+W +g   l+g++G+fP  +v+ l
   Q: 310  SCKALYDFEPENDGELGFREGDLITLT--NQIDENWYEG--MLHGQSGFFPLSYVQVL 363
           69************************7..99********..8************9865 PP

Organism

Mus musculus

Functional Description
(View)

Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity).

Protein Sequence
(Fasta)

MSVAGLKKQF YKASQLVSEK VGGAEGTKLD DDFKDMEKKV DVTSKAVAEV LVRTIEYLQP 60
NPASRAKLTM LNTVSKIRGQ VKNPGYPQSE GLLGECMVRH GKELGGESNF GDALLDAGES 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTAATATCCC GGCCGCGCGT GCGCGCTAGC CGGCCGAGGT GGCTTCGGGG CGGGGGCGCA 60
GAGCTGGCAA GCTGATTTGG CGGTGGCGGC GCCGACCTGC GCGCGGAGGA AAGAAGTCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0965--Cell junction
KW-0966--Cell projection
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0254--Endocytosis
KW-0967--Endosome
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR027267--AH/BAR-dom
IPR004148--BAR_dom
IPR001452--SH3_domain

PROSITE

PS51021--BAR
PS50002--SH3

Pfam

PF03114--BAR
PF00018--SH3_1

PRINTS

PR00452--SH3DOMAIN

SMART

SM00721--BAR
SM00326--SH3

Gene Ontology

GO:0042995--C:cell projection
GO:0005913--C:cell-cell adherens junction
GO:0005737--C:cytoplasm
GO:0031901--C:early endosome membrane
GO:0002102--C:podosome
GO:0045202--C:synapse
GO:0098641--F:cadherin binding involved in cell-cell adhesion
GO:0042802--F:identical protein binding
GO:0008289--F:lipid binding
GO:0016191--P:synaptic vesicle uncoating

KEGG

mmu:20405

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001620	Ailuropoda melanoleuca	92.78	0.00e+00	652.00
IUUC-Apl-004209	Anas platyrhynchos	87.08	3.00e-172	597.00
IUUC-Ame-011047	Astyanax mexicanus	75.07	1.00e-155	542.00
IUUC-Bta-012875	Bos taurus	93.75	0.00e+00	711.00
IUUC-Cel-018509	Caenorhabditis elegans	44.59	3.00e-94	338.00
IUUC-Cin-025799	Ciona intestinalis	50.95	1.00e-103	369.00
IUUC-Csv-026266	Ciona savignyi	52.49	1.00e-101	362.00
IUUC-Cne-027089	Cryptococcus neoformans	25.74	8.00e-08	52.40
IUUC-Dre-027986	Danio rerio	73.19	7.00e-154	536.00
IUUC-Dno-029193	Dasypus novemcinctus	94.57	0.00e+00	687.00
IUUC-Dor-030288	Dipodomys ordii	85.33	2.00e-173	601.00
IUUC-Eca-033277	Equus caballus	94.07	0.00e+00	651.00
IUUC-Fal-036965	Ficedula albicollis	87.57	0.00e+00	628.00
IUUC-Gmo-039523	Gadus morhua	72.75	2.00e-151	528.00
IUUC-Gga-040426	Gallus gallus	88.04	0.00e+00	630.00
IUUC-Gac-042642	Gasterosteus aculeatus	75.41	3.00e-158	551.00
IUUC-Ggo-045448	Gorilla gorilla	94.02	0.00e+00	683.00
IUUC-Hsa-046112	Homo sapiens	94.02	0.00e+00	683.00
IUUC-Itr-048752	Ictidomys tridecemlineatus	95.65	0.00e+00	696.00
IUUC-Lch-050334	Latimeria chalumnae	69.01	1.00e-132	465.00
IUUC-Loc-052447	Lepisosteus oculatus	77.75	9.00e-169	585.00
IUUC-Laf-053698	Loxodonta africana	94.29	0.00e+00	717.00
IUUC-Mcc-055547	Macaca mulatta	88.86	2.00e-177	614.00
IUUC-Meu-056398	Macropus eugenii	78.26	2.00e-167	581.00
IUUC-Mga-060168	Meleagris gallopavo	85.39	5.00e-171	593.00
IUUC-Mmr-061056	Microcebus murinus	93.75	0.00e+00	682.00
IUUC-Mpu-066681	Mustela putorius furo	94.02	0.00e+00	684.00
IUUC-Mlu-068113	Myotis lucifugus	87.92	0.00e+00	634.00
IUUC-Nle-070104	Nomascus leucogenys	93.05	9.00e-175	605.00
IUUC-Opr-070661	Ochotona princeps	93.78	0.00e+00	680.00
IUUC-Ont-071922	Oreochromis niloticus	75.00	5.00e-157	546.00
IUUC-Ola-086645	Oryzias latipes	77.03	2.00e-170	591.00
IUUC-Oga-088627	Otolemur garnettii	92.94	0.00e+00	679.00
IUUC-Pan-092433	Papio anubis	92.74	0.00e+00	640.00
IUUC-Psi-092940	Pelodiscus sinensis	87.19	0.00e+00	649.00
IUUC-Pma-094657	Petromyzon marinus	63.26	2.00e-122	431.00
IUUC-Ppa-095161	Physcomitrella patens	25.67	1.00e-09	57.80
IUUC-Pfo-096876	Poecilia formosa	75.27	3.00e-157	547.00
IUUC-Pab-097667	Pongo abelii	81.02	3.00e-153	534.00
IUUC-Pca-100102	Procavia capensis	86.68	0.00e+00	648.00
IUUC-Pva-102731	Pteropus vampyrus	85.05	3.00e-175	607.00
IUUC-Pgr-103312	Puccinia graminis	24.37	9.00e-15	75.50
IUUC-Rno-105425	Rattus norvegicus	97.55	0.00e+00	709.00
IUUC-Sha-106675	Sarcophilus harrisii	90.36	0.00e+00	674.00
IUUC-Ssc-115548	Sus scrofa	93.50	0.00e+00	663.00
IUUC-Tru-117979	Takifugu rubripes	76.49	9.00e-161	559.00
IUUC-Tni-120585	Tetraodon nigroviridis	75.61	4.00e-159	553.00
IUUC-Ttr-128449	Tursiops truncatus	93.22	0.00e+00	633.00
IUUC-Xtr-131935	Xenopus tropicalis	80.43	7.00e-165	573.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence